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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH1A1
Full Name:
Retinal dehydrogenase 1
Alias:
AL1A1; ALDC; Aldehyde dehydrogenase family 1 member A1; ALDH class 1; ALDH1; ALDH11; ALDH-E1; ALHDII; EC 1.2.1.36; PUMB1; RalDH1
Type:
GTPase activating protein, Ras; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Apoptosis; EC 1.2.1.36
Mass (Da):
54862
Number AA:
501
UniProt ID:
P00352
International Prot ID:
IPI00218914
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005099
GO:0004029
GO:0005497
PhosphoSite+
KinaseNET
Biological Process:
GO:0006081
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
S
G
T
P
D
L
Site 2
Y20
L
T
D
L
K
I
Q
Y
T
K
I
F
I
N
N
Site 3
S75
R
Q
A
F
Q
I
G
S
P
W
R
T
M
D
A
Site 4
T79
Q
I
G
S
P
W
R
T
M
D
A
S
E
R
G
Site 5
S83
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
Site 6
Y90
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
Site 7
T105
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
Site 8
Y115
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
D
Site 9
S116
M
N
G
G
K
L
Y
S
N
A
Y
L
N
D
L
Site 10
Y119
G
K
L
Y
S
N
A
Y
L
N
D
L
A
G
C
Site 11
T153
P
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
Site 12
Y154
I
D
G
N
F
F
T
Y
T
R
H
E
P
I
G
Site 13
S261
I
K
E
A
A
G
K
S
N
L
K
R
V
T
L
Site 14
T267
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
Site 15
Y316
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
Site 16
S323
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
Site 17
Y330
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
T
Site 18
T337
Y
I
L
G
N
P
L
T
P
G
V
T
Q
G
P
Site 19
S360
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
Site 20
Y380
G
P
W
G
N
K
G
Y
F
V
Q
P
T
V
F
Site 21
T385
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
Site 22
S413
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
Site 23
T424
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
Site 24
Y426
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
Site 25
S429
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
Site 26
S472
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
Site 27
Y481
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
Site 28
Y486
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
Site 29
T491
H
E
Y
T
E
V
K
T
V
T
V
K
I
S
Q
Site 30
T493
Y
T
E
V
K
T
V
T
V
K
I
S
Q
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation