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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHRM4
Full Name:
Muscarinic acetylcholine receptor M4
Alias:
ACM4; Cholinergic receptor, muscarinic 4; HM4
Type:
Receptor - G protein-coupled; plasma membrane, integral plasma membrane, postsynaptic membrane, synapse, basolateral plasma membrane, cell junction protein
Mass (Da):
53049
Number AA:
479
UniProt ID:
P08173
International Prot ID:
IPI00027474
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005887
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0004981
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007213
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
N
G
S
S
G
N
Q
S
V
R
L
V
T
S
S
Site 2
T20
N
Q
S
V
R
L
V
T
S
S
S
H
N
R
Y
Site 3
S22
S
V
R
L
V
T
S
S
S
H
N
R
Y
E
T
Site 4
S23
V
R
L
V
T
S
S
S
H
N
R
Y
E
T
V
Site 5
Y27
T
S
S
S
H
N
R
Y
E
T
V
E
M
V
F
Site 6
T29
S
S
H
N
R
Y
E
T
V
E
M
V
F
I
A
Site 7
T65
K
V
N
R
Q
L
Q
T
V
N
N
Y
F
L
F
Site 8
T135
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
A
Site 9
T139
F
C
V
T
K
P
L
T
Y
P
A
R
R
T
T
Site 10
Y140
C
V
T
K
P
L
T
Y
P
A
R
R
T
T
K
Site 11
T145
L
T
Y
P
A
R
R
T
T
K
M
A
G
L
M
Site 12
T146
T
Y
P
A
R
R
T
T
K
M
A
G
L
M
I
Site 13
T179
Q
F
V
V
G
K
R
T
V
P
D
N
Q
C
F
Site 14
S224
H
I
S
L
A
S
R
S
R
V
H
K
H
R
P
Site 15
T241
P
K
E
K
K
A
K
T
L
A
F
L
K
S
P
Site 16
S247
K
T
L
A
F
L
K
S
P
L
M
K
Q
S
V
Site 17
S253
K
S
P
L
M
K
Q
S
V
K
K
P
P
P
G
Site 18
T292
R
P
V
A
D
K
D
T
S
N
E
S
S
S
G
Site 19
S293
P
V
A
D
K
D
T
S
N
E
S
S
S
G
S
Site 20
S296
D
K
D
T
S
N
E
S
S
S
G
S
A
T
Q
Site 21
S297
K
D
T
S
N
E
S
S
S
G
S
A
T
Q
N
Site 22
S298
D
T
S
N
E
S
S
S
G
S
A
T
Q
N
T
Site 23
S300
S
N
E
S
S
S
G
S
A
T
Q
N
T
K
E
Site 24
T302
E
S
S
S
G
S
A
T
Q
N
T
K
E
R
P
Site 25
T311
N
T
K
E
R
P
A
T
E
L
S
T
T
E
A
Site 26
S314
E
R
P
A
T
E
L
S
T
T
E
A
T
T
P
Site 27
T316
P
A
T
E
L
S
T
T
E
A
T
T
P
A
M
Site 28
T320
L
S
T
T
E
A
T
T
P
A
M
P
A
P
P
Site 29
S337
P
R
A
L
N
P
A
S
R
W
S
K
I
Q
I
Site 30
S340
L
N
P
A
S
R
W
S
K
I
Q
I
V
T
K
Site 31
S379
N
V
A
R
K
F
A
S
I
A
R
N
Q
V
R
Site 32
T463
C
N
A
T
F
K
K
T
F
R
H
L
L
L
C
Site 33
Y472
R
H
L
L
L
C
Q
Y
R
N
I
G
T
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation