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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP2
Full Name:
72 kDa type IV collagenase
Alias:
72 kDa gelatinase; 72 kDa type IV collagenase; CLG4; CLG4A; Collagenase type IV-A; EC 3.4.24.24; Gelatinase A; Gelatinase A gelatinase type IV collagenase; Gelatinase A MMP-2; Matrix metallopeptidase 2; MMP-2; MMP-II; MONA; TBE-1
Type:
Protease; EC 3.4.24.24
Mass (Da):
73882
Number AA:
660
UniProt ID:
P08253
International Prot ID:
IPI00027780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0043231
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030574
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Matrix metalloproteinase-2 (Y110-R115, human) peptide - Powder PE-01ACF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACF95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
L
M
A
R
G
A
L
T
G
P
L
R
A
L
C
Site 2
T45
P
G
D
V
A
P
K
T
D
K
E
L
A
V
Q
Site 3
Y53
D
K
E
L
A
V
Q
Y
L
N
T
F
Y
G
C
Site 4
T56
L
A
V
Q
Y
L
N
T
F
Y
G
C
P
K
E
Site 5
Y58
V
Q
Y
L
N
T
F
Y
G
C
P
K
E
S
C
Site 6
T93
T
G
D
L
D
Q
N
T
I
E
T
M
R
K
P
Site 7
T96
L
D
Q
N
T
I
E
T
M
R
K
P
R
C
G
Site 8
T132
T
Y
R
I
I
G
Y
T
P
D
L
D
P
E
T
Site 9
T139
T
P
D
L
D
P
E
T
V
D
D
A
F
A
R
Site 10
T155
F
Q
V
W
S
D
V
T
P
L
R
F
S
R
I
Site 11
S160
D
V
T
P
L
R
F
S
R
I
H
D
G
E
A
Site 12
Y182
R
W
E
H
G
D
G
Y
P
F
D
G
K
D
G
Site 13
T199
A
H
A
F
A
P
G
T
G
V
G
G
D
S
H
Site 14
Y225
G
Q
V
V
R
V
K
Y
G
N
A
D
G
E
Y
Site 15
Y232
Y
G
N
A
D
G
E
Y
C
K
F
P
F
L
F
Site 16
S246
F
N
G
K
E
Y
N
S
C
T
D
T
G
R
S
Site 17
T248
G
K
E
Y
N
S
C
T
D
T
G
R
S
D
G
Site 18
T250
E
Y
N
S
C
T
D
T
G
R
S
D
G
F
L
Site 19
Y271
N
F
E
K
D
G
K
Y
G
F
C
P
H
E
A
Site 20
T281
C
P
H
E
A
L
F
T
M
G
G
N
A
E
G
Site 21
S301
P
F
R
F
Q
G
T
S
Y
D
S
C
T
T
E
Site 22
Y302
F
R
F
Q
G
T
S
Y
D
S
C
T
T
E
G
Site 23
T306
G
T
S
Y
D
S
C
T
T
E
G
R
T
D
G
Site 24
Y314
T
E
G
R
T
D
G
Y
R
W
C
G
T
T
E
Site 25
Y323
W
C
G
T
T
E
D
Y
D
R
D
K
K
Y
G
Site 26
Y329
D
Y
D
R
D
K
K
Y
G
F
C
P
E
T
A
Site 27
T335
K
Y
G
F
C
P
E
T
A
M
S
T
V
G
G
Site 28
S338
F
C
P
E
T
A
M
S
T
V
G
G
N
S
E
Site 29
T339
C
P
E
T
A
M
S
T
V
G
G
N
S
E
G
Site 30
Y360
F
T
F
L
G
N
K
Y
E
S
C
T
S
A
G
Site 31
S362
F
L
G
N
K
Y
E
S
C
T
S
A
G
R
S
Site 32
T364
G
N
K
Y
E
S
C
T
S
A
G
R
S
D
G
Site 33
S365
N
K
Y
E
S
C
T
S
A
G
R
S
D
G
K
Site 34
S369
S
C
T
S
A
G
R
S
D
G
K
M
W
C
A
Site 35
T377
D
G
K
M
W
C
A
T
T
A
N
Y
D
D
D
Site 36
T378
G
K
M
W
C
A
T
T
A
N
Y
D
D
D
R
Site 37
S414
H
A
M
G
L
E
H
S
Q
D
P
G
A
L
M
Site 38
Y425
G
A
L
M
A
P
I
Y
T
Y
T
K
N
F
R
Site 39
S434
Y
T
K
N
F
R
L
S
Q
D
D
I
K
G
I
Site 40
Y445
I
K
G
I
Q
E
L
Y
G
A
S
P
D
I
D
Site 41
S448
I
Q
E
L
Y
G
A
S
P
D
I
D
L
G
T
Site 42
T455
S
P
D
I
D
L
G
T
G
P
T
P
T
L
G
Site 43
T460
L
G
T
G
P
T
P
T
L
G
P
V
T
P
E
Site 44
T465
T
P
T
L
G
P
V
T
P
E
I
C
K
Q
D
Site 45
T496
K
D
R
F
I
W
R
T
V
T
P
R
D
K
P
Site 46
T498
R
F
I
W
R
T
V
T
P
R
D
K
P
M
G
Site 47
Y524
P
E
K
I
D
A
V
Y
E
A
P
Q
E
E
K
Site 48
Y543
A
G
N
E
Y
W
I
Y
S
A
S
T
L
E
R
Site 49
S544
G
N
E
Y
W
I
Y
S
A
S
T
L
E
R
G
Site 50
S546
E
Y
W
I
Y
S
A
S
T
L
E
R
G
Y
P
Site 51
Y552
A
S
T
L
E
R
G
Y
P
K
P
L
T
S
L
Site 52
T557
R
G
Y
P
K
P
L
T
S
L
G
L
P
P
D
Site 53
S558
G
Y
P
K
P
L
T
S
L
G
L
P
P
D
V
Site 54
Y591
A
G
D
K
F
W
R
Y
N
E
V
K
K
K
M
Site 55
Y630
L
Q
G
G
G
H
S
Y
F
F
K
G
A
Y
Y
Site 56
Y636
S
Y
F
F
K
G
A
Y
Y
L
K
L
E
N
Q
Site 57
Y637
Y
F
F
K
G
A
Y
Y
L
K
L
E
N
Q
S
Site 58
S644
Y
L
K
L
E
N
Q
S
L
K
S
V
K
F
G
Site 59
S647
L
E
N
Q
S
L
K
S
V
K
F
G
S
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation