KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LPA
Full Name:
Apolipoprotein(a)
Alias:
Type:
Mass (Da):
501319
Number AA:
4548
UniProt ID:
P08519
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
S
H
V
V
Q
D
C
Y
H
G
D
G
Q
S
Y
Site 2
T39
D
G
Q
S
Y
R
G
T
Y
S
T
T
V
T
G
Site 3
Y40
G
Q
S
Y
R
G
T
Y
S
T
T
V
T
G
R
Site 4
S41
Q
S
Y
R
G
T
Y
S
T
T
V
T
G
R
T
Site 5
T42
S
Y
R
G
T
Y
S
T
T
V
T
G
R
T
C
Site 6
T43
Y
R
G
T
Y
S
T
T
V
T
G
R
T
C
Q
Site 7
T45
G
T
Y
S
T
T
V
T
G
R
T
C
Q
A
W
Site 8
T64
P
H
Q
H
N
R
T
T
E
N
Y
P
N
A
G
Site 9
Y67
H
N
R
T
T
E
N
Y
P
N
A
G
L
I
M
Site 10
Y76
N
A
G
L
I
M
N
Y
C
R
N
P
D
A
V
Site 11
Y89
A
V
A
A
P
Y
C
Y
T
R
D
P
G
V
R
Site 12
Y99
D
P
G
V
R
W
E
Y
C
N
L
T
Q
C
S
Site 13
T133
A
P
S
E
Q
A
P
T
E
Q
R
P
G
V
Q
Site 14
Y143
R
P
G
V
Q
E
C
Y
H
G
N
G
Q
S
Y
Site 15
T153
N
G
Q
S
Y
R
G
T
Y
S
T
T
V
T
G
Site 16
T170
C
Q
A
W
S
S
M
T
P
H
S
H
S
R
T
Site 17
S173
W
S
S
M
T
P
H
S
H
S
R
T
P
E
Y
Site 18
S175
S
M
T
P
H
S
H
S
R
T
P
E
Y
Y
P
Site 19
T177
T
P
H
S
H
S
R
T
P
E
Y
Y
P
N
A
Site 20
Y180
S
H
S
R
T
P
E
Y
Y
P
N
A
G
L
I
Site 21
Y181
H
S
R
T
P
E
Y
Y
P
N
A
G
L
I
M
Site 22
Y3382
N
A
G
L
I
M
N
Y
C
R
N
P
D
P
V
Site 23
Y3395
P
V
A
A
P
Y
C
Y
T
R
D
P
S
V
R
Site 24
Y3405
D
P
S
V
R
W
E
Y
C
N
L
T
Q
C
S
Site 25
S3429
P
T
I
T
P
I
P
S
L
E
A
P
S
E
Q
Site 26
T3459
N
G
Q
S
Y
Q
G
T
Y
F
I
T
V
T
G
Site 27
Y3460
G
Q
S
Y
Q
G
T
Y
F
I
T
V
T
G
R
Site 28
S3479
W
S
S
M
T
P
H
S
H
S
R
T
P
A
Y
Site 29
S3481
S
M
T
P
H
S
H
S
R
T
P
A
Y
Y
P
Site 30
T3483
T
P
H
S
H
S
R
T
P
A
Y
Y
P
N
A
Site 31
Y3486
S
H
S
R
T
P
A
Y
Y
P
N
A
G
L
I
Site 32
Y3487
H
S
R
T
P
A
Y
Y
P
N
A
G
L
I
K
Site 33
Y3496
N
A
G
L
I
K
N
Y
C
R
N
P
D
P
V
Site 34
Y3519
D
P
S
V
R
W
E
Y
C
N
L
T
R
C
S
Site 35
T3553
A
F
F
E
Q
A
L
T
E
E
T
P
G
V
Q
Site 36
T3556
E
Q
A
L
T
E
E
T
P
G
V
Q
D
C
Y
Site 37
Y3563
T
P
G
V
Q
D
C
Y
Y
H
Y
G
Q
S
Y
Site 38
Y3564
P
G
V
Q
D
C
Y
Y
H
Y
G
Q
S
Y
R
Site 39
T3573
Y
G
Q
S
Y
R
G
T
Y
S
T
T
V
T
G
Site 40
S3595
S
M
T
P
H
Q
H
S
R
T
P
E
N
Y
P
Site 41
T3597
T
P
H
Q
H
S
R
T
P
E
N
Y
P
N
A
Site 42
Y3601
H
S
R
T
P
E
N
Y
P
N
A
G
L
T
R
Site 43
Y3610
N
A
G
L
T
R
N
Y
C
R
N
P
D
A
E
Site 44
Y3633
D
P
S
V
R
W
E
Y
C
N
L
T
Q
C
L
Site 45
S3657
L
T
V
V
P
D
P
S
T
E
A
S
S
E
E
Site 46
T3658
T
V
V
P
D
P
S
T
E
A
S
S
E
E
A
Site 47
S3661
P
D
P
S
T
E
A
S
S
E
E
A
P
T
E
Site 48
T3667
A
S
S
E
E
A
P
T
E
Q
S
P
G
V
Q
Site 49
S3670
E
E
A
P
T
E
Q
S
P
G
V
Q
D
C
Y
Site 50
Y3677
S
P
G
V
Q
D
C
Y
H
G
D
G
Q
S
Y
Site 51
S3683
C
Y
H
G
D
G
Q
S
Y
R
G
S
F
S
T
Site 52
S3687
D
G
Q
S
Y
R
G
S
F
S
T
T
V
T
G
Site 53
T3690
S
Y
R
G
S
F
S
T
T
V
T
G
R
T
C
Site 54
T3691
Y
R
G
S
F
S
T
T
V
T
G
R
T
C
Q
Site 55
T3693
G
S
F
S
T
T
V
T
G
R
T
C
Q
S
W
Site 56
Y3714
W
H
Q
R
T
T
E
Y
Y
P
N
G
G
L
T
Site 57
Y3715
H
Q
R
T
T
E
Y
Y
P
N
G
G
L
T
R
Site 58
Y3724
N
G
G
L
T
R
N
Y
C
R
N
P
D
A
E
Site 59
T3763
T
E
S
S
V
L
A
T
S
T
A
V
S
E
Q
Site 60
S3764
E
S
S
V
L
A
T
S
T
A
V
S
E
Q
A
Site 61
S3768
L
A
T
S
T
A
V
S
E
Q
A
P
T
E
Q
Site 62
T3773
A
V
S
E
Q
A
P
T
E
Q
S
P
T
V
Q
Site 63
S3776
E
Q
A
P
T
E
Q
S
P
T
V
Q
D
C
Y
Site 64
T3778
A
P
T
E
Q
S
P
T
V
Q
D
C
Y
H
G
Site 65
Y3783
S
P
T
V
Q
D
C
Y
H
G
D
G
Q
S
Y
Site 66
Y3853
D
P
S
V
R
W
E
Y
C
N
L
T
Q
C
P
Site 67
T3878
T
V
V
P
V
P
S
T
E
L
P
S
E
E
A
Site 68
T3887
L
P
S
E
E
A
P
T
E
N
S
T
G
V
Q
Site 69
S3890
E
E
A
P
T
E
N
S
T
G
V
Q
D
C
Y
Site 70
Y3897
S
T
G
V
Q
D
C
Y
R
G
D
G
Q
S
Y
Site 71
S3903
C
Y
R
G
D
G
Q
S
Y
R
G
T
L
S
T
Site 72
T3907
D
G
Q
S
Y
R
G
T
L
S
T
T
I
T
G
Site 73
S3909
Q
S
Y
R
G
T
L
S
T
T
I
T
G
R
T
Site 74
T3910
S
Y
R
G
T
L
S
T
T
I
T
G
R
T
C
Site 75
T3913
G
T
L
S
T
T
I
T
G
R
T
C
Q
S
W
Site 76
Y3934
W
H
R
R
I
P
L
Y
Y
P
N
A
G
L
T
Site 77
Y3935
H
R
R
I
P
L
Y
Y
P
N
A
G
L
T
R
Site 78
Y3967
D
P
S
V
R
W
E
Y
C
N
L
T
R
C
P
Site 79
T3976
N
L
T
R
C
P
V
T
E
S
S
V
L
T
T
Site 80
S3991
P
T
V
A
P
V
P
S
T
E
A
P
S
E
Q
Site 81
T3992
T
V
A
P
V
P
S
T
E
A
P
S
E
Q
A
Site 82
S4004
E
Q
A
P
P
E
K
S
P
V
V
Q
D
C
Y
Site 83
Y4011
S
P
V
V
Q
D
C
Y
H
G
D
G
R
S
Y
Site 84
S4017
C
Y
H
G
D
G
R
S
Y
R
G
I
S
S
T
Site 85
Y4018
Y
H
G
D
G
R
S
Y
R
G
I
S
S
T
T
Site 86
S4022
G
R
S
Y
R
G
I
S
S
T
T
V
T
G
R
Site 87
T4024
S
Y
R
G
I
S
S
T
T
V
T
G
R
T
C
Site 88
T4025
Y
R
G
I
S
S
T
T
V
T
G
R
T
C
Q
Site 89
T4027
G
I
S
S
T
T
V
T
G
R
T
C
Q
S
W
Site 90
T4045
I
P
H
W
H
Q
R
T
P
E
N
Y
P
N
A
Site 91
Y4049
H
Q
R
T
P
E
N
Y
P
N
A
G
L
T
E
Site 92
Y4058
N
A
G
L
T
E
N
Y
C
R
N
P
D
S
G
Site 93
S4088
Y
C
N
L
T
Q
C
S
E
T
E
S
G
V
L
Site 94
S4092
T
Q
C
S
E
T
E
S
G
V
L
E
T
P
T
Site 95
S4105
P
T
V
V
P
V
P
S
M
E
A
H
S
E
A
Site 96
T4115
A
H
S
E
A
A
P
T
E
Q
T
P
V
V
R
Site 97
T4118
E
A
A
P
T
E
Q
T
P
V
V
R
Q
C
Y
Site 98
Y4125
T
P
V
V
R
Q
C
Y
H
G
N
G
Q
S
Y
Site 99
T4135
N
G
Q
S
Y
R
G
T
F
S
T
T
V
T
G
Site 100
S4137
Q
S
Y
R
G
T
F
S
T
T
V
T
G
R
T
Site 101
T4138
S
Y
R
G
T
F
S
T
T
V
T
G
R
T
C
Site 102
T4139
Y
R
G
T
F
S
T
T
V
T
G
R
T
C
Q
Site 103
T4141
G
T
F
S
T
T
V
T
G
R
T
C
Q
S
W
Site 104
T4152
C
Q
S
W
S
S
M
T
P
H
R
H
Q
R
T
Site 105
T4159
T
P
H
R
H
Q
R
T
P
E
N
Y
P
N
D
Site 106
Y4163
H
Q
R
T
P
E
N
Y
P
N
D
G
L
T
M
Site 107
Y4172
N
D
G
L
T
M
N
Y
C
R
N
P
D
A
D
Site 108
Y4195
D
P
S
I
R
W
E
Y
C
N
L
T
R
C
S
Site 109
S4202
Y
C
N
L
T
R
C
S
D
T
E
G
T
V
V
Site 110
T4207
R
C
S
D
T
E
G
T
V
V
A
P
P
T
V
Site 111
S4219
P
T
V
I
Q
V
P
S
L
G
P
P
S
E
Q
Site 112
S4224
V
P
S
L
G
P
P
S
E
Q
D
C
M
F
G
Site 113
T4242
G
Y
R
G
K
K
A
T
T
V
T
G
T
P
C
Site 114
T4243
Y
R
G
K
K
A
T
T
V
T
G
T
P
C
Q
Site 115
T4245
G
K
K
A
T
T
V
T
G
T
P
C
Q
E
W
Site 116
T4247
K
A
T
T
V
T
G
T
P
C
Q
E
W
A
A
Site 117
S4261
A
Q
E
P
H
R
H
S
T
F
I
P
G
T
N
Site 118
T4262
Q
E
P
H
R
H
S
T
F
I
P
G
T
N
K
Site 119
Y4277
W
A
G
L
E
K
N
Y
C
R
N
P
D
G
D
Site 120
Y4301
N
P
R
K
L
F
D
Y
C
D
I
P
L
C
A
Site 121
S4311
I
P
L
C
A
S
S
S
F
D
C
G
K
P
Q
Site 122
T4366
I
S
P
E
W
V
L
T
A
A
H
C
L
K
K
Site 123
S4374
A
A
H
C
L
K
K
S
S
R
P
S
S
Y
K
Site 124
S4375
A
H
C
L
K
K
S
S
R
P
S
S
Y
K
V
Site 125
S4378
L
K
K
S
S
R
P
S
S
Y
K
V
I
L
G
Site 126
S4379
K
K
S
S
R
P
S
S
Y
K
V
I
L
G
A
Site 127
Y4380
K
S
S
R
P
S
S
Y
K
V
I
L
G
A
H
Site 128
S4402
H
V
Q
E
I
E
V
S
R
L
F
L
E
P
T
Site 129
Y4438
A
C
L
P
S
P
D
Y
M
V
T
A
R
T
E
Site 130
T4441
P
S
P
D
Y
M
V
T
A
R
T
E
C
Y
I
Site 131
Y4447
V
T
A
R
T
E
C
Y
I
T
G
W
G
E
T
Site 132
T4449
A
R
T
E
C
Y
I
T
G
W
G
E
T
Q
G
Site 133
T4457
G
W
G
E
T
Q
G
T
F
G
T
G
L
L
K
Site 134
T4491
A
E
H
L
A
R
G
T
D
S
C
Q
G
D
S
Site 135
S4493
H
L
A
R
G
T
D
S
C
Q
G
D
S
G
G
Site 136
Y4510
V
C
F
E
K
D
K
Y
I
L
Q
G
V
T
S
Site 137
Y4531
R
P
N
K
P
G
V
Y
A
R
V
S
R
F
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation