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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRNP
Full Name:
Major prion protein
Alias:
ASCR; CD230; CJD; Creutzfeldt-Jakob disease; Fatal familial insomnia; Gerstmann-Strausler-Scheinker syndrome; GSS; MGC26679; P27-30; PRIO; Prion protein; Prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Type:
Microtubule binding protein
Mass (Da):
27643
Number AA:
253
UniProt ID:
P04156
International Prot ID:
IPI00022284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031225
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0042802
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0006878
GO:0008152
GO:0051260
Phosida
TranscriptoNet
STRING
Kinexus Products
Major prion protein (W99-H111, human) M110L protein; Williamson 2 (PrP) peptide - Powder PE-03AAA95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAA95#Major prion protein (K23-T33, human) protein; Williamson 1 (PrP) peptide, biotinylated peptide - Powder PE-03AAM80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-03AAM80
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
Site 2
Y38
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
Site 3
S43
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
Site 4
Y49
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
Site 5
S97
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
Site 6
T107
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
Site 7
Y145
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
Site 8
Y149
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Site 9
Y150
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
Site 10
Y157
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
Site 11
Y162
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
Site 12
Y163
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
Site 13
Y169
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
Site 14
T201
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
Site 15
Y218
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Site 16
S222
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
Site 17
Y225
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
Site 18
Y226
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
Site 19
S230
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
Site 20
S231
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation