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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH2
Full Name:
Aldehyde dehydrogenase, mitochondrial
Alias:
Acetaldehyde dehydrogenase 2; Aldehyde dehydrogenase 2 family (mitochondrial); Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; ALDM; EC 1.2.1.3
Type:
Carbohydrate Metabolism - pyruvate; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.1.3; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - ascorbate and aldarate; Oxidoreductase; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - propanoate
Mass (Da):
56381
Number AA:
517
UniProt ID:
P05091
International Prot ID:
IPI00006663
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004029
GO:0004030
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0006066
GO:0005975
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T53
H
D
A
V
S
R
K
T
F
P
T
V
N
P
S
Site 2
T56
V
S
R
K
T
F
P
T
V
N
P
S
T
G
E
Site 3
S91
R
A
A
F
Q
L
G
S
P
W
R
R
M
D
A
Site 4
S99
P
W
R
R
M
D
A
S
H
R
G
R
L
L
N
Site 5
T117
D
L
I
E
R
D
R
T
Y
L
A
A
L
E
T
Site 6
T124
T
Y
L
A
A
L
E
T
L
D
N
G
K
P
Y
Site 7
Y131
T
L
D
N
G
K
P
Y
V
I
S
Y
L
V
D
Site 8
Y135
G
K
P
Y
V
I
S
Y
L
V
D
L
D
M
V
Site 9
Y148
M
V
L
K
C
L
R
Y
Y
A
G
W
A
D
K
Site 10
Y149
V
L
K
C
L
R
Y
Y
A
G
W
A
D
K
Y
Site 11
Y156
Y
A
G
W
A
D
K
Y
H
G
K
T
I
P
I
Site 12
S169
P
I
D
G
D
F
F
S
Y
T
R
H
E
P
V
Site 13
Y170
I
D
G
D
F
F
S
Y
T
R
H
E
P
V
G
Site 14
T171
D
G
D
F
F
S
Y
T
R
H
E
P
V
G
V
Site 15
T283
S
S
N
L
K
R
V
T
L
E
L
G
G
K
S
Site 16
S290
T
L
E
L
G
G
K
S
P
N
I
I
M
S
D
Site 17
Y332
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
Site 18
S339
Y
D
E
F
V
E
R
S
V
A
R
A
K
S
R
Site 19
S345
R
S
V
A
R
A
K
S
R
V
V
G
N
P
F
Site 20
S354
V
V
G
N
P
F
D
S
K
T
E
Q
G
P
Q
Site 21
T356
G
N
P
F
D
S
K
T
E
Q
G
P
Q
V
D
Site 22
T365
Q
G
P
Q
V
D
E
T
Q
F
K
K
I
L
G
Site 23
T376
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
Site 24
Y396
G
I
A
A
D
R
G
Y
F
I
Q
P
T
V
F
Site 25
T401
R
G
Y
F
I
Q
P
T
V
F
G
D
V
Q
D
Site 26
T411
G
D
V
Q
D
G
M
T
I
A
K
E
E
I
F
Site 27
Y442
G
R
A
N
N
S
T
Y
G
L
A
A
A
V
F
Site 28
T450
G
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Site 29
Y458
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
Site 30
S460
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
G
T
Site 31
S480
Y
D
V
F
G
A
Q
S
P
F
G
G
Y
K
M
Site 32
Y485
A
Q
S
P
F
G
G
Y
K
M
S
G
S
G
R
Site 33
S488
P
F
G
G
Y
K
M
S
G
S
G
R
E
L
G
Site 34
S490
G
G
Y
K
M
S
G
S
G
R
E
L
G
E
Y
Site 35
Y497
S
G
R
E
L
G
E
Y
G
L
Q
A
Y
T
E
Site 36
Y502
G
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
Site 37
T503
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
V
Site 38
T507
Q
A
Y
T
E
V
K
T
V
T
V
K
V
P
Q
Site 39
T509
Y
T
E
V
K
T
V
T
V
K
V
P
Q
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation