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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGHE
Full Name:
Ig epsilon chain C region
Alias:
Type:
Mass (Da):
47019
Number AA:
428
UniProt ID:
P01854
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
A
S
T
Q
S
P
S
V
F
P
L
T
Site 2
S7
_
A
S
T
Q
S
P
S
V
F
P
L
T
R
C
Site 3
T12
S
P
S
V
F
P
L
T
R
C
C
K
N
I
P
Site 4
S20
R
C
C
K
N
I
P
S
N
A
T
S
V
T
L
Site 5
T45
P
V
M
V
T
W
D
T
G
S
L
N
G
T
T
Site 6
T51
D
T
G
S
L
N
G
T
T
M
T
L
P
A
T
Site 7
T90
F
T
C
R
V
A
H
T
P
S
S
T
D
W
V
Site 8
S93
R
V
A
H
T
P
S
S
T
D
W
V
D
N
K
Site 9
T113
S
R
D
F
T
P
P
T
V
K
I
L
Q
S
S
Site 10
S119
P
T
V
K
I
L
Q
S
S
C
D
G
G
G
H
Site 11
S120
T
V
K
I
L
Q
S
S
C
D
G
G
G
H
F
Site 12
S161
Q
V
M
D
V
D
L
S
T
A
S
T
T
Q
E
Site 13
T162
V
M
D
V
D
L
S
T
A
S
T
T
Q
E
G
Site 14
T165
V
D
L
S
T
A
S
T
T
Q
E
G
E
L
A
Site 15
T174
Q
E
G
E
L
A
S
T
Q
S
E
L
T
L
S
Site 16
S176
G
E
L
A
S
T
Q
S
E
L
T
L
S
Q
K
Site 17
T179
A
S
T
Q
S
E
L
T
L
S
Q
K
H
W
L
Site 18
S181
T
Q
S
E
L
T
L
S
Q
K
H
W
L
S
D
Site 19
Y191
H
W
L
S
D
R
T
Y
T
C
Q
V
T
Y
Q
Site 20
T192
W
L
S
D
R
T
Y
T
C
Q
V
T
Y
Q
G
Site 21
T201
Q
V
T
Y
Q
G
H
T
F
E
D
S
T
K
K
Site 22
S205
Q
G
H
T
F
E
D
S
T
K
K
C
A
D
S
Site 23
S212
S
T
K
K
C
A
D
S
N
P
R
G
V
S
A
Site 24
S218
D
S
N
P
R
G
V
S
A
Y
L
S
R
P
S
Site 25
Y220
N
P
R
G
V
S
A
Y
L
S
R
P
S
P
F
Site 26
S222
R
G
V
S
A
Y
L
S
R
P
S
P
F
D
L
Site 27
S225
S
A
Y
L
S
R
P
S
P
F
D
L
F
I
R
Site 28
T254
S
K
G
T
V
N
L
T
W
S
R
A
S
G
K
Site 29
S256
G
T
V
N
L
T
W
S
R
A
S
G
K
P
V
Site 30
S259
N
L
T
W
S
R
A
S
G
K
P
V
N
H
S
Site 31
S266
S
G
K
P
V
N
H
S
T
R
K
E
E
K
Q
Site 32
T277
E
E
K
Q
R
N
G
T
L
T
V
T
S
T
L
Site 33
T279
K
Q
R
N
G
T
L
T
V
T
S
T
L
P
V
Site 34
S282
N
G
T
L
T
V
T
S
T
L
P
V
G
T
R
Site 35
T283
G
T
L
T
V
T
S
T
L
P
V
G
T
R
D
Site 36
Y297
D
W
I
E
G
E
T
Y
Q
C
R
V
T
H
P
Site 37
T302
E
T
Y
Q
C
R
V
T
H
P
H
L
P
R
A
Site 38
S313
L
P
R
A
L
M
R
S
T
T
K
T
S
G
P
Site 39
T314
P
R
A
L
M
R
S
T
T
K
T
S
G
P
R
Site 40
T315
R
A
L
M
R
S
T
T
K
T
S
G
P
R
A
Site 41
T317
L
M
R
S
T
T
K
T
S
G
P
R
A
A
P
Site 42
T331
P
E
V
Y
A
F
A
T
P
E
W
P
G
S
R
Site 43
S337
A
T
P
E
W
P
G
S
R
D
K
R
T
L
A
Site 44
T342
P
G
S
R
D
K
R
T
L
A
C
L
I
Q
N
Site 45
S372
Q
L
P
D
A
R
H
S
T
T
Q
P
R
K
T
Site 46
T373
L
P
D
A
R
H
S
T
T
Q
P
R
K
T
K
Site 47
T374
P
D
A
R
H
S
T
T
Q
P
R
K
T
K
G
Site 48
T379
S
T
T
Q
P
R
K
T
K
G
S
G
F
F
V
Site 49
S382
Q
P
R
K
T
K
G
S
G
F
F
V
F
S
R
Site 50
S413
R
A
V
H
E
A
A
S
P
S
Q
T
V
Q
R
Site 51
S415
V
H
E
A
A
S
P
S
Q
T
V
Q
R
A
V
Site 52
T417
E
A
A
S
P
S
Q
T
V
Q
R
A
V
S
V
Site 53
S423
Q
T
V
Q
R
A
V
S
V
N
P
G
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation