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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LTF
Full Name:
Lactotransferrin
Alias:
GIG12; HLF2; kaliocin-1; lactoferrin; lactotransferrin; LF; talalactoferrin; TRFL
Type:
EC 3.4.21.-; Protease; Secreted protein
Mass (Da):
78182
Number AA:
710
UniProt ID:
P02788
International Prot ID:
IPI00298860
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0030141
Uniprot
OncoNet
Molecular Function:
GO:0008199
GO:0008201
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006879
GO:0042742
GO:0006959
Phosida
TranscriptoNet
STRING
Kinexus Products
Lactoferrin (E354 - V365, human) FAM labeled peptide - Powder PE-07AAD95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-07AAD95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
C
L
A
G
R
R
R
S
V
Q
W
C
A
V
S
Site 2
S54
K
V
R
G
P
P
V
S
C
I
K
R
D
S
P
Site 3
T77
E
N
R
A
D
A
V
T
L
D
G
G
F
I
Y
Site 4
T103
V
A
A
E
V
Y
G
T
E
R
Q
P
R
T
H
Site 5
Y111
E
R
Q
P
R
T
H
Y
Y
A
V
A
V
V
K
Site 6
Y112
R
Q
P
R
T
H
Y
Y
A
V
A
V
V
K
K
Site 7
S122
A
V
V
K
K
G
G
S
F
Q
L
N
E
L
Q
Site 8
S133
N
E
L
Q
G
L
K
S
C
H
T
G
L
R
R
Site 9
T136
Q
G
L
K
S
C
H
T
G
L
R
R
T
A
G
Site 10
T158
L
R
P
F
L
N
W
T
G
P
P
E
P
I
E
Site 11
S204
E
N
K
C
A
F
S
S
Q
E
P
Y
F
S
Y
Site 12
Y208
A
F
S
S
Q
E
P
Y
F
S
Y
S
G
A
F
Site 13
S210
S
S
Q
E
P
Y
F
S
Y
S
G
A
F
K
C
Site 14
Y211
S
Q
E
P
Y
F
S
Y
S
G
A
F
K
C
L
Site 15
S212
Q
E
P
Y
F
S
Y
S
G
A
F
K
C
L
R
Site 16
S238
S
T
V
F
E
D
L
S
D
E
A
E
R
D
E
Site 17
Y246
D
E
A
E
R
D
E
Y
E
L
L
C
P
D
N
Site 18
T254
E
L
L
C
P
D
N
T
R
K
P
V
D
K
F
Site 19
S278
S
H
A
V
V
A
R
S
V
N
G
K
E
D
A
Site 20
S302
E
K
F
G
K
D
K
S
P
K
F
Q
L
F
G
Site 21
S310
P
K
F
Q
L
F
G
S
P
S
G
Q
K
D
L
Site 22
S312
F
Q
L
F
G
S
P
S
G
Q
K
D
L
L
F
Site 23
S335
R
V
P
P
R
I
D
S
G
L
Y
L
G
S
G
Site 24
Y338
P
R
I
D
S
G
L
Y
L
G
S
G
Y
F
T
Site 25
T345
Y
L
G
S
G
Y
F
T
A
I
Q
N
L
R
K
Site 26
S353
A
I
Q
N
L
R
K
S
E
E
E
V
A
A
R
Site 27
S381
L
R
K
C
N
Q
W
S
G
L
S
E
G
S
V
Site 28
S384
C
N
Q
W
S
G
L
S
E
G
S
V
T
C
S
Site 29
S387
W
S
G
L
S
E
G
S
V
T
C
S
S
A
S
Site 30
T389
G
L
S
E
G
S
V
T
C
S
S
A
S
T
T
Site 31
S391
S
E
G
S
V
T
C
S
S
A
S
T
T
E
D
Site 32
S412
K
G
E
A
D
A
M
S
L
D
G
G
Y
V
Y
Site 33
Y434
V
P
V
L
A
E
N
Y
K
S
Q
Q
S
S
D
Site 34
S436
V
L
A
E
N
Y
K
S
Q
Q
S
S
D
P
D
Site 35
S440
N
Y
K
S
Q
Q
S
S
D
P
D
P
N
C
V
Site 36
Y454
V
D
R
P
V
E
G
Y
L
A
V
A
V
V
R
Site 37
S463
A
V
A
V
V
R
R
S
D
T
S
L
T
W
N
Site 38
T465
A
V
V
R
R
S
D
T
S
L
T
W
N
S
V
Site 39
S466
V
V
R
R
S
D
T
S
L
T
W
N
S
V
K
Site 40
T468
R
R
S
D
T
S
L
T
W
N
S
V
K
G
K
Site 41
S477
N
S
V
K
G
K
K
S
C
H
T
A
V
D
R
Site 42
T499
M
G
L
L
F
N
Q
T
G
S
C
K
F
D
E
Site 43
S501
L
L
F
N
Q
T
G
S
C
K
F
D
E
Y
F
Site 44
Y507
G
S
C
K
F
D
E
Y
F
S
Q
S
C
A
P
Site 45
S509
C
K
F
D
E
Y
F
S
Q
S
C
A
P
G
S
Site 46
S511
F
D
E
Y
F
S
Q
S
C
A
P
G
S
D
P
Site 47
S516
S
Q
S
C
A
P
G
S
D
P
R
S
N
L
C
Site 48
Y544
V
P
N
S
N
E
R
Y
Y
G
Y
T
G
A
F
Site 49
Y545
P
N
S
N
E
R
Y
Y
G
Y
T
G
A
F
R
Site 50
Y547
S
N
E
R
Y
Y
G
Y
T
G
A
F
R
C
L
Site 51
T603
D
G
K
R
K
P
V
T
E
A
R
S
C
H
L
Site 52
S644
A
K
F
G
R
N
G
S
D
C
P
D
K
F
C
Site 53
T666
N
L
L
F
N
D
N
T
E
C
L
A
R
L
H
Site 54
T676
L
A
R
L
H
G
K
T
T
Y
E
K
Y
L
G
Site 55
T677
A
R
L
H
G
K
T
T
Y
E
K
Y
L
G
P
Site 56
Y678
R
L
H
G
K
T
T
Y
E
K
Y
L
G
P
Q
Site 57
Y681
G
K
T
T
Y
E
K
Y
L
G
P
Q
Y
V
A
Site 58
Y686
E
K
Y
L
G
P
Q
Y
V
A
G
I
T
N
L
Site 59
S697
I
T
N
L
K
K
C
S
T
S
P
L
L
E
A
Site 60
S699
N
L
K
K
C
S
T
S
P
L
L
E
A
C
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation