KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CYP1A2
Full Name:
Cytochrome P450 1A2
Alias:
CP12; CP1A2; Cytochrome P450, family 1, subfamily A, polypeptide 2; EC 1.14.14.1; P3-450; P450(PA)
Type:
Membrane, Endoplasmic reticulum, Microsome, Endoplasmic reticulum membrane protein
Mass (Da):
58294
Number AA:
515
UniProt ID:
P05177
International Prot ID:
IPI00719591
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0019898
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0070330
GO:0032451
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0009820
GO:0017144
GO:0016098
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
R
V
P
K
G
L
K
S
P
P
E
P
W
G
W
Site 2
S66
K
N
P
H
L
A
L
S
R
M
S
Q
R
Y
G
Site 3
S69
H
L
A
L
S
R
M
S
Q
R
Y
G
D
V
L
Site 4
Y72
L
S
R
M
S
Q
R
Y
G
D
V
L
Q
I
R
Site 5
S82
V
L
Q
I
R
I
G
S
T
P
V
L
V
L
S
Site 6
Y112
F
K
G
R
P
D
L
Y
T
S
T
L
I
T
D
Site 7
T113
K
G
R
P
D
L
Y
T
S
T
L
I
T
D
G
Site 8
T115
R
P
D
L
Y
T
S
T
L
I
T
D
G
Q
S
Site 9
S122
T
L
I
T
D
G
Q
S
L
T
F
S
T
D
S
Site 10
T124
I
T
D
G
Q
S
L
T
F
S
T
D
S
G
P
Site 11
S126
D
G
Q
S
L
T
F
S
T
D
S
G
P
V
W
Site 12
S129
S
L
T
F
S
T
D
S
G
P
V
W
A
A
R
Site 13
S148
Q
N
A
L
N
T
F
S
I
A
S
D
P
A
S
Site 14
S151
L
N
T
F
S
I
A
S
D
P
A
S
S
S
S
Site 15
S155
S
I
A
S
D
P
A
S
S
S
S
C
Y
L
E
Site 16
S157
A
S
D
P
A
S
S
S
S
C
Y
L
E
E
H
Site 17
S158
S
D
P
A
S
S
S
S
C
Y
L
E
E
H
V
Site 18
Y160
P
A
S
S
S
S
C
Y
L
E
E
H
V
S
K
Site 19
S166
C
Y
L
E
E
H
V
S
K
E
A
K
A
L
I
Site 20
Y189
G
P
G
H
F
D
P
Y
N
Q
V
V
V
S
V
Site 21
S212
F
G
Q
H
F
P
E
S
S
D
E
M
L
S
L
Site 22
S213
G
Q
H
F
P
E
S
S
D
E
M
L
S
L
V
Site 23
S218
E
S
S
D
E
M
L
S
L
V
K
N
T
H
E
Site 24
T229
N
T
H
E
F
V
E
T
A
S
S
G
N
P
L
Site 25
S232
E
F
V
E
T
A
S
S
G
N
P
L
D
F
F
Site 26
Y272
Q
K
T
V
Q
E
H
Y
Q
D
F
D
K
N
S
Site 27
S279
Y
Q
D
F
D
K
N
S
V
R
D
I
T
G
A
Site 28
T284
K
N
S
V
R
D
I
T
G
A
L
F
K
H
S
Site 29
S298
S
K
K
G
P
R
A
S
G
N
L
I
P
Q
E
Site 30
T349
K
I
Q
K
E
L
D
T
V
I
G
R
E
R
R
Site 31
S360
R
E
R
R
P
R
L
S
D
R
P
Q
L
P
Y
Site 32
Y367
S
D
R
P
Q
L
P
Y
L
E
A
F
I
L
E
Site 33
T385
H
S
S
F
L
P
F
T
I
P
H
S
T
T
R
Site 34
S389
L
P
F
T
I
P
H
S
T
T
R
D
T
T
L
Site 35
T390
P
F
T
I
P
H
S
T
T
R
D
T
T
L
N
Site 36
T394
P
H
S
T
T
R
D
T
T
L
N
G
F
Y
I
Site 37
T395
H
S
T
T
R
D
T
T
L
N
G
F
Y
I
P
Site 38
S425
P
E
L
W
E
D
P
S
E
F
R
P
E
R
F
Site 39
T434
F
R
P
E
R
F
L
T
A
D
G
T
A
I
N
Site 40
T438
R
F
L
T
A
D
G
T
A
I
N
K
P
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation