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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGFB1
Full Name:
Transforming growth factor beta-1
Alias:
Camurati-Engelmann disease; CED; Diaphyseal dysplasia 1, progressive; DPD1; TGFB; TGFbeta; TGF-beta 1; Transforming growth factor, beta 1; Transforming growth factor, beta 1 (Camurati-Engelmann disease)
Type:
Secreted protein
Mass (Da):
44341
Number AA:
390
UniProt ID:
P01137
International Prot ID:
IPI00000075
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005796
GO:0005615
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008083
GO:0016563
GO:0005114
PhosphoSite+
KinaseNET
Biological Process:
GO:0006754
GO:0031575
GO:0007183
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
G
R
P
A
A
G
L
S
T
C
K
T
I
D
M
Site 2
S61
L
S
K
L
R
L
A
S
P
P
S
Q
G
E
V
Site 3
S64
L
R
L
A
S
P
P
S
Q
G
E
V
P
P
G
Site 4
Y81
P
E
A
V
L
A
L
Y
N
S
T
R
D
R
V
Site 5
S92
R
D
R
V
A
G
E
S
A
E
P
E
P
E
P
Site 6
Y103
E
P
E
P
E
A
D
Y
Y
A
K
E
V
T
R
Site 7
Y104
P
E
P
E
A
D
Y
Y
A
K
E
V
T
R
V
Site 8
Y132
K
Q
S
T
H
S
I
Y
M
F
F
N
T
S
E
Site 9
Y171
V
E
Q
H
V
E
L
Y
Q
K
Y
S
N
N
S
Site 10
Y174
H
V
E
L
Y
Q
K
Y
S
N
N
S
W
R
Y
Site 11
Y181
Y
S
N
N
S
W
R
Y
L
S
N
R
L
L
A
Site 12
S183
N
N
S
W
R
Y
L
S
N
R
L
L
A
P
S
Site 13
S190
S
N
R
L
L
A
P
S
D
S
P
E
W
L
S
Site 14
S192
R
L
L
A
P
S
D
S
P
E
W
L
S
F
D
Site 15
S197
S
D
S
P
E
W
L
S
F
D
V
T
G
V
V
Site 16
S209
G
V
V
R
Q
W
L
S
R
G
G
E
I
E
G
Site 17
S220
E
I
E
G
F
R
L
S
A
H
C
S
C
D
S
Site 18
S224
F
R
L
S
A
H
C
S
C
D
S
R
D
N
T
Site 19
S227
S
A
H
C
S
C
D
S
R
D
N
T
L
Q
V
Site 20
T231
S
C
D
S
R
D
N
T
L
Q
V
D
I
N
G
Site 21
T241
V
D
I
N
G
F
T
T
G
R
R
G
D
L
A
Site 22
T249
G
R
R
G
D
L
A
T
I
H
G
M
N
R
P
Site 23
S273
E
R
A
Q
H
L
Q
S
S
R
H
R
R
A
L
Site 24
S274
R
A
Q
H
L
Q
S
S
R
H
R
R
A
L
D
Site 25
T282
R
H
R
R
A
L
D
T
N
Y
C
F
S
S
T
Site 26
Y284
R
R
A
L
D
T
N
Y
C
F
S
S
T
E
K
Site 27
Y299
N
C
C
V
R
Q
L
Y
I
D
F
R
K
D
L
Site 28
Y317
W
I
H
E
P
K
G
Y
H
A
N
F
C
L
G
Site 29
T334
P
Y
I
W
S
L
D
T
Q
Y
S
K
V
L
A
Site 30
S337
W
S
L
D
T
Q
Y
S
K
V
L
A
L
Y
N
Site 31
Y343
Y
S
K
V
L
A
L
Y
N
Q
H
N
P
G
A
Site 32
Y368
L
E
P
L
P
I
V
Y
Y
V
G
R
K
P
K
Site 33
Y369
E
P
L
P
I
V
Y
Y
V
G
R
K
P
K
V
Site 34
S380
K
P
K
V
E
Q
L
S
N
M
I
V
R
S
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation