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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GSR
Full Name:
Glutathione reductase, mitochondrial
Alias:
GLUR; glutathione reductase; GR; GRase; GRD1; GSHR
Type:
Other Amino Acids Metabolism - glutathione; EC 1.8.1.7; Oxidoreductase
Mass (Da):
56257
Number AA:
522
UniProt ID:
P00390
International Prot ID:
IPI00016862
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0050661
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
GO:0006749
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
S
A
G
A
G
P
S
W
R
R
A
A
R
A
Site 2
Y65
A
A
G
A
V
A
S
Y
D
Y
L
V
I
G
G
Site 3
Y67
G
A
V
A
S
Y
D
Y
L
V
I
G
G
G
S
Site 4
S79
G
G
S
G
G
L
A
S
A
R
R
A
A
E
L
Site 5
Y129
F
M
H
D
H
A
D
Y
G
F
P
S
C
E
G
Site 6
Y150
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Site 7
S152
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
Site 8
Y158
V
S
R
L
N
A
I
Y
Q
N
N
L
T
K
S
Site 9
T163
A
I
Y
Q
N
N
L
T
K
S
H
I
E
I
I
Site 10
T177
I
R
G
H
A
A
F
T
S
D
P
K
P
T
I
Site 11
S178
R
G
H
A
A
F
T
S
D
P
K
P
T
I
E
Site 12
T183
F
T
S
D
P
K
P
T
I
E
V
S
G
K
K
Site 13
S205
I
A
T
G
G
M
P
S
T
P
H
E
S
Q
I
Site 14
T206
A
T
G
G
M
P
S
T
P
H
E
S
Q
I
P
Site 15
S210
M
P
S
T
P
H
E
S
Q
I
P
G
A
S
L
Site 16
S216
E
S
Q
I
P
G
A
S
L
G
I
T
S
D
G
Site 17
T257
L
S
A
L
G
S
K
T
S
L
M
I
R
H
D
Site 18
S258
S
A
L
G
S
K
T
S
L
M
I
R
H
D
K
Site 19
S269
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
Site 20
S272
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
Site 21
T276
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
Site 22
T279
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
Site 23
S293
G
V
E
V
L
K
F
S
Q
V
K
E
V
K
K
Site 24
T301
Q
V
K
E
V
K
K
T
L
S
G
L
E
V
S
Site 25
T339
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
Site 26
S343
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
Site 27
T365
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
Site 28
Y371
N
T
N
V
K
G
I
Y
A
V
G
D
V
C
G
Site 29
T383
V
C
G
K
A
L
L
T
P
V
A
I
A
A
G
Site 30
Y400
L
A
H
R
L
F
E
Y
K
E
D
S
K
L
D
Site 31
Y408
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
Site 32
T413
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
Site 33
T442
Y
G
I
E
N
V
K
T
Y
S
T
S
F
T
P
Site 34
T448
K
T
Y
S
T
S
F
T
P
M
Y
H
A
V
T
Site 35
Y451
S
T
S
F
T
P
M
Y
H
A
V
T
K
R
K
Site 36
T455
T
P
M
Y
H
A
V
T
K
R
K
T
K
C
V
Site 37
T507
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
Site 38
T513
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
Site 39
S514
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
Site 40
S515
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation