PhosphoNET

           
Protein Info 
   
Short Name:  POMC
Full Name:  Pro-opiomelanocortin
Alias:  ACTH; Adrenocorticotropic hormone; Adrenocorticotropin; Alpha-melanocyte stimulating hormone; Alpha-MSH; Beta-endorphin; Beta-lipotropin; Beta-LPH; Beta-melanocyte stimulating hormone; Beta-MSH; CLIP; COLI; Corticotropin; Corticotropin-like intermediary peptide; Corticotropin-lipotropin precursor; Gamma-LPH; Gamma-MSH; Lipotropin beta; Lipotropin gamma; LPH; Melanotropin alpha; Melanotropin beta; Melanotropin gamma; Met-enkephalin; MSH; NPP; POC; Potential peptide; Proopiomelanocortin
Type: 
Mass (Da):  29424
Number AA:  267
UniProt ID:  P01189
International Prot ID:  IPI00000160
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005576  GO:0005625   Uniprot OncoNet
Molecular Function:  GO:0005179  GO:0070996   PhosphoSite+ KinaseNET
Biological Process:  GO:0007267  GO:0006091  GO:0007218 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T38SSQCQDLTTESNLLE
Site 2T39SQCQDLTTESNLLEC
Site 3S55RACKPDLSAETPMFP
Site 4T58KPDLSAETPMFPGNG
Site 5T71NGDEQPLTENPRKYV
Site 6Y77LTENPRKYVMGHFRW
Site 7S92DRFGRRNSSSSGSSG
Site 8S93RFGRRNSSSSGSSGA
Site 9S94FGRRNSSSSGSSGAG
Site 10S95GRRNSSSSGSSGAGQ
Site 11S97RNSSSSGSSGAGQKR
Site 12S98NSSSSGSSGAGQKRE
Site 13S108GQKREDVSAGEDCGP
Site 14S125EGGPEPRSDGAKPGP
Site 15S138GPREGKRSYSMEHFR
Site 16Y139PREGKRSYSMEHFRW
Site 17S140REGKRSYSMEHFRWG
Site 18Y160KRRPVKVYPNGAEDE
Site 19S168PNGAEDESAEAFPLE
Site 20T181LEFKRELTGQRLREG
Site 21S230MEHFRWGSPPKDKRY
Site 22Y237SPPKDKRYGGFMTSE
Site 23T242KRYGGFMTSEKSQTP
Site 24S243RYGGFMTSEKSQTPL
Site 25S246GFMTSEKSQTPLVTL
Site 26T248MTSEKSQTPLVTLFK
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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