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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FH
Full Name:
Fumarate hydratase, mitochondrial
Alias:
EC 4.2.1.2; Fumarase; FUMH
Type:
Enzyme, lyase, tumour suppressor
Mass (Da):
54637
Number AA:
510
UniProt ID:
P07954
International Prot ID:
IPI00296053
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0045239
Uniprot
OncoNet
Molecular Function:
GO:0004333
PhosphoSite+
KinaseNET
Biological Process:
GO:0006106
GO:0006099
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
P
N
A
A
R
M
A
S
Q
N
S
F
R
I
E
Site 2
S49
A
R
M
A
S
Q
N
S
F
R
I
E
Y
D
T
Site 3
Y54
Q
N
S
F
R
I
E
Y
D
T
F
G
E
L
K
Site 4
T56
S
F
R
I
E
Y
D
T
F
G
E
L
K
V
P
Site 5
Y67
L
K
V
P
N
D
K
Y
Y
G
A
Q
T
V
R
Site 6
Y68
K
V
P
N
D
K
Y
Y
G
A
Q
T
V
R
S
Site 7
T72
D
K
Y
Y
G
A
Q
T
V
R
S
T
M
N
F
Site 8
T76
G
A
Q
T
V
R
S
T
M
N
F
K
I
G
G
Site 9
T85
N
F
K
I
G
G
V
T
E
R
M
P
T
P
V
Site 10
T90
G
V
T
E
R
M
P
T
P
V
I
K
A
F
G
Site 11
Y110
A
A
E
V
N
Q
D
Y
G
L
D
P
K
I
A
Site 12
T149
Q
T
G
S
G
T
Q
T
N
M
N
V
N
E
V
Site 13
S184
P
N
D
H
V
N
K
S
Q
S
S
N
D
T
F
Site 14
S186
D
H
V
N
K
S
Q
S
S
N
D
T
F
P
T
Site 15
T190
K
S
Q
S
S
N
D
T
F
P
T
A
M
H
I
Site 16
S222
H
D
A
L
D
A
K
S
K
E
F
A
Q
I
I
Site 17
T236
I
K
I
G
R
T
H
T
Q
D
A
V
P
L
T
Site 18
T243
T
Q
D
A
V
P
L
T
L
G
Q
E
F
S
G
Site 19
S249
L
T
L
G
Q
E
F
S
G
Y
V
Q
Q
V
K
Site 20
Y251
L
G
Q
E
F
S
G
Y
V
Q
Q
V
K
Y
A
Site 21
Y257
G
Y
V
Q
Q
V
K
Y
A
M
T
R
I
K
A
Site 22
Y270
K
A
A
M
P
R
I
Y
E
L
A
A
G
G
T
Site 23
T285
A
V
G
T
G
L
N
T
R
I
G
F
A
E
K
Site 24
S347
N
D
I
R
F
L
G
S
G
P
R
S
G
L
G
Site 25
S365
L
P
E
N
E
P
G
S
S
I
M
P
G
K
V
Site 26
S366
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
Site 27
T395
M
G
N
H
V
A
V
T
V
G
G
S
N
G
H
Site 28
Y465
A
L
N
P
H
I
G
Y
D
K
A
A
K
I
A
Site 29
T474
K
A
A
K
I
A
K
T
A
H
K
N
G
S
T
Site 30
Y491
E
T
A
I
E
L
G
Y
L
T
A
E
Q
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation