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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CENPB
Full Name:
Major centromere autoantigen B
Alias:
CENP-B; Centromere protein B
Type:
DNA binding protein
Mass (Da):
65171
Number AA:
599
UniProt ID:
P07199
International Prot ID:
IPI00010388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000775
GO:0005634
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0003696
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0019219
GO:0019222
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
G
P
K
R
R
Q
L
T
F
R
E
K
S
R
I
Site 2
S14
Q
L
T
F
R
E
K
S
R
I
I
Q
E
V
E
Site 3
S40
R
R
F
N
I
P
P
S
T
L
S
T
I
L
K
Site 4
T41
R
F
N
I
P
P
S
T
L
S
T
I
L
K
N
Site 5
S43
N
I
P
P
S
T
L
S
T
I
L
K
N
K
R
Site 6
T44
I
P
P
S
T
L
S
T
I
L
K
N
K
R
A
Site 7
S55
N
K
R
A
I
L
A
S
E
R
K
Y
G
V
A
Site 8
Y59
I
L
A
S
E
R
K
Y
G
V
A
S
T
C
R
Site 9
S63
E
R
K
Y
G
V
A
S
T
C
R
K
T
N
K
Site 10
T64
R
K
Y
G
V
A
S
T
C
R
K
T
N
K
L
Site 11
T68
V
A
S
T
C
R
K
T
N
K
L
S
P
Y
D
Site 12
S72
C
R
K
T
N
K
L
S
P
Y
D
K
L
E
G
Site 13
Y74
K
T
N
K
L
S
P
Y
D
K
L
E
G
L
L
Site 14
T117
E
L
G
M
D
D
F
T
A
S
N
G
W
L
D
Site 15
S134
R
R
R
H
G
V
V
S
C
S
G
V
A
R
A
Site 16
T150
A
R
N
A
A
P
R
T
P
A
A
P
A
S
P
Site 17
S156
R
T
P
A
A
P
A
S
P
A
A
V
P
S
E
Site 18
S162
A
S
P
A
A
V
P
S
E
G
S
G
G
S
T
Site 19
S165
A
A
V
P
S
E
G
S
G
G
S
T
T
G
W
Site 20
T169
S
E
G
S
G
G
S
T
T
G
W
R
A
R
E
Site 21
S181
A
R
E
E
Q
P
P
S
V
A
E
G
Y
A
S
Site 22
S188
S
V
A
E
G
Y
A
S
Q
D
V
F
S
A
T
Site 23
S193
Y
A
S
Q
D
V
F
S
A
T
E
T
S
L
W
Site 24
T195
S
Q
D
V
F
S
A
T
E
T
S
L
W
Y
D
Site 25
T222
D
G
R
P
R
Q
A
T
Q
R
L
S
V
L
L
Site 26
S247
P
P
L
V
A
G
K
S
A
K
P
R
A
G
Q
Site 27
Y261
Q
A
G
L
P
C
D
Y
T
A
N
S
K
G
G
Site 28
T262
A
G
L
P
C
D
Y
T
A
N
S
K
G
G
V
Site 29
Y277
T
T
Q
A
L
A
K
Y
L
K
A
L
D
T
R
Site 30
T283
K
Y
L
K
A
L
D
T
R
M
A
A
E
S
R
Site 31
S289
D
T
R
M
A
A
E
S
R
R
V
L
L
L
A
Site 32
S303
A
G
R
L
A
A
Q
S
L
D
T
S
G
L
R
Site 33
S307
A
A
Q
S
L
D
T
S
G
L
R
H
V
Q
L
Site 34
S355
A
L
E
G
Q
D
P
S
G
L
Q
L
G
L
T
Site 35
T396
F
G
G
G
P
N
A
T
I
T
T
S
L
K
S
Site 36
T398
G
G
P
N
A
T
I
T
T
S
L
K
S
E
G
Site 37
S400
P
N
A
T
I
T
T
S
L
K
S
E
G
E
E
Site 38
S456
E
E
E
G
D
V
D
S
D
E
E
E
E
E
D
Site 39
S466
E
E
E
E
D
E
E
S
S
S
E
G
L
E
A
Site 40
S468
E
E
D
E
E
S
S
S
E
G
L
E
A
E
D
Site 41
Y490
A
G
G
S
F
G
A
Y
G
A
Q
E
E
A
Q
Site 42
S510
F
L
E
G
G
E
D
S
D
S
D
S
E
E
E
Site 43
S512
E
G
G
E
D
S
D
S
D
S
E
E
E
D
D
Site 44
S514
G
E
D
S
D
S
D
S
E
E
E
D
D
E
E
Site 45
S543
G
D
E
V
P
V
P
S
F
G
E
A
M
A
Y
Site 46
T559
A
M
V
K
R
Y
L
T
S
F
P
I
D
D
R
Site 47
S560
M
V
K
R
Y
L
T
S
F
P
I
D
D
R
V
Site 48
S569
P
I
D
D
R
V
Q
S
H
I
L
H
L
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation