KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
F2
Full Name:
Prothrombin
Alias:
Coagulation factor II
Type:
Mass (Da):
70019
Number AA:
622
UniProt ID:
P00734
International Prot ID:
IPI00019568
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005576
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0003809
GO:0003824
GO:0004175
PhosphoSite+
KinaseNET
Biological Process:
GO:0000060
GO:0001775
GO:0002526
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
Q
R
V
R
R
A
N
T
F
L
E
E
V
R
K
Site 2
S66
E
C
V
E
E
T
C
S
Y
E
E
A
F
E
A
Site 3
Y67
C
V
E
E
T
C
S
Y
E
E
A
F
E
A
L
Site 4
S76
E
A
F
E
A
L
E
S
S
T
A
T
D
V
F
Site 5
T80
A
L
E
S
S
T
A
T
D
V
F
W
A
K
Y
Site 6
Y87
T
D
V
F
W
A
K
Y
T
A
C
E
T
A
R
Site 7
T95
T
A
C
E
T
A
R
T
P
R
D
K
L
A
A
Site 8
Y136
C
Q
L
W
R
S
R
Y
P
H
K
P
E
I
N
Site 9
T145
H
K
P
E
I
N
S
T
T
H
P
G
A
D
L
Site 10
Y170
S
T
T
G
P
W
C
Y
T
T
D
P
T
V
R
Site 11
T171
T
T
G
P
W
C
Y
T
T
D
P
T
V
R
R
Site 12
S182
T
V
R
R
Q
E
C
S
I
P
V
C
G
Q
D
Site 13
T192
V
C
G
Q
D
Q
V
T
V
A
M
T
P
R
S
Site 14
T196
D
Q
V
T
V
A
M
T
P
R
S
E
G
S
S
Site 15
S199
T
V
A
M
T
P
R
S
E
G
S
S
V
N
L
Site 16
S202
M
T
P
R
S
E
G
S
S
V
N
L
S
P
P
Site 17
S203
T
P
R
S
E
G
S
S
V
N
L
S
P
P
L
Site 18
S207
E
G
S
S
V
N
L
S
P
P
L
E
Q
C
V
Site 19
Y221
V
P
D
R
G
Q
Q
Y
Q
G
R
L
A
V
T
Site 20
T228
Y
Q
G
R
L
A
V
T
T
H
G
L
P
C
L
Site 21
S239
L
P
C
L
A
W
A
S
A
Q
A
K
A
L
S
Site 22
S246
S
A
Q
A
K
A
L
S
K
H
Q
D
F
N
S
Site 23
S253
S
K
H
Q
D
F
N
S
A
V
Q
L
V
E
N
Site 24
Y275
D
E
E
G
V
W
C
Y
V
A
G
K
P
G
D
Site 25
Y285
G
K
P
G
D
F
G
Y
C
D
L
N
Y
C
E
Site 26
Y290
F
G
Y
C
D
L
N
Y
C
E
E
A
V
E
E
Site 27
S307
G
D
G
L
D
E
D
S
D
R
A
I
E
G
R
Site 28
T317
A
I
E
G
R
T
A
T
S
E
Y
Q
T
F
F
Site 29
Y320
G
R
T
A
T
S
E
Y
Q
T
F
F
N
P
R
Site 30
T322
T
A
T
S
E
Y
Q
T
F
F
N
P
R
T
F
Site 31
T328
Q
T
F
F
N
P
R
T
F
G
S
G
E
A
D
Site 32
S331
F
N
P
R
T
F
G
S
G
E
A
D
C
G
L
Site 33
S346
R
P
L
F
E
K
K
S
L
E
D
K
T
E
R
Site 34
T351
K
K
S
L
E
D
K
T
E
R
E
L
L
E
S
Site 35
S358
T
E
R
E
L
L
E
S
Y
I
D
G
R
I
V
Site 36
S368
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
Site 37
S385
Q
V
M
L
F
R
K
S
P
Q
E
L
L
C
G
Site 38
S430
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
Site 39
Y434
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
Site 40
Y448
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
Site 41
Y453
K
I
Y
I
H
P
R
Y
N
W
R
E
N
L
D
Site 42
S491
P
D
R
E
T
A
A
S
L
L
Q
A
G
Y
K
Site 43
Y497
A
S
L
L
Q
A
G
Y
K
G
R
V
T
G
W
Site 44
T502
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
Site 45
T512
G
N
L
K
E
T
W
T
A
N
V
G
K
G
Q
Site 46
S539
E
R
P
V
C
K
D
S
T
R
I
R
I
T
D
Site 47
T540
R
P
V
C
K
D
S
T
R
I
R
I
T
D
N
Site 48
Y553
D
N
M
F
C
A
G
Y
K
P
D
E
G
K
R
Site 49
Y600
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
Site 50
Y603
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
Site 51
T604
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation