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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
F8
Full Name:
Coagulation factor VIII
Alias:
AHF; Antihemophilic; Antihemophilic factor; Coagulation factor VIII, procoagulant component; DXS1253E; F8B; F8C; FA8; Factor; Factor VIII B chain; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIIIa light chain; Factor VIIIF8B; FVIII; HEMA; Hemophilia A; Procoagulant component
Type:
Secreted protein
Mass (Da):
267009
Number AA:
2351
UniProt ID:
P00451
International Prot ID:
IPI00017603
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005886
GO:0031093
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005507
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0006953
GO:0007596
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
L
R
F
C
F
S
A
T
R
R
Y
Y
L
G
A
Site 2
Y25
F
S
A
T
R
R
Y
Y
L
G
A
V
E
L
S
Site 3
Y35
A
V
E
L
S
W
D
Y
M
Q
S
D
L
G
E
Site 4
S38
L
S
W
D
Y
M
Q
S
D
L
G
E
L
P
V
Site 5
S56
F
P
P
R
V
P
K
S
F
P
F
N
T
S
V
Site 6
S62
K
S
F
P
F
N
T
S
V
V
Y
K
K
T
L
Site 7
S116
N
M
A
S
H
P
V
S
L
H
A
V
G
V
S
Site 8
Y133
K
A
S
E
G
A
E
Y
D
D
Q
T
S
Q
R
Site 9
T137
G
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
Site 10
S138
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
D
Site 11
Y155
F
P
G
G
S
H
T
Y
V
W
Q
V
L
K
E
Site 12
S168
K
E
N
G
P
M
A
S
D
P
L
C
L
T
Y
Site 13
Y175
S
D
P
L
C
L
T
Y
S
Y
L
S
H
V
D
Site 14
S202
L
L
V
C
R
E
G
S
L
A
K
E
K
T
Q
Site 15
T208
G
S
L
A
K
E
K
T
Q
T
L
H
K
F
I
Site 16
S226
A
V
F
D
E
G
K
S
W
H
S
E
T
K
N
Site 17
S234
W
H
S
E
T
K
N
S
L
M
Q
D
R
D
A
Site 18
S243
M
Q
D
R
D
A
A
S
A
R
A
W
P
K
M
Site 19
T252
R
A
W
P
K
M
H
T
V
N
G
Y
V
N
R
Site 20
Y256
K
M
H
T
V
N
G
Y
V
N
R
S
L
P
G
Site 21
S287
G
T
T
P
E
V
H
S
I
F
L
E
G
H
T
Site 22
T294
S
I
F
L
E
G
H
T
F
L
V
R
N
H
R
Site 23
S304
V
R
N
H
R
Q
A
S
L
E
I
S
P
I
T
Site 24
Y342
Q
H
D
G
M
E
A
Y
V
K
V
D
S
C
P
Site 25
S347
E
A
Y
V
K
V
D
S
C
P
E
E
P
Q
L
Site 26
Y365
N
N
E
E
A
E
D
Y
D
D
D
L
T
D
S
Site 27
T370
E
D
Y
D
D
D
L
T
D
S
E
M
D
V
V
Site 28
S372
Y
D
D
D
L
T
D
S
E
M
D
V
V
R
F
Site 29
S384
V
R
F
D
D
D
N
S
P
S
F
I
Q
I
R
Site 30
S386
F
D
D
D
N
S
P
S
F
I
Q
I
R
S
V
Site 31
S392
P
S
F
I
Q
I
R
S
V
A
K
K
H
P
K
Site 32
T400
V
A
K
K
H
P
K
T
W
V
H
Y
I
A
A
Site 33
Y414
A
E
E
E
D
W
D
Y
A
P
L
V
L
A
P
Site 34
S425
V
L
A
P
D
D
R
S
Y
K
S
Q
Y
L
N
Site 35
Y426
L
A
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
Site 36
S428
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Site 37
Y430
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Q
R
Site 38
Y442
P
Q
R
I
G
R
K
Y
K
K
V
R
F
M
A
Site 39
T451
K
V
R
F
M
A
Y
T
D
E
T
F
K
T
R
Site 40
T454
F
M
A
Y
T
D
E
T
F
K
T
R
E
A
I
Site 41
T457
Y
T
D
E
T
F
K
T
R
E
A
I
Q
H
E
Site 42
Y492
K
N
Q
A
S
R
P
Y
N
I
Y
P
H
G
I
Site 43
Y495
A
S
R
P
Y
N
I
Y
P
H
G
I
T
D
V
Site 44
T500
N
I
Y
P
H
G
I
T
D
V
R
P
L
Y
S
Site 45
Y506
I
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
Site 46
S507
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
V
Site 47
Y530
L
P
G
E
I
F
K
Y
K
W
T
V
T
V
E
Site 48
T533
E
I
F
K
Y
K
W
T
V
T
V
E
D
G
P
Site 49
T535
F
K
Y
K
W
T
V
T
V
E
D
G
P
T
K
Site 50
T541
V
T
V
E
D
G
P
T
K
S
D
P
R
C
L
Site 51
S543
V
E
D
G
P
T
K
S
D
P
R
C
L
T
R
Site 52
T549
K
S
D
P
R
C
L
T
R
Y
Y
S
S
F
V
Site 53
Y551
D
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
Site 54
Y552
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
Site 55
S553
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
R
Site 56
Y574
I
G
P
L
L
I
C
Y
K
E
S
V
D
Q
R
Site 57
S587
Q
R
G
N
Q
I
M
S
D
K
R
N
V
I
L
Site 58
S596
K
R
N
V
I
L
F
S
V
F
D
E
N
R
S
Site 59
Y605
F
D
E
N
R
S
W
Y
L
T
E
N
I
Q
R
Site 60
T607
E
N
R
S
W
Y
L
T
E
N
I
Q
R
F
L
Site 61
Y639
I
M
H
S
I
N
G
Y
V
F
D
S
L
Q
L
Site 62
Y683
T
F
K
H
K
M
V
Y
E
D
T
L
T
L
F
Site 63
T686
H
K
M
V
Y
E
D
T
L
T
L
F
P
F
S
Site 64
S700
S
G
E
T
V
F
M
S
M
E
N
P
G
L
W
Site 65
T722
D
F
R
N
R
G
M
T
A
L
L
K
V
S
S
Site 66
S729
T
A
L
L
K
V
S
S
C
D
K
N
T
G
D
Site 67
Y737
C
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
Site 68
Y738
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
I
Site 69
S741
T
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
Site 70
Y742
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
L
Site 71
S746
E
D
S
Y
E
D
I
S
A
Y
L
L
S
K
N
Site 72
Y748
S
Y
E
D
I
S
A
Y
L
L
S
K
N
N
A
Site 73
S760
N
N
A
I
E
P
R
S
F
S
Q
N
S
R
H
Site 74
S762
A
I
E
P
R
S
F
S
Q
N
S
R
H
P
S
Site 75
S765
P
R
S
F
S
Q
N
S
R
H
P
S
T
R
Q
Site 76
S769
S
Q
N
S
R
H
P
S
T
R
Q
K
Q
F
N
Site 77
T818
M
L
L
R
Q
S
P
T
P
H
G
L
S
L
S
Site 78
S823
S
P
T
P
H
G
L
S
L
S
D
L
Q
E
A
Site 79
S825
T
P
H
G
L
S
L
S
D
L
Q
E
A
K
Y
Site 80
Y832
S
D
L
Q
E
A
K
Y
E
T
F
S
D
D
P
Site 81
T834
L
Q
E
A
K
Y
E
T
F
S
D
D
P
S
P
Site 82
S836
E
A
K
Y
E
T
F
S
D
D
P
S
P
G
A
Site 83
S840
E
T
F
S
D
D
P
S
P
G
A
I
D
S
N
Site 84
S846
P
S
P
G
A
I
D
S
N
N
S
L
S
E
M
Site 85
S849
G
A
I
D
S
N
N
S
L
S
E
M
T
H
F
Site 86
S851
I
D
S
N
N
S
L
S
E
M
T
H
F
R
P
Site 87
T869
H
S
G
D
M
V
F
T
P
E
S
G
L
Q
L
Site 88
S872
D
M
V
F
T
P
E
S
G
L
Q
L
R
L
N
Site 89
T884
R
L
N
E
K
L
G
T
T
A
A
T
E
L
K
Site 90
S898
K
K
L
D
F
K
V
S
S
T
S
N
N
L
I
Site 91
S899
K
L
D
F
K
V
S
S
T
S
N
N
L
I
S
Site 92
S901
D
F
K
V
S
S
T
S
N
N
L
I
S
T
I
Site 93
S906
S
T
S
N
N
L
I
S
T
I
P
S
D
N
L
Site 94
T917
S
D
N
L
A
A
G
T
D
N
T
S
S
L
G
Site 95
T920
L
A
A
G
T
D
N
T
S
S
L
G
P
P
S
Site 96
S921
A
A
G
T
D
N
T
S
S
L
G
P
P
S
M
Site 97
S922
A
G
T
D
N
T
S
S
L
G
P
P
S
M
P
Site 98
S927
T
S
S
L
G
P
P
S
M
P
V
H
Y
D
S
Site 99
Y932
P
P
S
M
P
V
H
Y
D
S
Q
L
D
T
T
Site 100
S934
S
M
P
V
H
Y
D
S
Q
L
D
T
T
L
F
Site 101
T938
H
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
Site 102
T939
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
S
Site 103
S945
T
T
L
F
G
K
K
S
S
P
L
T
E
S
G
Site 104
S946
T
L
F
G
K
K
S
S
P
L
T
E
S
G
G
Site 105
T949
G
K
K
S
S
P
L
T
E
S
G
G
P
L
S
Site 106
S951
K
S
S
P
L
T
E
S
G
G
P
L
S
L
S
Site 107
S956
T
E
S
G
G
P
L
S
L
S
E
E
N
N
D
Site 108
S958
S
G
G
P
L
S
L
S
E
E
N
N
D
S
K
Site 109
S964
L
S
E
E
N
N
D
S
K
L
L
E
S
G
L
Site 110
S974
L
E
S
G
L
M
N
S
Q
E
S
S
W
G
K
Site 111
S978
L
M
N
S
Q
E
S
S
W
G
K
N
V
S
S
Site 112
S984
S
S
W
G
K
N
V
S
S
T
E
S
G
R
L
Site 113
S985
S
W
G
K
N
V
S
S
T
E
S
G
R
L
F
Site 114
T986
W
G
K
N
V
S
S
T
E
S
G
R
L
F
K
Site 115
S988
K
N
V
S
S
T
E
S
G
R
L
F
K
G
K
Site 116
T1019
V
S
I
S
L
L
K
T
N
K
T
S
N
N
S
Site 117
T1022
S
L
L
K
T
N
K
T
S
N
N
S
A
T
N
Site 118
S1023
L
L
K
T
N
K
T
S
N
N
S
A
T
N
R
Site 119
S1026
T
N
K
T
S
N
N
S
A
T
N
R
K
T
H
Site 120
T1028
K
T
S
N
N
S
A
T
N
R
K
T
H
I
D
Site 121
T1032
N
S
A
T
N
R
K
T
H
I
D
G
P
S
L
Site 122
S1038
K
T
H
I
D
G
P
S
L
L
I
E
N
S
P
Site 123
S1044
P
S
L
L
I
E
N
S
P
S
V
W
Q
N
I
Site 124
S1054
V
W
Q
N
I
L
E
S
D
T
E
F
K
K
V
Site 125
T1062
D
T
E
F
K
K
V
T
P
L
I
H
D
R
M
Site 126
S1084
A
L
R
L
N
H
M
S
N
K
T
T
S
S
K
Site 127
T1088
N
H
M
S
N
K
T
T
S
S
K
N
M
E
M
Site 128
S1124
K
M
L
F
L
P
E
S
A
R
W
I
Q
R
T
Site 129
T1131
S
A
R
W
I
Q
R
T
H
G
K
N
S
L
N
Site 130
S1136
Q
R
T
H
G
K
N
S
L
N
S
G
Q
G
P
Site 131
S1139
H
G
K
N
S
L
N
S
G
Q
G
P
S
P
K
Site 132
S1144
L
N
S
G
Q
G
P
S
P
K
Q
L
V
S
L
Site 133
S1150
P
S
P
K
Q
L
V
S
L
G
P
E
K
S
V
Site 134
S1156
V
S
L
G
P
E
K
S
V
E
G
Q
N
F
L
Site 135
S1164
V
E
G
Q
N
F
L
S
E
K
N
K
V
V
V
Site 136
S1190
K
E
M
V
F
P
S
S
R
N
L
F
L
T
N
Site 137
T1196
S
S
R
N
L
F
L
T
N
L
D
N
L
H
E
Site 138
T1222
E
E
I
E
K
K
E
T
L
I
Q
E
N
V
V
Site 139
S1250
M
K
N
L
F
L
L
S
T
R
Q
N
V
E
G
Site 140
Y1263
E
G
S
Y
D
G
A
Y
A
P
V
L
Q
D
F
Site 141
S1272
P
V
L
Q
D
F
R
S
L
N
D
S
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N
R
Site 142
S1276
D
F
R
S
L
N
D
S
T
N
R
T
K
K
H
Site 143
T1277
F
R
S
L
N
D
S
T
N
R
T
K
K
H
T
Site 144
T1280
L
N
D
S
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N
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T
K
K
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T
A
H
F
Site 145
T1284
T
N
R
T
K
K
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T
A
H
F
S
K
K
G
Site 146
S1288
K
K
H
T
A
H
F
S
K
K
G
E
E
E
N
Site 147
Y1310
T
K
Q
I
V
E
K
Y
A
C
T
T
R
I
S
Site 148
T1313
I
V
E
K
Y
A
C
T
T
R
I
S
P
N
T
Site 149
S1317
Y
A
C
T
T
R
I
S
P
N
T
S
Q
Q
N
Site 150
S1321
T
R
I
S
P
N
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S
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Q
N
F
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Q
Site 151
T1327
T
S
Q
Q
N
F
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T
Q
R
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K
R
A
L
Site 152
S1330
Q
N
F
V
T
Q
R
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R
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L
K
Q
F
Site 153
T1355
K
R
I
I
V
D
D
T
S
T
Q
W
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K
N
Site 154
T1357
I
I
V
D
D
T
S
T
Q
W
S
K
N
M
K
Site 155
T1367
S
K
N
M
K
H
L
T
P
S
T
L
T
Q
I
Site 156
T1370
M
K
H
L
T
P
S
T
L
T
Q
I
D
Y
N
Site 157
Y1376
S
T
L
T
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Y
N
E
K
E
K
G
A
Site 158
T1385
E
K
E
K
G
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L
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C
Site 159
S1387
E
K
G
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Site 160
S1390
A
I
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Site 161
T1394
S
P
L
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S
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P
Q
Site 162
S1396
L
S
D
C
L
T
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H
S
I
P
Q
A
N
Site 163
S1398
D
C
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A
N
R
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Site 164
S1405
S
I
P
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A
N
R
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P
I
A
K
V
Site 165
S1413
P
L
P
I
A
K
V
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S
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P
S
I
R
P
Site 166
T1424
S
I
R
P
I
Y
L
T
R
V
L
F
Q
D
N
Site 167
S1432
R
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Site 168
S1433
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Y
Site 169
S1439
S
S
H
L
P
A
A
S
Y
R
K
K
D
S
G
Site 170
Y1440
S
H
L
P
A
A
S
Y
R
K
K
D
S
G
V
Site 171
S1445
A
S
Y
R
K
K
D
S
G
V
Q
E
S
S
H
Site 172
S1480
G
D
Q
R
E
V
G
S
L
G
T
S
A
T
N
Site 173
S1484
E
V
G
S
L
G
T
S
A
T
N
S
V
T
Y
Site 174
T1486
G
S
L
G
T
S
A
T
N
S
V
T
Y
K
K
Site 175
S1488
L
G
T
S
A
T
N
S
V
T
Y
K
K
V
E
Site 176
T1497
T
Y
K
K
V
E
N
T
V
L
P
K
P
D
L
Site 177
T1507
P
K
P
D
L
P
K
T
S
G
K
V
E
L
L
Site 178
S1508
K
P
D
L
P
K
T
S
G
K
V
E
L
L
P
Site 179
T1529
K
D
L
F
P
T
E
T
S
N
G
S
P
G
H
Site 180
S1530
D
L
F
P
T
E
T
S
N
G
S
P
G
H
L
Site 181
S1533
P
T
E
T
S
N
G
S
P
G
H
L
D
L
V
Site 182
S1543
H
L
D
L
V
E
G
S
L
L
Q
G
T
E
G
Site 183
T1570
V
P
F
L
R
V
A
T
E
S
S
A
K
T
P
Site 184
S1572
F
L
R
V
A
T
E
S
S
A
K
T
P
S
K
Site 185
T1576
A
T
E
S
S
A
K
T
P
S
K
L
L
D
P
Site 186
S1578
E
S
S
A
K
T
P
S
K
L
L
D
P
L
A
Site 187
Y1590
P
L
A
W
D
N
H
Y
G
T
Q
I
P
K
E
Site 188
S1601
I
P
K
E
E
W
K
S
Q
E
K
S
P
E
K
Site 189
S1605
E
W
K
S
Q
E
K
S
P
E
K
T
A
F
K
Site 190
T1609
Q
E
K
S
P
E
K
T
A
F
K
K
K
D
T
Site 191
S1619
K
K
K
D
T
I
L
S
L
N
A
C
E
S
N
Site 192
T1644
N
K
P
E
I
E
V
T
W
A
K
Q
G
R
T
Site 193
T1651
T
W
A
K
Q
G
R
T
E
R
L
C
S
Q
N
Site 194
S1656
G
R
T
E
R
L
C
S
Q
N
P
P
V
L
K
Site 195
T1670
K
R
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Site 196
T1672
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
Site 197
T1673
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
E
Site 198
S1676
I
T
R
T
T
L
Q
S
D
Q
E
E
I
D
Y
Site 199
Y1683
S
D
Q
E
E
I
D
Y
D
D
T
I
S
V
E
Site 200
T1686
E
E
I
D
Y
D
D
T
I
S
V
E
M
K
K
Site 201
S1688
I
D
Y
D
D
T
I
S
V
E
M
K
K
E
D
Site 202
Y1699
K
K
E
D
F
D
I
Y
D
E
D
E
N
Q
S
Site 203
S1706
Y
D
E
D
E
N
Q
S
P
R
S
F
Q
K
K
Site 204
S1709
D
E
N
Q
S
P
R
S
F
Q
K
K
T
R
H
Site 205
Y1717
F
Q
K
K
T
R
H
Y
F
I
A
A
V
E
R
Site 206
Y1728
A
V
E
R
L
W
D
Y
G
M
S
S
S
P
H
Site 207
S1731
R
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
Site 208
S1732
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
Site 209
S1733
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
R
Site 210
S1743
V
L
R
N
R
A
Q
S
G
S
V
P
Q
F
K
Site 211
S1745
R
N
R
A
Q
S
G
S
V
P
Q
F
K
K
V
Site 212
S1761
F
Q
E
F
T
D
G
S
F
T
Q
P
L
Y
R
Site 213
Y1767
G
S
F
T
Q
P
L
Y
R
G
E
L
N
E
H
Site 214
Y1781
H
L
G
L
L
G
P
Y
I
R
A
E
V
E
D
Site 215
T1793
V
E
D
N
I
M
V
T
F
R
N
Q
A
S
R
Site 216
S1799
V
T
F
R
N
Q
A
S
R
P
Y
S
F
Y
S
Site 217
Y1802
R
N
Q
A
S
R
P
Y
S
F
Y
S
S
L
I
Site 218
S1803
N
Q
A
S
R
P
Y
S
F
Y
S
S
L
I
S
Site 219
Y1805
A
S
R
P
Y
S
F
Y
S
S
L
I
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Y
E
Site 220
S1806
S
R
P
Y
S
F
Y
S
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I
S
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E
E
Site 221
S1807
R
P
Y
S
F
Y
S
S
L
I
S
Y
E
E
D
Site 222
S1810
S
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
Site 223
Y1811
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
G
Site 224
Y1834
K
P
N
E
T
K
T
Y
F
W
K
V
Q
H
H
Site 225
Y1856
F
D
C
K
A
W
A
Y
F
S
D
V
D
L
E
Site 226
T1881
L
L
V
C
H
T
N
T
L
N
P
A
H
G
R
Site 227
T1891
P
A
H
G
R
Q
V
T
V
Q
E
F
A
L
F
Site 228
Y1909
F
D
E
T
K
S
W
Y
F
T
E
N
M
E
R
Site 229
T1930
N
I
Q
M
E
D
P
T
F
K
E
N
Y
R
F
Site 230
Y1943
R
F
H
A
I
N
G
Y
I
M
D
T
L
P
G
Site 231
T1947
I
N
G
Y
I
M
D
T
L
P
G
L
V
M
A
Site 232
Y1962
Q
D
Q
R
I
R
W
Y
L
L
S
M
G
S
N
Site 233
T1983
H
F
S
G
H
V
F
T
V
R
K
K
E
E
Y
Site 234
Y1990
T
V
R
K
K
E
E
Y
K
M
A
L
Y
N
L
Site 235
Y1995
E
E
Y
K
M
A
L
Y
N
L
Y
P
G
V
F
Site 236
S2010
E
T
V
E
M
L
P
S
K
A
G
I
W
R
V
Site 237
T2042
V
Y
S
N
K
C
Q
T
P
L
G
M
A
S
G
Site 238
T2057
H
I
R
D
F
Q
I
T
A
S
G
Q
Y
G
Q
Site 239
Y2074
P
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
Site 240
S2075
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
S
Site 241
S2077
A
R
L
H
Y
S
G
S
I
N
A
W
S
T
K
Site 242
S2082
S
G
S
I
N
A
W
S
T
K
E
P
F
S
W
Site 243
T2083
G
S
I
N
A
W
S
T
K
E
P
F
S
W
I
Site 244
S2088
W
S
T
K
E
P
F
S
W
I
K
V
D
L
L
Site 245
S2113
Q
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
Site 246
S2114
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
I
Site 247
Y2124
I
S
Q
F
I
I
M
Y
S
L
D
G
K
K
W
Site 248
T2133
L
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
Site 249
Y2134
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
T
Site 250
T2141
Y
R
G
N
S
T
G
T
L
M
V
F
F
G
N
Site 251
Y2167
N
P
P
I
I
A
R
Y
I
R
L
H
P
T
H
Site 252
T2173
R
Y
I
R
L
H
P
T
H
Y
S
I
R
S
T
Site 253
Y2175
I
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
Site 254
S2176
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
M
Site 255
T2180
T
H
Y
S
I
R
S
T
L
R
M
E
L
M
G
Site 256
S2194
G
C
D
L
N
S
C
S
M
P
L
G
M
E
S
Site 257
S2201
S
M
P
L
G
M
E
S
K
A
I
S
D
A
Q
Site 258
S2205
G
M
E
S
K
A
I
S
D
A
Q
I
T
A
S
Site 259
S2212
S
D
A
Q
I
T
A
S
S
Y
F
T
N
M
F
Site 260
S2223
T
N
M
F
A
T
W
S
P
S
K
A
R
L
H
Site 261
S2225
M
F
A
T
W
S
P
S
K
A
R
L
H
L
Q
Site 262
T2256
L
Q
V
D
F
Q
K
T
M
K
V
T
G
V
T
Site 263
S2282
Y
V
K
E
F
L
I
S
S
S
Q
D
G
H
Q
Site 264
S2283
V
K
E
F
L
I
S
S
S
Q
D
G
H
Q
W
Site 265
S2284
K
E
F
L
I
S
S
S
Q
D
G
H
Q
W
T
Site 266
S2308
V
F
Q
G
N
Q
D
S
F
T
P
V
V
N
S
Site 267
T2310
Q
G
N
Q
D
S
F
T
P
V
V
N
S
L
D
Site 268
T2322
S
L
D
P
P
L
L
T
R
Y
L
R
I
H
P
Site 269
Y2324
D
P
P
L
L
T
R
Y
L
R
I
H
P
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation