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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALPL
Full Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Alias:
Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP
Type:
Mass (Da):
57286
Number AA:
524
UniProt ID:
P05186
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004035
GO:0000287
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0031214
GO:0008152
GO:0033280
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
I
G
T
C
L
T
N
S
L
V
P
E
K
E
K
Site 2
Y28
E
K
E
K
D
P
K
Y
W
R
D
Q
A
Q
E
Site 3
Y39
Q
A
Q
E
T
L
K
Y
A
L
E
L
Q
K
L
Site 4
S98
K
F
P
F
V
A
L
S
K
T
Y
N
T
N
A
Site 5
T100
P
F
V
A
L
S
K
T
Y
N
T
N
A
Q
V
Site 6
S110
T
N
A
Q
V
P
D
S
A
G
T
A
T
A
Y
Site 7
T113
Q
V
P
D
S
A
G
T
A
T
A
Y
L
C
G
Site 8
T115
P
D
S
A
G
T
A
T
A
Y
L
C
G
V
K
Site 9
Y117
S
A
G
T
A
T
A
Y
L
C
G
V
K
A
N
Site 10
S137
V
S
A
A
T
E
R
S
R
C
N
T
T
Q
G
Site 11
T141
T
E
R
S
R
C
N
T
T
Q
G
N
E
V
T
Site 12
S160
W
A
K
D
A
G
K
S
V
G
I
V
T
T
T
Site 13
T165
G
K
S
V
G
I
V
T
T
T
R
V
N
H
A
Site 14
T166
K
S
V
G
I
V
T
T
T
R
V
N
H
A
T
Site 15
T173
T
T
R
V
N
H
A
T
P
S
A
A
Y
A
H
Site 16
Y187
H
S
A
D
R
D
W
Y
S
D
N
E
M
P
P
Site 17
S188
S
A
D
R
D
W
Y
S
D
N
E
M
P
P
E
Site 18
S198
E
M
P
P
E
A
L
S
Q
G
C
K
D
I
A
Site 19
Y206
Q
G
C
K
D
I
A
Y
Q
L
M
H
N
I
R
Site 20
Y225
I
M
G
G
G
R
K
Y
M
Y
P
K
N
K
T
Site 21
Y227
G
G
G
R
K
Y
M
Y
P
K
N
K
T
D
V
Site 22
T232
Y
M
Y
P
K
N
K
T
D
V
E
Y
E
S
D
Site 23
Y236
K
N
K
T
D
V
E
Y
E
S
D
E
K
A
R
Site 24
S238
K
T
D
V
E
Y
E
S
D
E
K
A
R
G
T
Site 25
T245
S
D
E
K
A
R
G
T
R
L
D
G
L
D
L
Site 26
T255
D
G
L
D
L
V
D
T
W
K
S
F
K
P
R
Site 27
T277
W
N
R
T
E
L
L
T
L
D
P
H
N
V
D
Site 28
Y285
L
D
P
H
N
V
D
Y
L
L
G
L
F
E
P
Site 29
Y297
F
E
P
G
D
M
Q
Y
E
L
N
R
N
N
V
Site 30
S308
R
N
N
V
T
D
P
S
L
S
E
M
V
V
V
Site 31
S364
R
A
I
G
Q
A
G
S
L
T
S
S
E
D
T
Site 32
S368
Q
A
G
S
L
T
S
S
E
D
T
L
T
V
V
Site 33
T371
S
L
T
S
S
E
D
T
L
T
V
V
T
A
D
Site 34
T373
T
S
S
E
D
T
L
T
V
V
T
A
D
H
S
Site 35
T384
A
D
H
S
H
V
F
T
F
G
G
Y
T
P
R
Site 36
Y388
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Site 37
S394
G
Y
T
P
R
G
N
S
I
F
G
L
A
P
M
Site 38
S403
F
G
L
A
P
M
L
S
D
T
D
K
K
P
F
Site 39
T405
L
A
P
M
L
S
D
T
D
K
K
P
F
T
A
Site 40
T411
D
T
D
K
K
P
F
T
A
I
L
Y
G
N
G
Site 41
Y415
K
P
F
T
A
I
L
Y
G
N
G
P
G
Y
K
Site 42
Y421
L
Y
G
N
G
P
G
Y
K
V
V
G
G
E
R
Site 43
S432
G
G
E
R
E
N
V
S
M
V
D
Y
A
H
N
Site 44
Y436
E
N
V
S
M
V
D
Y
A
H
N
N
Y
Q
A
Site 45
Y441
V
D
Y
A
H
N
N
Y
Q
A
Q
S
A
V
P
Site 46
T453
A
V
P
L
R
H
E
T
H
G
G
E
D
V
A
Site 47
Y479
H
G
V
H
E
Q
N
Y
V
P
H
V
M
A
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation