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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWF
Full Name:
von Willebrand factor
Alias:
von Willebrand antigen II
Type:
Mass (Da):
309263
Number AA:
2813
UniProt ID:
P04275
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
Site 2
S30
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
Site 3
S31
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
Site 4
T32
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
Site 5
S36
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
Site 6
T45
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
Site 7
Y51
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Site 8
S69
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Site 9
S71
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
Site 10
S83
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
Site 11
T101
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
Site 12
S110
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
Site 13
Y113
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
Site 14
Y119
P
Y
A
S
K
G
L
Y
L
E
T
E
A
G
Y
Site 15
Y126
Y
L
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Site 16
Y127
L
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
Site 17
Y134
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
Site 18
S151
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
Site 19
Y154
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
Site 20
T175
F
A
E
D
D
F
M
T
Q
E
G
T
L
T
S
Site 21
T181
M
T
Q
E
G
T
L
T
S
D
P
Y
D
F
A
Site 22
Y185
G
T
L
T
S
D
P
Y
D
F
A
N
S
W
A
Site 23
S190
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Site 24
S204
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
Site 25
S207
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
Site 26
S208
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
Site 27
S209
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
Site 28
S213
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
Site 29
S214
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
Site 30
S230
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
Site 31
Y283
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
Site 32
S330
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
Site 33
T346
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
Site 34
S353
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
Site 35
Y357
C
V
H
S
G
K
R
Y
P
P
G
T
S
L
S
Site 36
T361
G
K
R
Y
P
P
G
T
S
L
S
R
D
C
N
Site 37
S362
K
R
Y
P
P
G
T
S
L
S
R
D
C
N
T
Site 38
S364
Y
P
P
G
T
S
L
S
R
D
C
N
T
C
I
Site 39
T391
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
Site 40
Y403
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Site 41
S422
A
R
D
C
Q
D
H
S
F
S
I
V
I
E
T
Site 42
T441
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
Site 43
S443
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
Site 44
S454
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
Site 45
T485
G
D
L
R
I
Q
H
T
V
T
A
S
V
R
L
Site 46
S489
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
Site 47
S493
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
Site 48
Y494
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
Site 49
Y527
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
Site 50
T537
N
Q
G
D
D
F
L
T
P
S
G
L
A
E
P
Site 51
S539
G
D
D
F
L
T
P
S
G
L
A
E
P
R
V
Site 52
S567
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
Site 53
T577
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
Site 54
S580
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
Site 55
S600
E
A
C
H
R
A
V
S
P
L
P
Y
L
R
N
Site 56
Y604
R
A
V
S
P
L
P
Y
L
R
N
C
R
Y
D
Site 57
Y610
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
Site 58
Y658
N
C
P
K
G
Q
V
Y
L
Q
C
G
T
P
C
Site 59
S671
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
Site 60
S673
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
Site 61
Y674
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
Site 62
Y710
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
Site 63
S754
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
Site 64
S755
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
Site 65
S758
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
Site 66
S761
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
Site 67
S764
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
Site 68
S766
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
Site 69
T791
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
Site 70
Y897
Q
Y
V
L
V
Q
D
Y
C
G
S
N
P
G
T
Site 71
T904
Y
C
G
S
N
P
G
T
F
R
I
L
V
G
N
Site 72
S918
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
Site 73
T926
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
Site 74
T951
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
Site 75
S981
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Site 76
Y988
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
Site 77
T1008
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
Site 78
S1024
D
P
V
D
F
G
N
S
W
K
V
S
S
Q
C
Site 79
S1028
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
Site 80
S1029
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
Site 81
S1041
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
Site 82
S1042
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
Site 83
T1045
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Site 84
S1058
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
Site 85
S1059
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
Site 86
T1064
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
Site 87
S1065
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
Site 88
Y1080
K
L
V
D
P
E
P
Y
L
D
V
C
I
Y
D
Site 89
T1119
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
Site 90
S1129
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
Site 91
Y1140
R
N
L
R
E
N
G
Y
E
C
E
W
R
Y
N
Site 92
S1208
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
Site 93
T1213
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
Site 94
S1217
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
Site 95
S1253
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
Site 96
T1256
D
A
P
V
S
P
T
T
L
Y
V
E
D
I
S
Site 97
Y1258
P
V
S
P
T
T
L
Y
V
E
D
I
S
E
P
Site 98
S1263
T
L
Y
V
E
D
I
S
E
P
P
L
H
D
F
Site 99
Y1271
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
Site 100
S1289
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
Site 101
S1310
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
Site 102
Y1321
V
R
V
A
V
V
E
Y
H
D
G
S
H
A
Y
Site 103
S1338
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Site 104
S1345
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Site 105
Y1349
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
Site 106
S1352
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
Site 107
S1356
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
Site 108
S1358
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
Site 109
S1370
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
Site 110
S1394
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Site 111
Y1400
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
Site 112
S1442
N
K
A
F
V
L
S
S
V
D
E
L
E
Q
Q
Site 113
S1455
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
Site 114
Y1456
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
Site 115
T1468
A
P
E
A
P
P
P
T
L
P
P
H
M
A
Q
Site 116
T1487
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
Site 117
S1534
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Site 118
T1538
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
Site 119
T1547
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
Site 120
Y1550
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
Site 121
S1553
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
Site 122
S1557
Y
P
F
S
E
A
Q
S
K
G
D
I
L
Q
R
Site 123
T1578
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
Site 124
Y1584
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
Site 125
S1589
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
Site 126
S1593
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
Site 127
Y1605
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
Site 128
T1608
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
Site 129
S1613
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
Site 130
T1656
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
Site 131
T1679
G
E
G
L
Q
I
P
T
L
S
P
A
P
D
C
Site 132
S1681
G
L
Q
I
P
T
L
S
P
A
P
D
C
S
Q
Site 133
S1705
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
Site 134
Y1706
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
Site 135
S1712
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
Site 136
S1719
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
Site 137
S1756
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
Site 138
S1768
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
Site 139
T1782
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
Site 140
S1817
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
Site 141
Y1831
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
Site 142
S1846
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
Site 143
T1859
Q
R
I
E
D
L
P
T
M
V
T
L
G
N
S
Site 144
T1894
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
Site 145
T1910
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
Site 146
S1914
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
R
Site 147
S1926
C
D
R
G
L
R
P
S
C
P
N
S
Q
S
P
Site 148
S1930
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
Site 149
S1932
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
Site 150
T1960
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
Site 151
T1969
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
Site 152
S1973
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
Site 153
Y1974
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
E
Site 154
S1994
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
Site 155
S2004
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
Site 156
S2010
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
Site 157
S2013
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
Site 158
S2030
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
Site 159
T2060
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
Site 160
T2062
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
Site 161
S2073
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
Site 162
T2076
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
Site 163
S2079
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
Site 164
T2102
D
F
M
L
R
D
G
T
V
T
T
D
W
K
T
Site 165
T2104
M
L
R
D
G
T
V
T
T
D
W
K
T
L
V
Site 166
T2109
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Site 167
T2115
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
Site 168
S2225
R
H
C
D
G
N
V
S
S
C
G
D
H
P
S
Site 169
S2226
H
C
D
G
N
V
S
S
C
G
D
H
P
S
E
Site 170
S2232
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
Site 171
S2247
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
Site 172
T2292
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
Site 173
Y2323
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
Site 174
T2347
C
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
Site 175
T2349
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
Site 176
S2371
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
Site 177
S2374
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
Site 178
T2382
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
Site 179
T2386
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
Site 180
S2469
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
Site 181
S2476
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
Site 182
Y2483
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
Site 183
T2503
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Site 184
S2505
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
Site 185
S2510
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
Site 186
S2512
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Site 187
S2513
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
Site 188
S2516
D
S
Q
S
S
W
K
S
V
G
S
Q
W
A
S
Site 189
S2519
S
S
W
K
S
V
G
S
Q
W
A
S
P
E
N
Site 190
S2523
S
V
G
S
Q
W
A
S
P
E
N
P
C
L
I
Site 191
S2548
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
Site 192
T2623
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Site 193
T2637
G
Y
K
E
E
N
N
T
G
E
C
C
G
R
C
Site 194
T2650
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
Site 195
T2666
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
Site 196
Y2684
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
Site 197
T2728
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
Site 198
Y2733
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
Site 199
S2741
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Site 200
Y2749
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
Site 201
Y2760
K
C
A
S
K
A
M
Y
S
I
D
I
N
D
V
Site 202
S2775
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Site 203
T2779
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
Site 204
S2807
N
A
M
E
C
K
C
S
P
R
K
C
S
K
_
Site 205
S2812
K
C
S
P
R
K
C
S
K
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation