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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALPP
Full Name:
Alkaline phosphatase, placental type
Alias:
Alkaline phosphatase Regan isozyme; ALP; EC 3.1.3.1; PLAP; PLAP-1; PPB1; PPBE
Type:
Plasma membrane, Integral membrane, Cell surface protein
Mass (Da):
57954
Number AA:
535
UniProt ID:
P05187
International Prot ID:
IPI00007289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0009986
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004035
GO:0000287
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S102
R
F
P
Y
V
A
L
S
K
T
Y
N
V
D
K
Site 2
T104
P
Y
V
A
L
S
K
T
Y
N
V
D
K
H
V
Site 3
S114
V
D
K
H
V
P
D
S
G
A
T
A
T
A
Y
Site 4
T117
H
V
P
D
S
G
A
T
A
T
A
Y
L
C
G
Site 5
T119
P
D
S
G
A
T
A
T
A
Y
L
C
G
V
K
Site 6
S135
N
F
Q
T
I
G
L
S
A
A
A
R
F
N
Q
Site 7
S164
R
A
K
K
A
G
K
S
V
G
V
V
T
T
T
Site 8
T170
K
S
V
G
V
V
T
T
T
R
V
Q
H
A
S
Site 9
S177
T
T
R
V
Q
H
A
S
P
A
G
T
Y
A
H
Site 10
T181
Q
H
A
S
P
A
G
T
Y
A
H
T
V
N
R
Site 11
Y191
H
T
V
N
R
N
W
Y
S
D
A
D
V
P
A
Site 12
S192
T
V
N
R
N
W
Y
S
D
A
D
V
P
A
S
Site 13
S199
S
D
A
D
V
P
A
S
A
R
Q
E
G
C
Q
Site 14
T210
E
G
C
Q
D
I
A
T
Q
L
I
S
N
M
D
Site 15
Y228
I
L
G
G
G
R
K
Y
M
F
R
M
G
T
P
Site 16
T234
K
Y
M
F
R
M
G
T
P
D
P
E
Y
P
D
Site 17
Y239
M
G
T
P
D
P
E
Y
P
D
D
Y
S
Q
G
Site 18
Y243
D
P
E
Y
P
D
D
Y
S
Q
G
G
T
R
L
Site 19
S244
P
E
Y
P
D
D
Y
S
Q
G
G
T
R
L
D
Site 20
Y268
A
K
R
Q
G
A
R
Y
V
W
N
R
T
E
L
Site 21
T273
A
R
Y
V
W
N
R
T
E
L
M
Q
A
S
L
Site 22
S279
R
T
E
L
M
Q
A
S
L
D
P
S
V
T
H
Site 23
S283
M
Q
A
S
L
D
P
S
V
T
H
L
M
G
L
Site 24
Y298
F
E
P
G
D
M
K
Y
E
I
H
R
D
S
T
Site 25
S304
K
Y
E
I
H
R
D
S
T
L
D
P
S
L
M
Site 26
T305
Y
E
I
H
R
D
S
T
L
D
P
S
L
M
E
Site 27
S309
R
D
S
T
L
D
P
S
L
M
E
M
T
E
A
Site 28
S322
E
A
A
L
R
L
L
S
R
N
P
R
G
F
F
Site 29
Y347
G
H
H
E
S
R
A
Y
R
A
L
T
E
T
I
Site 30
T351
S
R
A
Y
R
A
L
T
E
T
I
M
F
D
D
Site 31
T367
I
E
R
A
G
Q
L
T
S
E
E
D
T
L
S
Site 32
S368
E
R
A
G
Q
L
T
S
E
E
D
T
L
S
L
Site 33
T372
Q
L
T
S
E
E
D
T
L
S
L
V
T
A
D
Site 34
S374
T
S
E
E
D
T
L
S
L
V
T
A
D
H
S
Site 35
S385
A
D
H
S
H
V
F
S
F
G
G
Y
P
L
R
Site 36
Y410
K
A
R
D
R
K
A
Y
T
V
L
L
Y
G
N
Site 37
T411
A
R
D
R
K
A
Y
T
V
L
L
Y
G
N
G
Site 38
Y415
K
A
Y
T
V
L
L
Y
G
N
G
P
G
Y
V
Site 39
Y421
L
Y
G
N
G
P
G
Y
V
L
K
D
G
A
R
Site 40
T432
D
G
A
R
P
D
V
T
E
S
E
S
G
S
P
Site 41
S434
A
R
P
D
V
T
E
S
E
S
G
S
P
E
Y
Site 42
S436
P
D
V
T
E
S
E
S
G
S
P
E
Y
R
Q
Site 43
S438
V
T
E
S
E
S
G
S
P
E
Y
R
Q
Q
S
Site 44
Y441
S
E
S
G
S
P
E
Y
R
Q
Q
S
A
V
P
Site 45
S445
S
P
E
Y
R
Q
Q
S
A
V
P
L
D
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation