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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTA1
Full Name:
Spectrin alpha chain, erythrocyte
Alias:
EL2; Elliptocytosis 2; Erythroid alpha-spectrin; Spectrin, alpha, erythrocytic 1; SPTA
Type:
Cytoskeletal protein
Mass (Da):
279916
Number AA:
2418
UniProt ID:
P02549
International Prot ID:
IPI00220741
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0031235
GO:0008091
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005509
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0007015
GO:0008360
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
Q
F
P
K
E
T
V
V
E
S
S
G
P
Site 2
T20
S
G
P
K
V
L
E
T
A
E
E
I
Q
E
R
Site 3
T33
E
R
R
Q
E
V
L
T
R
Y
Q
S
F
K
E
Site 4
Y35
R
Q
E
V
L
T
R
Y
Q
S
F
K
E
R
V
Site 5
S37
E
V
L
T
R
Y
Q
S
F
K
E
R
V
A
E
Site 6
S52
R
G
Q
K
L
E
D
S
Y
H
L
Q
V
F
K
Site 7
Y53
G
Q
K
L
E
D
S
Y
H
L
Q
V
F
K
R
Site 8
S80
V
N
I
L
T
D
K
S
Y
E
D
P
T
N
I
Site 9
Y81
N
I
L
T
D
K
S
Y
E
D
P
T
N
I
Q
Site 10
T85
D
K
S
Y
E
D
P
T
N
I
Q
G
K
Y
Q
Site 11
Y91
P
T
N
I
Q
G
K
Y
Q
K
H
Q
S
L
E
Site 12
S96
G
K
Y
Q
K
H
Q
S
L
E
A
E
V
Q
T
Site 13
S105
E
A
E
V
Q
T
K
S
R
L
M
S
E
L
E
Site 14
S109
Q
T
K
S
R
L
M
S
E
L
E
K
T
R
E
Site 15
T114
L
M
S
E
L
E
K
T
R
E
E
R
F
T
M
Site 16
T120
K
T
R
E
E
R
F
T
M
G
H
S
A
H
E
Site 17
T147
W
D
L
L
L
E
L
T
L
E
K
G
D
Q
L
Site 18
Y163
R
A
L
K
F
Q
Q
Y
V
Q
E
C
A
D
I
Site 19
T182
G
D
K
E
A
I
A
T
S
V
E
L
G
E
D
Site 20
Y220
R
V
V
E
V
N
Q
Y
A
N
E
C
A
E
E
Site 21
S237
P
D
L
P
L
I
Q
S
K
Q
N
E
V
N
A
Site 22
S261
L
Q
R
Q
K
A
L
S
N
A
A
N
L
Q
R
Site 23
T274
Q
R
F
K
R
D
V
T
E
A
I
Q
W
I
K
Site 24
T288
K
E
K
E
P
V
L
T
S
E
D
Y
G
K
D
Site 25
Y292
P
V
L
T
S
E
D
Y
G
K
D
L
V
A
S
Site 26
S299
Y
G
K
D
L
V
A
S
E
G
L
F
H
S
H
Site 27
S305
A
S
E
G
L
F
H
S
H
K
G
L
E
R
N
Site 28
S317
E
R
N
L
A
V
M
S
D
K
V
K
E
L
C
Site 29
S333
K
A
E
K
L
T
L
S
H
P
S
D
A
P
Q
Site 30
S350
E
M
K
E
D
L
V
S
S
W
E
H
I
R
A
Site 31
S361
H
I
R
A
L
A
T
S
R
Y
E
K
L
Q
A
Site 32
Y363
R
A
L
A
T
S
R
Y
E
K
L
Q
A
T
Y
Site 33
Y370
Y
E
K
L
Q
A
T
Y
W
Y
H
R
F
S
S
Site 34
Y372
K
L
Q
A
T
Y
W
Y
H
R
F
S
S
D
F
Site 35
S377
Y
W
Y
H
R
F
S
S
D
F
D
E
L
S
G
Site 36
S383
S
S
D
F
D
E
L
S
G
W
M
N
E
K
T
Site 37
T390
S
G
W
M
N
E
K
T
A
A
I
N
A
D
E
Site 38
S421
Q
H
K
H
E
I
D
S
Y
D
D
R
F
Q
S
Site 39
Y422
H
K
H
E
I
D
S
Y
D
D
R
F
Q
S
A
Site 40
S428
S
Y
D
D
R
F
Q
S
A
D
E
T
G
Q
D
Site 41
T432
R
F
Q
S
A
D
E
T
G
Q
D
L
V
N
A
Site 42
S444
V
N
A
N
H
E
A
S
D
E
V
R
E
K
M
Site 43
S490
R
D
S
E
Q
V
D
S
W
M
S
R
Q
E
A
Site 44
T526
E
D
F
E
E
A
F
T
A
Q
E
E
K
I
I
Site 45
T534
A
Q
E
E
K
I
I
T
V
D
K
T
A
T
K
Site 46
Y548
K
L
I
G
D
D
H
Y
D
S
E
N
I
K
A
Site 47
S550
I
G
D
D
H
Y
D
S
E
N
I
K
A
I
R
Site 48
T573
A
L
R
E
K
A
A
T
R
R
R
L
L
K
E
Site 49
S581
R
R
R
L
L
K
E
S
L
L
L
Q
K
L
Y
Site 50
Y588
S
L
L
L
Q
K
L
Y
E
D
S
D
D
L
K
Site 51
S591
L
Q
K
L
Y
E
D
S
D
D
L
K
N
W
I
Site 52
Y610
K
L
A
D
D
E
D
Y
K
D
I
Q
N
L
K
Site 53
S618
K
D
I
Q
N
L
K
S
R
V
Q
K
Q
Q
V
Site 54
T635
K
E
L
A
V
N
K
T
Q
L
E
N
I
Q
K
Site 55
Y653
E
M
I
E
G
G
H
Y
A
S
D
N
V
T
T
Site 56
S655
I
E
G
G
H
Y
A
S
D
N
V
T
T
R
L
Site 57
T659
H
Y
A
S
D
N
V
T
T
R
L
S
E
V
A
Site 58
S663
D
N
V
T
T
R
L
S
E
V
A
S
L
W
E
Site 59
S667
T
R
L
S
E
V
A
S
L
W
E
E
L
L
E
Site 60
T711
E
D
V
E
W
Q
V
T
S
E
D
Y
G
K
G
Site 61
S734
R
K
H
G
L
L
E
S
A
V
A
A
R
Q
D
Site 62
S761
E
E
I
G
H
P
D
S
K
D
I
R
A
R
Q
Site 63
S770
D
I
R
A
R
Q
E
S
L
V
C
R
F
E
A
Site 64
T784
A
L
K
E
P
L
A
T
R
K
K
K
L
L
D
Site 65
T802
L
Q
L
I
C
R
D
T
E
D
E
E
A
W
I
Site 66
S815
W
I
Q
E
T
E
P
S
A
T
S
T
Y
L
G
Site 67
T817
Q
E
T
E
P
S
A
T
S
T
Y
L
G
K
D
Site 68
T819
T
E
P
S
A
T
S
T
Y
L
G
K
D
L
I
Site 69
S844
V
I
L
E
N
I
A
S
H
E
P
R
I
Q
E
Site 70
T853
E
P
R
I
Q
E
I
T
E
R
G
N
K
M
V
Site 71
S872
F
A
A
E
D
V
A
S
R
V
K
S
L
N
Q
Site 72
S876
D
V
A
S
R
V
K
S
L
N
Q
N
M
E
S
Site 73
S883
S
L
N
Q
N
M
E
S
L
R
A
R
A
A
R
Site 74
Y904
A
N
V
Q
F
Q
Q
Y
L
A
D
L
H
E
A
Site 75
Y927
P
I
V
D
N
T
N
Y
G
A
D
E
E
A
A
Site 76
S954
D
L
N
S
F
G
D
S
M
K
A
L
R
N
Q
Site 77
Y986
E
Q
R
V
M
A
L
Y
D
F
Q
A
R
S
P
Site 78
S992
L
Y
D
F
Q
A
R
S
P
R
E
V
T
M
K
Site 79
T997
A
R
S
P
R
E
V
T
M
K
K
G
D
V
L
Site 80
T1005
M
K
K
G
D
V
L
T
L
L
S
S
I
N
K
Site 81
S1008
G
D
V
L
T
L
L
S
S
I
N
K
D
W
W
Site 82
S1009
D
V
L
T
L
L
S
S
I
N
K
D
W
W
K
Site 83
Y1030
Q
G
I
V
P
A
V
Y
V
R
R
L
A
H
D
Site 84
T1054
R
E
E
P
G
N
I
T
Q
R
Q
E
Q
I
E
Site 85
Y1064
Q
E
Q
I
E
N
Q
Y
R
S
L
L
D
R
A
Site 86
Y1082
R
R
R
L
L
Q
R
Y
N
E
F
L
L
A
Y
Site 87
T1129
E
F
Q
K
D
L
N
T
N
E
P
R
L
R
D
Site 88
S1167
E
L
N
A
R
W
G
S
L
Q
R
L
A
D
E
Site 89
S1181
E
Q
R
Q
L
L
G
S
A
H
A
V
E
V
F
Site 90
T1195
F
H
R
E
A
D
D
T
K
E
Q
I
E
K
K
Site 91
S1207
E
K
K
C
Q
A
L
S
A
A
D
P
G
S
D
Site 92
S1217
D
P
G
S
D
L
F
S
V
Q
A
L
Q
R
R
Site 93
S1250
G
E
T
A
E
R
L
S
E
S
H
P
D
A
T
Site 94
S1252
T
A
E
R
L
S
E
S
H
P
D
A
T
E
D
Site 95
T1257
S
E
S
H
P
D
A
T
E
D
L
Q
R
Q
K
Site 96
S1284
R
T
K
D
R
K
E
S
L
N
E
A
Q
K
F
Site 97
Y1292
L
N
E
A
Q
K
F
Y
L
F
L
S
K
A
R
Site 98
S1296
Q
K
F
Y
L
F
L
S
K
A
R
D
L
Q
N
Site 99
S1306
R
D
L
Q
N
W
I
S
S
I
G
G
M
V
S
Site 100
S1313
S
S
I
G
G
M
V
S
S
Q
E
L
A
E
D
Site 101
S1314
S
I
G
G
M
V
S
S
Q
E
L
A
E
D
L
Site 102
S1358
F
S
A
E
L
I
D
S
G
H
H
A
S
P
E
Site 103
S1363
I
D
S
G
H
H
A
S
P
E
I
E
K
K
L
Site 104
S1417
W
M
V
A
R
E
N
S
L
R
S
D
D
K
S
Site 105
S1420
A
R
E
N
S
L
R
S
D
D
K
S
S
L
D
Site 106
S1424
S
L
R
S
D
D
K
S
S
L
D
S
L
E
A
Site 107
S1425
L
R
S
D
D
K
S
S
L
D
S
L
E
A
L
Site 108
S1428
D
D
K
S
S
L
D
S
L
E
A
L
M
K
K
Site 109
T1451
T
A
Q
E
G
K
I
T
D
L
E
H
F
A
E
Site 110
Y1466
S
L
I
A
D
E
H
Y
A
K
E
E
I
A
T
Site 111
Y1499
E
R
T
K
L
G
D
Y
A
N
L
K
Q
F
Y
Site 112
S1517
E
E
L
E
E
W
I
S
E
M
L
P
T
A
C
Site 113
T1522
W
I
S
E
M
L
P
T
A
C
D
E
S
Y
K
Site 114
Y1528
P
T
A
C
D
E
S
Y
K
D
A
T
N
I
Q
Site 115
Y1538
A
T
N
I
Q
R
K
Y
L
K
H
Q
T
F
A
Site 116
T1543
R
K
Y
L
K
H
Q
T
F
A
H
E
V
D
G
Site 117
S1552
A
H
E
V
D
G
R
S
E
Q
V
H
G
V
I
Site 118
T1614
S
R
Q
Q
R
F
N
T
S
I
R
D
F
E
F
Site 119
S1624
R
D
F
E
F
W
L
S
E
A
E
T
L
L
A
Site 120
T1628
F
W
L
S
E
A
E
T
L
L
A
M
K
D
Q
Site 121
S1641
D
Q
A
R
D
L
A
S
A
G
N
L
L
K
K
Site 122
T1668
D
A
L
K
D
L
N
T
L
A
E
D
L
L
S
Site 123
S1727
Q
D
L
D
D
E
E
S
W
I
E
E
K
L
I
Site 124
S1737
E
E
K
L
I
R
V
S
S
Q
D
Y
G
R
D
Site 125
S1738
E
K
L
I
R
V
S
S
Q
D
Y
G
R
D
L
Site 126
Y1741
I
R
V
S
S
Q
D
Y
G
R
D
L
Q
G
V
Site 127
S1818
R
G
L
K
L
E
E
S
L
E
Y
L
Q
F
M
Site 128
Y1821
K
L
E
E
S
L
E
Y
L
Q
F
M
Q
N
A
Site 129
T1850
V
R
G
D
C
G
D
T
L
A
A
T
Q
S
L
Site 130
S1856
D
T
L
A
A
T
Q
S
L
L
M
K
H
E
A
Site 131
S1894
N
K
V
L
Q
E
E
S
Q
N
K
E
I
S
S
Site 132
S1901
S
Q
N
K
E
I
S
S
K
I
E
A
L
N
E
Site 133
T1910
I
E
A
L
N
E
K
T
P
S
L
A
K
A
I
Site 134
S1912
A
L
N
E
K
T
P
S
L
A
K
A
I
A
A
Site 135
Y1928
K
L
Q
L
E
D
D
Y
A
F
Q
E
F
N
W
Site 136
S1950
W
I
A
D
K
E
T
S
L
K
T
N
G
N
G
Site 137
T1972
T
L
L
A
K
Q
D
T
L
D
A
S
L
Q
S
Site 138
S1976
K
Q
D
T
L
D
A
S
L
Q
S
F
Q
Q
E
Site 139
S1979
T
L
D
A
S
L
Q
S
F
Q
Q
E
R
L
P
Site 140
S2067
E
K
M
E
E
N
L
S
E
P
V
H
C
V
S
Site 141
S2074
S
E
P
V
H
C
V
S
L
N
E
I
R
Q
L
Site 142
S2091
D
H
E
D
F
L
A
S
L
A
R
A
Q
A
D
Site 143
T2123
S
S
P
Y
T
W
L
T
V
E
V
L
E
R
T
Site 144
S2135
E
R
T
W
K
H
L
S
D
I
I
E
E
R
E
Site 145
T2168
E
F
E
Q
N
A
S
T
F
L
Q
W
I
L
E
Site 146
S2184
R
A
Y
F
L
D
G
S
L
L
K
E
T
G
T
Site 147
T2191
S
L
L
K
E
T
G
T
L
E
S
Q
L
E
A
Site 148
T2214
Q
A
M
K
R
Q
L
T
K
I
V
D
L
G
D
Site 149
Y2246
A
Q
Q
W
D
Q
L
Y
Q
L
G
L
R
M
Q
Site 150
S2269
A
K
D
I
K
G
V
S
E
E
T
L
K
E
F
Site 151
Y2280
L
K
E
F
S
T
I
Y
K
H
F
D
E
N
L
Site 152
T2292
E
N
L
T
G
R
L
T
H
K
E
F
R
S
C
Site 153
S2298
L
T
H
K
E
F
R
S
C
L
R
G
L
N
Y
Site 154
Y2305
S
C
L
R
G
L
N
Y
Y
L
P
M
V
E
E
Site 155
Y2306
C
L
R
G
L
N
Y
Y
L
P
M
V
E
E
D
Site 156
Y2333
V
D
P
G
R
K
G
Y
V
S
L
E
D
Y
T
Site 157
S2335
P
G
R
K
G
Y
V
S
L
E
D
Y
T
A
F
Site 158
S2348
A
F
L
I
D
K
E
S
E
N
I
K
S
S
D
Site 159
S2353
K
E
S
E
N
I
K
S
S
D
E
I
E
N
A
Site 160
S2354
E
S
E
N
I
K
S
S
D
E
I
E
N
A
F
Site 161
S2369
Q
A
L
A
E
G
K
S
Y
I
T
K
E
D
M
Site 162
Y2370
A
L
A
E
G
K
S
Y
I
T
K
E
D
M
K
Site 163
T2381
E
D
M
K
Q
A
L
T
P
E
Q
V
S
F
C
Site 164
Y2395
C
A
T
H
M
Q
Q
Y
M
D
P
R
G
R
S
Site 165
S2402
Y
M
D
P
R
G
R
S
H
L
S
G
Y
D
Y
Site 166
S2405
P
R
G
R
S
H
L
S
G
Y
D
Y
V
G
F
Site 167
Y2407
G
R
S
H
L
S
G
Y
D
Y
V
G
F
T
N
Site 168
Y2409
S
H
L
S
G
Y
D
Y
V
G
F
T
N
S
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation