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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN1
Full Name:
Calpain-1 catalytic subunit
Alias:
Calcium-activated neutral proteinase; Calcium-activated neutral proteinase 1; Calpain 1 (mu/I) large subunit; Calpain 1, (mu/I) large subunit; Calpain 1, large subunit; Calpain mu-type; Calpain, large polypeptide L1; Calpain-1 large subunit; CAN1; CANP; CANP 1; CANPL1; Cell proliferation-inducing protein 30; Micromolar-calpain; MuCANP; MuCL
Type:
Intracellular, Plasma membrane, Cytoplasm protein
Mass (Da):
81890
Number AA:
714
UniProt ID:
P07384
International Prot ID:
IPI00011285
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004198
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008284
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
R
H
E
N
A
I
K
Y
L
G
Q
D
Y
E
Q
Site 2
Y42
I
K
Y
L
G
Q
D
Y
E
Q
L
R
V
R
C
Site 3
S67
A
F
P
P
V
P
Q
S
L
G
Y
K
D
L
G
Site 4
Y70
P
V
P
Q
S
L
G
Y
K
D
L
G
P
N
S
Site 5
S77
Y
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
Site 6
S78
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
W
Site 7
T80
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
Site 8
Y81
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
Site 9
T89
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
Site 10
S93
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
Site 11
S140
R
V
V
P
H
G
Q
S
F
Q
N
G
Y
A
G
Site 12
Y145
G
Q
S
F
Q
N
G
Y
A
G
I
F
H
F
Q
Site 13
S180
G
K
L
V
F
V
H
S
A
E
G
N
E
F
W
Site 14
Y195
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
Site 15
S201
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
Site 16
Y202
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
S
Site 17
S206
N
G
S
Y
E
A
L
S
G
G
S
T
S
E
G
Site 18
T210
E
A
L
S
G
G
S
T
S
E
G
F
E
D
F
Site 19
T218
S
E
G
F
E
D
F
T
G
G
V
T
E
W
Y
Site 20
Y225
T
G
G
V
T
E
W
Y
E
L
R
K
A
P
S
Site 21
S232
Y
E
L
R
K
A
P
S
D
L
Y
Q
I
I
L
Site 22
Y235
R
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
Site 23
S246
L
K
A
L
E
R
G
S
L
L
G
C
S
I
D
Site 24
T277
K
G
H
A
Y
S
V
T
G
A
K
Q
V
N
Y
Site 25
Y284
T
G
A
K
Q
V
N
Y
R
G
Q
V
V
S
L
Site 26
S290
N
Y
R
G
Q
V
V
S
L
I
R
M
R
N
P
Site 27
T304
P
W
G
E
V
E
W
T
G
A
W
S
D
S
S
Site 28
S308
V
E
W
T
G
A
W
S
D
S
S
S
E
W
N
Site 29
S311
T
G
A
W
S
D
S
S
S
E
W
N
N
V
D
Site 30
S312
G
A
W
S
D
S
S
S
E
W
N
N
V
D
P
Site 31
Y320
E
W
N
N
V
D
P
Y
E
R
D
Q
L
R
V
Site 32
T346
R
D
F
M
R
E
F
T
R
L
E
I
C
N
L
Site 33
T354
R
L
E
I
C
N
L
T
P
D
A
L
K
S
R
Site 34
S360
L
T
P
D
A
L
K
S
R
T
I
R
K
W
N
Site 35
T362
P
D
A
L
K
S
R
T
I
R
K
W
N
T
T
Site 36
Y371
R
K
W
N
T
T
L
Y
E
G
T
W
R
R
G
Site 37
T374
N
T
T
L
Y
E
G
T
W
R
R
G
S
T
A
Site 38
S379
E
G
T
W
R
R
G
S
T
A
G
G
C
R
N
Site 39
T380
G
T
W
R
R
G
S
T
A
G
G
C
R
N
Y
Site 40
Y387
T
A
G
G
C
R
N
Y
P
A
T
F
W
V
N
Site 41
T404
F
K
I
R
L
D
E
T
D
D
P
D
D
Y
G
Site 42
Y410
E
T
D
D
P
D
D
Y
G
D
R
E
S
G
C
Site 43
S415
D
D
Y
G
D
R
E
S
G
C
S
F
V
L
A
Site 44
T440
R
F
G
R
D
M
E
T
I
G
F
A
V
Y
E
Site 45
S470
D
F
F
L
A
N
A
S
R
A
R
S
E
Q
F
Site 46
S474
A
N
A
S
R
A
R
S
E
Q
F
I
N
L
R
Site 47
S484
F
I
N
L
R
E
V
S
T
R
F
R
L
P
P
Site 48
T485
I
N
L
R
E
V
S
T
R
F
R
L
P
P
G
Site 49
T500
E
Y
V
V
V
P
S
T
F
E
P
N
K
E
G
Site 50
S539
L
P
D
E
Q
V
L
S
E
E
E
I
D
E
N
Site 51
S562
A
G
E
D
M
E
I
S
V
K
E
L
R
T
I
Site 52
S575
T
I
L
N
R
I
I
S
K
H
K
D
L
R
T
Site 53
T582
S
K
H
K
D
L
R
T
K
G
F
S
L
E
S
Site 54
S586
D
L
R
T
K
G
F
S
L
E
S
C
R
S
M
Site 55
S589
T
K
G
F
S
L
E
S
C
R
S
M
V
N
L
Site 56
S592
F
S
L
E
S
C
R
S
M
V
N
L
M
D
R
Site 57
Y620
L
W
N
R
I
R
N
Y
L
S
I
F
R
K
F
Site 58
S622
N
R
I
R
N
Y
L
S
I
F
R
K
F
D
L
Site 59
S632
R
K
F
D
L
D
K
S
G
S
M
S
A
Y
E
Site 60
S634
F
D
L
D
K
S
G
S
M
S
A
Y
E
M
R
Site 61
S636
L
D
K
S
G
S
M
S
A
Y
E
M
R
M
A
Site 62
Y638
K
S
G
S
M
S
A
Y
E
M
R
M
A
I
E
Site 63
S646
E
M
R
M
A
I
E
S
A
G
F
K
L
N
K
Site 64
Y656
F
K
L
N
K
K
L
Y
E
L
I
I
T
R
Y
Site 65
T661
K
L
Y
E
L
I
I
T
R
Y
S
E
P
D
L
Site 66
S664
E
L
I
I
T
R
Y
S
E
P
D
L
A
V
D
Site 67
T691
T
M
F
R
F
F
K
T
L
D
T
D
L
D
G
Site 68
T694
R
F
F
K
T
L
D
T
D
L
D
G
V
V
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation