KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CFH
Full Name:
Complement factor H
Alias:
Age-related maculopathy susceptibility 1; ARMS1; Beta-1H; Beta-1-H-globulin; CFAH; CFHL3; Complement factor H; Complement factor H, isoform b; Factor H; Factor H-like 1; FH; FHL1; H factor 1; H factor 2 (complement); HF; HF1; HF2; HUS
Type:
Secreted protein
Mass (Da):
139078
Number AA:
1231
UniProt ID:
P08603
International Prot ID:
IPI00029739
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006957
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
E
L
P
P
R
R
N
T
E
I
L
T
G
S
W
Site 2
T34
R
R
N
T
E
I
L
T
G
S
W
S
D
Q
T
Site 3
S36
N
T
E
I
L
T
G
S
W
S
D
Q
T
Y
P
Site 4
S38
E
I
L
T
G
S
W
S
D
Q
T
Y
P
E
G
Site 5
T41
T
G
S
W
S
D
Q
T
Y
P
E
G
T
Q
A
Site 6
Y42
G
S
W
S
D
Q
T
Y
P
E
G
T
Q
A
I
Site 7
Y50
P
E
G
T
Q
A
I
Y
K
C
R
P
G
Y
R
Site 8
Y56
I
Y
K
C
R
P
G
Y
R
S
L
G
N
V
I
Site 9
S58
K
C
R
P
G
Y
R
S
L
G
N
V
I
M
V
Site 10
T91
P
C
G
H
P
G
D
T
P
F
G
T
F
T
L
Site 11
T95
P
G
D
T
P
F
G
T
F
T
L
T
G
G
N
Site 12
Y112
E
Y
G
V
K
A
V
Y
T
C
N
E
G
Y
Q
Site 13
Y118
V
Y
T
C
N
E
G
Y
Q
L
L
G
E
I
N
Site 14
S159
P
E
N
G
K
I
V
S
S
A
M
E
P
D
R
Site 15
Y168
A
M
E
P
D
R
E
Y
H
F
G
Q
A
V
R
Site 16
S180
A
V
R
F
V
C
N
S
G
Y
K
I
E
G
D
Site 17
S219
S
P
D
V
I
N
G
S
P
I
S
Q
K
I
I
Site 18
S222
V
I
N
G
S
P
I
S
Q
K
I
I
Y
K
E
Site 19
Y227
P
I
S
Q
K
I
I
Y
K
E
N
E
R
F
Q
Site 20
Y235
K
E
N
E
R
F
Q
Y
K
C
N
M
G
Y
E
Site 21
Y241
Q
Y
K
C
N
M
G
Y
E
Y
S
E
R
G
D
Site 22
Y243
K
C
N
M
G
Y
E
Y
S
E
R
G
D
A
V
Site 23
S254
G
D
A
V
C
T
E
S
G
W
R
P
L
P
S
Site 24
S261
S
G
W
R
P
L
P
S
C
E
E
K
S
C
D
Site 25
S266
L
P
S
C
E
E
K
S
C
D
N
P
Y
I
P
Site 26
Y271
E
K
S
C
D
N
P
Y
I
P
N
G
D
Y
S
Site 27
Y277
P
Y
I
P
N
G
D
Y
S
P
L
R
I
K
H
Site 28
S278
Y
I
P
N
G
D
Y
S
P
L
R
I
K
H
R
Site 29
T286
P
L
R
I
K
H
R
T
G
D
E
I
T
Y
Q
Site 30
Y292
R
T
G
D
E
I
T
Y
Q
C
R
N
G
F
Y
Site 31
Y299
Y
Q
C
R
N
G
F
Y
P
A
T
R
G
N
T
Site 32
T306
Y
P
A
T
R
G
N
T
A
K
C
T
S
T
G
Site 33
Y327
C
T
L
K
P
C
D
Y
P
D
I
K
H
G
G
Site 34
Y336
D
I
K
H
G
G
L
Y
H
E
N
M
R
R
P
Site 35
Y344
H
E
N
M
R
R
P
Y
F
P
V
A
V
G
K
Site 36
Y355
A
V
G
K
Y
Y
S
Y
Y
C
D
E
H
F
E
Site 37
Y356
V
G
K
Y
Y
S
Y
Y
C
D
E
H
F
E
T
Site 38
T363
Y
C
D
E
H
F
E
T
P
S
G
S
Y
W
D
Site 39
Y390
V
P
C
L
R
K
C
Y
F
P
Y
L
E
N
G
Site 40
Y393
L
R
K
C
Y
F
P
Y
L
E
N
G
Y
N
Q
Site 41
Y398
F
P
Y
L
E
N
G
Y
N
Q
N
Y
G
R
K
Site 42
Y402
E
N
G
Y
N
Q
N
Y
G
R
K
F
V
Q
G
Site 43
S411
R
K
F
V
Q
G
K
S
I
D
V
A
C
H
P
Site 44
Y420
D
V
A
C
H
P
G
Y
A
L
P
K
A
Q
T
Site 45
T439
M
E
N
G
W
S
P
T
P
R
C
I
R
V
K
Site 46
T447
P
R
C
I
R
V
K
T
C
S
K
S
S
I
D
Site 47
S449
C
I
R
V
K
T
C
S
K
S
S
I
D
I
E
Site 48
S451
R
V
K
T
C
S
K
S
S
I
D
I
E
N
G
Site 49
S461
D
I
E
N
G
F
I
S
E
S
Q
Y
T
Y
A
Site 50
S463
E
N
G
F
I
S
E
S
Q
Y
T
Y
A
L
K
Site 51
Y465
G
F
I
S
E
S
Q
Y
T
Y
A
L
K
E
K
Site 52
T466
F
I
S
E
S
Q
Y
T
Y
A
L
K
E
K
A
Site 53
Y467
I
S
E
S
Q
Y
T
Y
A
L
K
E
K
A
K
Site 54
Y475
A
L
K
E
K
A
K
Y
Q
C
K
L
G
Y
V
Site 55
Y481
K
Y
Q
C
K
L
G
Y
V
T
A
D
G
E
T
Site 56
S491
A
D
G
E
T
S
G
S
I
T
C
G
K
D
G
Site 57
T493
G
E
T
S
G
S
I
T
C
G
K
D
G
W
S
Site 58
T524
A
R
T
K
N
D
F
T
W
F
K
L
N
D
T
Site 59
Y534
K
L
N
D
T
L
D
Y
E
C
H
D
G
Y
E
Site 60
Y540
D
Y
E
C
H
D
G
Y
E
S
N
T
G
S
T
Site 61
S542
E
C
H
D
G
Y
E
S
N
T
G
S
T
T
G
Site 62
S546
G
Y
E
S
N
T
G
S
T
T
G
S
I
V
C
Site 63
S550
N
T
G
S
T
T
G
S
I
V
C
G
Y
N
G
Site 64
Y555
T
G
S
I
V
C
G
Y
N
G
W
S
D
L
P
Site 65
Y565
W
S
D
L
P
I
C
Y
E
R
E
C
E
L
P
Site 66
Y587
P
D
R
K
K
D
Q
Y
K
V
G
E
V
L
K
Site 67
Y612
G
P
N
S
V
Q
C
Y
H
F
G
L
S
P
D
Site 68
S629
I
C
K
E
Q
V
Q
S
C
G
P
P
P
E
L
Site 69
T645
N
G
N
V
K
E
K
T
K
E
E
Y
G
H
S
Site 70
Y657
G
H
S
E
V
V
E
Y
Y
C
N
P
R
F
L
Site 71
Y658
H
S
E
V
V
E
Y
Y
C
N
P
R
F
L
M
Site 72
S706
H
G
W
A
Q
L
S
S
P
P
Y
Y
Y
G
D
Site 73
Y709
A
Q
L
S
S
P
P
Y
Y
Y
G
D
S
V
E
Site 74
Y710
Q
L
S
S
P
P
Y
Y
Y
G
D
S
V
E
F
Site 75
Y711
L
S
S
P
P
Y
Y
Y
G
D
S
V
E
F
N
Site 76
S720
D
S
V
E
F
N
C
S
E
S
F
T
M
I
G
Site 77
S755
D
K
L
K
K
C
K
S
S
N
L
I
I
L
E
Site 78
Y779
D
H
N
S
N
I
R
Y
R
C
R
G
K
E
G
Site 79
S820
P
P
P
Q
I
P
N
S
H
N
M
T
T
T
L
Site 80
Y843
S
V
L
C
Q
E
N
Y
L
I
Q
E
G
E
E
Site 81
T880
P
P
Q
I
E
H
G
T
I
N
S
S
R
S
S
Site 82
S883
I
E
H
G
T
I
N
S
S
R
S
S
Q
E
S
Site 83
S884
E
H
G
T
I
N
S
S
R
S
S
Q
E
S
Y
Site 84
S886
G
T
I
N
S
S
R
S
S
Q
E
S
Y
A
H
Site 85
S887
T
I
N
S
S
R
S
S
Q
E
S
Y
A
H
G
Site 86
S890
S
S
R
S
S
Q
E
S
Y
A
H
G
T
K
L
Site 87
Y899
A
H
G
T
K
L
S
Y
T
C
E
G
G
F
R
Site 88
T900
H
G
T
K
L
S
Y
T
C
E
G
G
F
R
I
Site 89
S908
C
E
G
G
F
R
I
S
E
E
N
E
T
T
C
Site 90
Y916
E
E
N
E
T
T
C
Y
M
G
K
W
S
S
P
Site 91
S933
C
E
G
L
P
C
K
S
P
P
E
I
S
H
G
Site 92
S948
V
V
A
H
M
S
D
S
Y
Q
Y
G
E
E
V
Site 93
Y949
V
A
H
M
S
D
S
Y
Q
Y
G
E
E
V
T
Site 94
Y957
Q
Y
G
E
E
V
T
Y
K
C
F
E
G
F
G
Site 95
T987
H
P
P
S
C
I
K
T
D
C
L
S
L
P
S
Site 96
Y1008
M
G
E
K
K
D
V
Y
K
A
G
E
Q
V
T
Site 97
Y1016
K
A
G
E
Q
V
T
Y
T
C
A
T
Y
Y
K
Site 98
T1017
A
G
E
Q
V
T
Y
T
C
A
T
Y
Y
K
M
Site 99
Y1021
V
T
Y
T
C
A
T
Y
Y
K
M
D
G
A
S
Site 100
Y1022
T
Y
T
C
A
T
Y
Y
K
M
D
G
A
S
N
Site 101
T1042
S
R
W
T
G
R
P
T
C
R
D
T
S
C
V
Site 102
T1046
G
R
P
T
C
R
D
T
S
C
V
N
P
P
T
Site 103
S1047
R
P
T
C
R
D
T
S
C
V
N
P
P
T
V
Site 104
Y1058
P
P
T
V
Q
N
A
Y
I
V
S
R
Q
M
S
Site 105
S1065
Y
I
V
S
R
Q
M
S
K
Y
P
S
G
E
R
Site 106
Y1067
V
S
R
Q
M
S
K
Y
P
S
G
E
R
V
R
Site 107
S1069
R
Q
M
S
K
Y
P
S
G
E
R
V
R
Y
Q
Site 108
Y1075
P
S
G
E
R
V
R
Y
Q
C
R
S
P
Y
E
Site 109
S1079
R
V
R
Y
Q
C
R
S
P
Y
E
M
F
G
D
Site 110
Y1081
R
Y
Q
C
R
S
P
Y
E
M
F
G
D
E
E
Site 111
S1105
E
P
P
Q
C
K
D
S
T
G
K
C
G
P
P
Site 112
T1106
P
P
Q
C
K
D
S
T
G
K
C
G
P
P
P
Site 113
T1121
P
I
D
N
G
D
I
T
S
F
P
L
S
V
Y
Site 114
S1132
L
S
V
Y
A
P
A
S
S
V
E
Y
Q
C
Q
Site 115
S1133
S
V
Y
A
P
A
S
S
V
E
Y
Q
C
Q
N
Site 116
Y1136
A
P
A
S
S
V
E
Y
Q
C
Q
N
L
Y
Q
Site 117
Y1142
E
Y
Q
C
Q
N
L
Y
Q
L
E
G
N
K
R
Site 118
T1184
Y
N
I
A
L
R
W
T
A
K
Q
K
L
Y
S
Site 119
Y1190
W
T
A
K
Q
K
L
Y
S
R
T
G
E
S
V
Site 120
S1191
T
A
K
Q
K
L
Y
S
R
T
G
E
S
V
E
Site 121
T1193
K
Q
K
L
Y
S
R
T
G
E
S
V
E
F
V
Site 122
Y1205
E
F
V
C
K
R
G
Y
R
L
S
S
R
S
H
Site 123
S1208
C
K
R
G
Y
R
L
S
S
R
S
H
T
L
R
Site 124
S1209
K
R
G
Y
R
L
S
S
R
S
H
T
L
R
T
Site 125
S1211
G
Y
R
L
S
S
R
S
H
T
L
R
T
T
C
Site 126
T1213
R
L
S
S
R
S
H
T
L
R
T
T
C
W
D
Site 127
T1216
S
R
S
H
T
L
R
T
T
C
W
D
G
K
L
Site 128
T1217
R
S
H
T
L
R
T
T
C
W
D
G
K
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation