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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SERPINB2
Full Name:
Plasminogen activator inhibitor 2
Alias:
Monocyte Arg-serpin;Placental plasminogen activator inhibitor;Serpin B2;Urokinase inhibitor
Type:
Mass (Da):
46596
Number AA:
415
UniProt ID:
P05120
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
F
K
H
L
A
K
A
S
P
T
Q
N
L
F
L
Site 2
S31
P
T
Q
N
L
F
L
S
P
W
S
I
S
S
T
Site 3
Y43
S
S
T
M
A
M
V
Y
M
G
S
R
G
S
T
Site 4
S49
V
Y
M
G
S
R
G
S
T
E
D
Q
M
A
K
Site 5
T50
Y
M
G
S
R
G
S
T
E
D
Q
M
A
K
V
Site 6
T69
E
V
G
A
N
A
V
T
P
M
T
P
E
N
F
Site 7
T72
A
N
A
V
T
P
M
T
P
E
N
F
T
S
C
Site 8
Y90
Q
Q
I
Q
K
G
S
Y
P
D
A
I
L
Q
A
Site 9
S105
Q
A
A
D
K
I
H
S
S
F
R
S
L
S
S
Site 10
S106
A
A
D
K
I
H
S
S
F
R
S
L
S
S
A
Site 11
S109
K
I
H
S
S
F
R
S
L
S
S
A
I
N
A
Site 12
S111
H
S
S
F
R
S
L
S
S
A
I
N
A
S
T
Site 13
S112
S
S
F
R
S
L
S
S
A
I
N
A
S
T
G
Site 14
Y121
I
N
A
S
T
G
N
Y
L
L
E
S
V
N
K
Site 15
S125
T
G
N
Y
L
L
E
S
V
N
K
L
F
G
E
Site 16
S134
N
K
L
F
G
E
K
S
A
S
F
R
E
E
Y
Site 17
S136
L
F
G
E
K
S
A
S
F
R
E
E
Y
I
R
Site 18
Y141
S
A
S
F
R
E
E
Y
I
R
L
C
Q
K
Y
Site 19
Y148
Y
I
R
L
C
Q
K
Y
Y
S
S
E
P
Q
A
Site 20
S151
L
C
Q
K
Y
Y
S
S
E
P
Q
A
V
D
F
Site 21
S171
E
A
R
K
K
I
N
S
W
V
K
T
Q
T
K
Site 22
T175
K
I
N
S
W
V
K
T
Q
T
K
G
K
I
P
Site 23
S189
P
N
L
L
P
E
G
S
V
D
G
D
T
R
M
Site 24
T194
E
G
S
V
D
G
D
T
R
M
V
L
V
N
A
Site 25
T210
Y
F
K
G
K
W
K
T
P
F
E
K
K
L
N
Site 26
Y220
E
K
K
L
N
G
L
Y
P
F
R
V
N
S
A
Site 27
S226
L
Y
P
F
R
V
N
S
A
Q
R
T
P
V
Q
Site 28
T230
R
V
N
S
A
Q
R
T
P
V
Q
M
M
Y
L
Site 29
Y236
R
T
P
V
Q
M
M
Y
L
R
E
K
L
N
I
Site 30
S276
P
D
E
I
A
D
V
S
T
G
L
E
L
L
E
Site 31
S284
T
G
L
E
L
L
E
S
E
I
T
Y
D
K
L
Site 32
T287
E
L
L
E
S
E
I
T
Y
D
K
L
N
K
W
Site 33
Y288
L
L
E
S
E
I
T
Y
D
K
L
N
K
W
T
Site 34
S296
D
K
L
N
K
W
T
S
K
D
K
M
A
E
D
Site 35
Y308
A
E
D
E
V
E
V
Y
I
P
Q
F
K
L
E
Site 36
Y318
Q
F
K
L
E
E
H
Y
E
L
R
S
I
L
R
Site 37
S322
E
E
H
Y
E
L
R
S
I
L
R
S
M
G
M
Site 38
S326
E
L
R
S
I
L
R
S
M
G
M
E
D
A
F
Site 39
S341
N
K
G
R
A
N
F
S
G
M
S
E
R
N
D
Site 40
S344
R
A
N
F
S
G
M
S
E
R
N
D
L
F
L
Site 41
S352
E
R
N
D
L
F
L
S
E
V
F
H
Q
A
M
Site 42
T378
A
G
T
G
G
V
M
T
G
R
T
G
H
G
G
Site 43
T381
G
G
V
M
T
G
R
T
G
H
G
G
P
Q
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation