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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Hck
Full Name:
Tyrosine-protein kinase HCK
Alias:
B-cell,myeloid kinase; B-cell/myeloid kinase; BMK; EC 2.7.10.2; Hemopoietic cell kinase; JTK9; Kinase Hck; P56-HCK and P60-HCK; P59-Hck; P59-HCK/p60-HCK; P60-Hck
Type:
EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family
Mass (Da):
59600
Number AA:
526
UniProt ID:
P08631
International Prot ID:
IPI00029769
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0007498
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Tyrosine-protein kinase Hck pan-specific antibody AB-NK271-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK271-1#Tyrosine-protein kinase Hck (C24-S43, human) peptide - Powder PE-01BDC80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDC80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T36
F
L
Q
V
G
G
N
T
F
S
K
T
E
T
S
Site 2
S38
Q
V
G
G
N
T
F
S
K
T
E
T
S
A
S
Site 3
T40
G
G
N
T
F
S
K
T
E
T
S
A
S
P
H
Site 4
T42
N
T
F
S
K
T
E
T
S
A
S
P
H
C
P
Site 5
S43
T
F
S
K
T
E
T
S
A
S
P
H
C
P
V
Site 6
S45
S
K
T
E
T
S
A
S
P
H
C
P
V
Y
V
Site 7
Y51
A
S
P
H
C
P
V
Y
V
P
D
P
T
S
T
Site 8
T56
P
V
Y
V
P
D
P
T
S
T
I
K
P
G
P
Site 9
S57
V
Y
V
P
D
P
T
S
T
I
K
P
G
P
N
Site 10
T58
Y
V
P
D
P
T
S
T
I
K
P
G
P
N
S
Site 11
S65
T
I
K
P
G
P
N
S
H
N
S
N
T
P
G
Site 12
S68
P
G
P
N
S
H
N
S
N
T
P
G
I
R
E
Site 13
T70
P
N
S
H
N
S
N
T
P
G
I
R
E
A
G
Site 14
Y87
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
Site 15
Y89
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
Site 16
S119
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Site 17
Y127
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
Site 18
S130
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
Site 19
Y132
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
Site 20
S138
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
Site 21
S167
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
Site 22
S173
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
Site 23
T175
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
Site 24
T176
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
Site 25
S179
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Site 26
Y180
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
Site 27
S181
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
Site 28
S183
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Site 29
Y187
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
Site 30
T194
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
Site 31
Y198
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
Site 32
T202
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
Site 33
Y209
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
Site 34
S211
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
Site 35
S214
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
Site 36
T215
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
Site 37
S217
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
Site 38
T218
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Site 39
Y226
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
Site 40
S238
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
Site 41
S243
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
Site 42
S244
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
Site 43
S261
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
Site 44
T280
F
G
E
V
W
M
A
T
Y
N
K
H
T
K
V
Site 45
Y281
G
E
V
W
M
A
T
Y
N
K
H
T
K
V
A
Site 46
T291
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
Site 47
T311
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
Site 48
Y330
V
V
T
K
E
P
I
Y
I
I
T
E
F
M
A
Site 49
S347
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
Site 50
S351
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
Site 51
Y377
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
Site 52
Y411
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
K
Site 53
T412
V
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
Site 54
S433
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
Site 55
Y458
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
Site 56
S462
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
Site 57
Y474
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
Site 58
Y487
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
Site 59
T503
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
Site 60
Y506
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
Site 61
Y515
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Site 62
T516
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Site 63
T518
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
Site 64
S520
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
_
Site 65
Y522
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation