KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CFI
Full Name:
Complement factor I
Alias:
C3B/C4B inactivator; C3b-INA; C3b-inactivator; CFAI; EC 3.4.21.45; Factor I; FI; I factor (complement); IF; KAF; Konglutinogen-activating factor; Light chain of factor I
Type:
Protease; EC 3.4.21.45
Mass (Da):
65720
Number AA:
583
UniProt ID:
P05156
International Prot ID:
IPI00291867
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005044
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006958
GO:0045087
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
H
L
R
F
C
K
V
T
Y
T
S
Q
E
D
L
Site 2
Y22
L
R
F
C
K
V
T
Y
T
S
Q
E
D
L
V
Site 3
S24
F
C
K
V
T
Y
T
S
Q
E
D
L
V
E
K
Site 4
Y38
K
K
C
L
A
K
K
Y
T
H
L
S
C
D
K
Site 5
Y65
T
C
V
C
K
L
P
Y
Q
C
P
K
N
G
T
Site 6
T77
N
G
T
A
V
C
A
T
N
R
R
S
F
P
T
Site 7
T84
T
N
R
R
S
F
P
T
Y
C
Q
Q
K
S
L
Site 8
Y85
N
R
R
S
F
P
T
Y
C
Q
Q
K
S
L
E
Site 9
S113
C
T
A
E
G
K
F
S
V
S
L
K
H
G
N
Site 10
S115
A
E
G
K
F
S
V
S
L
K
H
G
N
T
D
Site 11
S123
L
K
H
G
N
T
D
S
E
G
I
V
E
V
K
Site 12
T137
K
L
V
D
Q
D
K
T
M
F
I
C
K
S
S
Site 13
T165
G
F
Q
Q
G
A
D
T
Q
R
R
F
K
L
S
Site 14
S172
T
Q
R
R
F
K
L
S
D
L
S
I
N
S
T
Site 15
S175
R
F
K
L
S
D
L
S
I
N
S
T
E
C
L
Site 16
T179
S
D
L
S
I
N
S
T
E
C
L
H
V
H
C
Site 17
S192
H
C
R
G
L
E
T
S
L
A
E
C
T
F
T
Site 18
T197
E
T
S
L
A
E
C
T
F
T
K
R
R
T
M
Site 19
T199
S
L
A
E
C
T
F
T
K
R
R
T
M
G
Y
Site 20
Y206
T
K
R
R
T
M
G
Y
Q
D
F
A
D
V
V
Site 21
Y234
F
Q
C
V
N
G
K
Y
I
S
Q
M
K
A
C
Site 22
Y276
G
V
C
I
P
S
Q
Y
Q
C
N
G
E
V
D
Site 23
T286
N
G
E
V
D
C
I
T
G
E
D
E
V
G
C
Site 24
S320
A
E
R
R
R
I
K
S
L
L
P
K
L
S
C
Site 25
S326
K
S
L
L
P
K
L
S
C
G
V
K
N
R
M
Site 26
Y421
R
I
I
F
H
E
N
Y
N
A
G
T
Y
Q
N
Site 27
S483
K
D
N
E
R
V
F
S
L
Q
W
G
E
V
K
Site 28
Y504
K
F
Y
G
N
R
F
Y
E
K
E
M
E
C
A
Site 29
T513
K
E
M
E
C
A
G
T
Y
D
G
S
I
D
A
Site 30
S517
C
A
G
T
Y
D
G
S
I
D
A
C
K
G
D
Site 31
Y559
K
P
E
F
P
G
V
Y
T
K
V
A
N
Y
F
Site 32
Y565
V
Y
T
K
V
A
N
Y
F
D
W
I
S
Y
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation