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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
F12
Full Name:
Coagulation factor XII
Alias:
Hageman factor
Type:
Mass (Da):
67818
Number AA:
615
UniProt ID:
P00748
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
V
S
L
E
S
T
L
S
I
P
P
W
E
A
P
Site 2
Y31
E
A
P
K
E
H
K
Y
K
A
E
E
H
T
V
Site 3
T41
E
E
H
T
V
V
L
T
V
T
G
E
P
C
H
Site 4
Y53
P
C
H
F
P
F
Q
Y
H
R
Q
L
Y
H
K
Site 5
Y58
F
Q
Y
H
R
Q
L
Y
H
K
C
T
H
K
G
Site 6
T62
R
Q
L
Y
H
K
C
T
H
K
G
R
P
G
P
Site 7
Y87
D
Q
D
Q
R
W
G
Y
C
L
E
P
K
K
V
Site 8
S102
K
D
H
C
S
K
H
S
P
C
Q
K
G
G
T
Site 9
T109
S
P
C
Q
K
G
G
T
C
V
N
M
P
S
G
Site 10
S175
A
H
C
Q
R
L
A
S
Q
A
C
R
T
N
P
Site 11
T213
G
P
F
C
D
V
D
T
K
A
S
C
Y
D
G
Site 12
Y218
V
D
T
K
A
S
C
Y
D
G
R
G
L
S
Y
Site 13
S224
C
Y
D
G
R
G
L
S
Y
R
G
L
A
R
T
Site 14
T231
S
Y
R
G
L
A
R
T
T
L
S
G
A
P
C
Site 15
T232
Y
R
G
L
A
R
T
T
L
S
G
A
P
C
Q
Site 16
S234
G
L
A
R
T
T
L
S
G
A
P
C
Q
P
W
Site 17
Y247
P
W
A
S
E
A
T
Y
R
N
V
T
A
E
Q
Site 18
T251
E
A
T
Y
R
N
V
T
A
E
Q
A
R
N
W
Site 19
S286
V
L
N
R
D
R
L
S
W
E
Y
C
D
L
A
Site 20
Y289
R
D
R
L
S
W
E
Y
C
D
L
A
Q
C
Q
Site 21
T297
C
D
L
A
Q
C
Q
T
P
T
Q
A
A
P
P
Site 22
T305
P
T
Q
A
A
P
P
T
P
V
S
P
R
L
H
Site 23
T328
A
P
P
K
P
Q
P
T
T
R
T
P
P
Q
S
Site 24
T329
P
P
K
P
Q
P
T
T
R
T
P
P
Q
S
Q
Site 25
T331
K
P
Q
P
T
T
R
T
P
P
Q
S
Q
T
P
Site 26
S335
T
T
R
T
P
P
Q
S
Q
T
P
G
A
L
P
Site 27
T337
R
T
P
P
Q
S
Q
T
P
G
A
L
P
A
K
Site 28
S350
A
K
R
E
Q
P
P
S
L
T
R
N
G
P
L
Site 29
T352
R
E
Q
P
P
S
L
T
R
N
G
P
L
S
C
Site 30
S358
L
T
R
N
G
P
L
S
C
G
Q
R
L
R
K
Site 31
S366
C
G
Q
R
L
R
K
S
L
S
S
M
T
R
V
Site 32
S368
Q
R
L
R
K
S
L
S
S
M
T
R
V
V
G
Site 33
S369
R
L
R
K
S
L
S
S
M
T
R
V
V
G
G
Site 34
T371
R
K
S
L
S
S
M
T
R
V
V
G
G
L
V
Site 35
T424
R
P
A
P
E
D
L
T
V
V
L
G
Q
E
R
Site 36
S435
G
Q
E
R
R
N
H
S
C
E
P
C
Q
T
L
Site 37
T441
H
S
C
E
P
C
Q
T
L
A
V
R
S
Y
R
Site 38
S446
C
Q
T
L
A
V
R
S
Y
R
L
H
E
A
F
Site 39
Y447
Q
T
L
A
V
R
S
Y
R
L
H
E
A
F
S
Site 40
S454
Y
R
L
H
E
A
F
S
P
V
S
Y
Q
H
D
Site 41
S457
H
E
A
F
S
P
V
S
Y
Q
H
D
L
A
L
Site 42
S474
L
Q
E
D
A
D
G
S
C
A
L
L
S
P
Y
Site 43
S489
V
Q
P
V
C
L
P
S
G
A
A
R
P
S
E
Site 44
S495
P
S
G
A
A
R
P
S
E
T
T
L
C
Q
V
Site 45
T498
A
A
R
P
S
E
T
T
L
C
Q
V
A
G
W
Site 46
S517
E
G
A
E
E
Y
A
S
F
L
Q
E
A
Q
V
Site 47
S528
E
A
Q
V
P
F
L
S
L
E
R
C
S
A
P
Site 48
S533
F
L
S
L
E
R
C
S
A
P
D
V
H
G
S
Site 49
T579
Q
A
A
E
R
R
L
T
L
Q
G
I
I
S
W
Site 50
S588
Q
G
I
I
S
W
G
S
G
C
G
D
R
N
K
Site 51
Y605
V
Y
T
D
V
A
Y
Y
L
A
W
I
R
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation