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Updated November 2019
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Protein Info
Short Name:
WHSC1
Full Name:
Probable histone-lysine N-methyltransferase NSD2
Alias:
MMSET; NSD2; Nuclear SET domain-containing protein 2; Similar to Wolf-Hirschhorn syndrome candidate 1; TRX5; WHSC1 protein; Wolf-Hirschhorn syndrome candidate 1; Wolf-Hirschhorn syndrome candidate 1(MMSET)
Type:
Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43
Mass (Da):
152258
Number AA:
1365
UniProt ID:
O96028
International Prot ID:
IPI00218240
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0018024
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0016568
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
F
S
I
K
Q
S
P
L
S
V
Q
S
V
Site 2
S30
Q
A
P
E
I
L
G
S
A
N
G
K
T
P
S
Site 3
T35
L
G
S
A
N
G
K
T
P
S
C
E
V
N
R
Site 4
S37
S
A
N
G
K
T
P
S
C
E
V
N
R
E
C
Site 5
S45
C
E
V
N
R
E
C
S
V
F
L
S
K
A
Q
Site 6
S49
R
E
C
S
V
F
L
S
K
A
Q
L
S
S
S
Site 7
S54
F
L
S
K
A
Q
L
S
S
S
L
Q
E
G
V
Site 8
S56
S
K
A
Q
L
S
S
S
L
Q
E
G
V
M
Q
Site 9
T83
A
D
K
L
K
D
L
T
S
R
V
F
N
G
E
Site 10
S84
D
K
L
K
D
L
T
S
R
V
F
N
G
E
P
Site 11
S102
D
A
K
L
R
F
E
S
Q
E
M
K
G
I
G
Site 12
T110
Q
E
M
K
G
I
G
T
P
P
N
T
T
P
I
Site 13
T114
G
I
G
T
P
P
N
T
T
P
I
K
N
G
S
Site 14
T115
I
G
T
P
P
N
T
T
P
I
K
N
G
S
P
Site 15
S121
T
T
P
I
K
N
G
S
P
E
I
K
L
K
I
Site 16
T131
I
K
L
K
I
T
K
T
Y
M
N
G
K
P
L
Site 17
Y132
K
L
K
I
T
K
T
Y
M
N
G
K
P
L
F
Site 18
S142
G
K
P
L
F
E
S
S
I
C
G
D
S
A
A
Site 19
S147
E
S
S
I
C
G
D
S
A
A
D
V
S
Q
S
Site 20
S152
G
D
S
A
A
D
V
S
Q
S
E
E
N
G
Q
Site 21
S154
S
A
A
D
V
S
Q
S
E
E
N
G
Q
K
P
Site 22
S172
A
R
R
N
R
K
R
S
I
K
Y
D
S
L
L
Site 23
Y175
N
R
K
R
S
I
K
Y
D
S
L
L
E
Q
G
Site 24
S177
K
R
S
I
K
Y
D
S
L
L
E
Q
G
L
V
Site 25
S193
A
A
L
V
S
K
I
S
S
P
S
D
K
K
I
Site 26
S194
A
L
V
S
K
I
S
S
P
S
D
K
K
I
P
Site 27
S196
V
S
K
I
S
S
P
S
D
K
K
I
P
A
K
Site 28
S206
K
I
P
A
K
K
E
S
C
P
N
T
G
R
D
Site 29
T210
K
K
E
S
C
P
N
T
G
R
D
K
D
H
L
Site 30
Y220
D
K
D
H
L
L
K
Y
N
V
G
D
L
V
W
Site 31
S248
S
A
D
P
L
L
H
S
Y
T
K
L
K
G
Q
Site 32
Y249
A
D
P
L
L
H
S
Y
T
K
L
K
G
Q
K
Site 33
S258
K
L
K
G
Q
K
K
S
A
R
Q
Y
H
V
Q
Site 34
Y262
Q
K
K
S
A
R
Q
Y
H
V
Q
F
F
G
D
Site 35
S280
R
A
W
I
F
E
K
S
L
V
A
F
E
G
E
Site 36
S315
I
K
L
L
K
P
I
S
G
K
L
R
A
Q
W
Site 37
S334
V
Q
A
E
E
A
A
S
M
S
V
E
E
R
K
Site 38
S336
A
E
E
A
A
S
M
S
V
E
E
R
K
A
K
Site 39
T345
E
E
R
K
A
K
F
T
F
L
Y
V
G
D
Q
Site 40
S369
E
A
G
I
A
A
E
S
L
G
E
M
A
E
S
Site 41
S376
S
L
G
E
M
A
E
S
S
G
V
S
E
E
A
Site 42
S377
L
G
E
M
A
E
S
S
G
V
S
E
E
A
A
Site 43
S380
M
A
E
S
S
G
V
S
E
E
A
A
E
N
P
Site 44
S389
E
A
A
E
N
P
K
S
V
R
E
E
C
I
P
Site 45
S407
R
R
R
A
K
L
C
S
S
A
E
T
L
E
S
Site 46
S408
R
R
A
K
L
C
S
S
A
E
T
L
E
S
H
Site 47
T411
K
L
C
S
S
A
E
T
L
E
S
H
P
D
I
Site 48
S414
S
S
A
E
T
L
E
S
H
P
D
I
G
K
S
Site 49
S421
S
H
P
D
I
G
K
S
T
P
Q
K
T
A
E
Site 50
T422
H
P
D
I
G
K
S
T
P
Q
K
T
A
E
A
Site 51
T426
G
K
S
T
P
Q
K
T
A
E
A
D
P
R
R
Site 52
S437
D
P
R
R
G
V
G
S
P
P
G
R
K
K
T
Site 53
T444
S
P
P
G
R
K
K
T
T
V
S
M
P
R
S
Site 54
T445
P
P
G
R
K
K
T
T
V
S
M
P
R
S
R
Site 55
S447
G
R
K
K
T
T
V
S
M
P
R
S
R
K
G
Site 56
S451
T
T
V
S
M
P
R
S
R
K
G
D
A
A
S
Site 57
S458
S
R
K
G
D
A
A
S
Q
F
L
V
F
C
Q
Site 58
S479
V
A
E
H
P
D
A
S
G
E
E
I
E
E
L
Site 59
S489
E
I
E
E
L
L
R
S
Q
W
S
L
L
S
E
Site 60
S492
E
L
L
R
S
Q
W
S
L
L
S
E
K
Q
R
Site 61
S495
R
S
Q
W
S
L
L
S
E
K
Q
R
A
R
Y
Site 62
Y502
S
E
K
Q
R
A
R
Y
N
T
K
F
A
L
V
Site 63
T504
K
Q
R
A
R
Y
N
T
K
F
A
L
V
A
P
Site 64
S518
P
V
Q
A
E
E
D
S
G
N
V
N
G
K
K
Site 65
T529
N
G
K
K
R
N
H
T
K
R
I
Q
D
P
T
Site 66
T536
T
K
R
I
Q
D
P
T
E
D
A
E
A
E
D
Site 67
T544
E
D
A
E
A
E
D
T
P
R
K
R
L
R
T
Site 68
T551
T
P
R
K
R
L
R
T
D
K
H
S
L
R
K
Site 69
S555
R
L
R
T
D
K
H
S
L
R
K
R
D
T
I
Site 70
T561
H
S
L
R
K
R
D
T
I
T
D
K
T
A
R
Site 71
T566
R
D
T
I
T
D
K
T
A
R
T
S
S
Y
K
Site 72
S570
T
D
K
T
A
R
T
S
S
Y
K
A
M
E
A
Site 73
S571
D
K
T
A
R
T
S
S
Y
K
A
M
E
A
A
Site 74
S579
Y
K
A
M
E
A
A
S
S
L
K
S
Q
A
A
Site 75
S580
K
A
M
E
A
A
S
S
L
K
S
Q
A
A
T
Site 76
S583
E
A
A
S
S
L
K
S
Q
A
A
T
K
N
L
Site 77
T587
S
L
K
S
Q
A
A
T
K
N
L
S
D
A
C
Site 78
S591
Q
A
A
T
K
N
L
S
D
A
C
K
P
L
K
Site 79
S604
L
K
K
R
N
R
A
S
T
A
A
S
S
A
L
Site 80
T605
K
K
R
N
R
A
S
T
A
A
S
S
A
L
G
Site 81
S608
N
R
A
S
T
A
A
S
S
A
L
G
F
S
K
Site 82
S609
R
A
S
T
A
A
S
S
A
L
G
F
S
K
S
Site 83
S614
A
S
S
A
L
G
F
S
K
S
S
S
P
S
A
Site 84
S616
S
A
L
G
F
S
K
S
S
S
P
S
A
S
L
Site 85
S617
A
L
G
F
S
K
S
S
S
P
S
A
S
L
T
Site 86
S618
L
G
F
S
K
S
S
S
P
S
A
S
L
T
E
Site 87
S620
F
S
K
S
S
S
P
S
A
S
L
T
E
N
E
Site 88
S622
K
S
S
S
P
S
A
S
L
T
E
N
E
V
S
Site 89
T624
S
S
P
S
A
S
L
T
E
N
E
V
S
D
S
Site 90
S629
S
L
T
E
N
E
V
S
D
S
P
G
D
E
P
Site 91
S631
T
E
N
E
V
S
D
S
P
G
D
E
P
S
E
Site 92
S637
D
S
P
G
D
E
P
S
E
S
P
Y
E
S
A
Site 93
S639
P
G
D
E
P
S
E
S
P
Y
E
S
A
D
E
Site 94
Y641
D
E
P
S
E
S
P
Y
E
S
A
D
E
T
Q
Site 95
S643
P
S
E
S
P
Y
E
S
A
D
E
T
Q
T
E
Site 96
T647
P
Y
E
S
A
D
E
T
Q
T
E
V
S
V
S
Site 97
T649
E
S
A
D
E
T
Q
T
E
V
S
V
S
S
K
Site 98
S652
D
E
T
Q
T
E
V
S
V
S
S
K
K
S
E
Site 99
S654
T
Q
T
E
V
S
V
S
S
K
K
S
E
R
G
Site 100
S658
V
S
V
S
S
K
K
S
E
R
G
V
T
A
K
Site 101
T663
K
K
S
E
R
G
V
T
A
K
K
E
Y
V
C
Site 102
Y668
G
V
T
A
K
K
E
Y
V
C
Q
L
C
E
K
Site 103
S678
Q
L
C
E
K
P
G
S
L
L
L
C
E
G
P
Site 104
S698
H
L
A
C
L
G
L
S
R
R
P
E
G
R
F
Site 105
T706
R
R
P
E
G
R
F
T
C
S
E
C
A
S
G
Site 106
S708
P
E
G
R
F
T
C
S
E
C
A
S
G
I
H
Site 107
Y747
H
E
A
C
V
K
K
Y
P
L
T
V
F
E
S
Site 108
T750
C
V
K
K
Y
P
L
T
V
F
E
S
R
G
F
Site 109
S754
Y
P
L
T
V
F
E
S
R
G
F
R
C
P
L
Site 110
S770
S
C
V
S
C
H
A
S
N
P
S
N
P
R
P
Site 111
S773
S
C
H
A
S
N
P
S
N
P
R
P
S
K
G
Site 112
S778
N
P
S
N
P
R
P
S
K
G
K
M
M
R
C
Site 113
T818
I
I
C
T
A
H
F
T
A
R
K
G
K
R
H
Site 114
Y928
F
F
F
G
S
K
D
Y
Y
W
T
H
Q
A
R
Site 115
Y929
F
F
G
S
K
D
Y
Y
W
T
H
Q
A
R
V
Site 116
S946
Y
M
E
G
D
R
G
S
R
Y
Q
G
V
R
G
Site 117
Y948
E
G
D
R
G
S
R
Y
Q
G
V
R
G
I
G
Site 118
T981
L
Q
R
E
A
R
E
T
Q
E
S
E
R
K
P
Site 119
S984
E
A
R
E
T
Q
E
S
E
R
K
P
P
P
Y
Site 120
Y991
S
E
R
K
P
P
P
Y
K
H
I
K
V
N
K
Site 121
Y1006
P
Y
G
K
V
Q
I
Y
T
A
D
I
S
E
I
Site 122
Y1062
Q
C
F
T
K
R
Q
Y
P
E
T
K
I
I
K
Site 123
T1065
T
K
R
Q
Y
P
E
T
K
I
I
K
T
D
G
Site 124
T1070
P
E
T
K
I
I
K
T
D
G
K
G
W
G
L
Site 125
Y1092
K
G
E
F
V
N
E
Y
V
G
E
L
I
D
E
Site 126
Y1118
E
N
D
I
T
H
F
Y
M
L
T
I
D
K
D
Site 127
Y1136
D
A
G
P
K
G
N
Y
S
R
F
M
N
H
S
Site 128
T1154
N
C
E
T
L
K
W
T
V
N
G
D
T
R
V
Site 129
T1176
I
P
A
G
T
E
L
T
F
N
Y
N
L
D
C
Site 130
Y1179
G
T
E
L
T
F
N
Y
N
L
D
C
L
G
N
Site 131
T1189
D
C
L
G
N
E
K
T
V
C
R
C
G
A
S
Site 132
T1208
F
L
G
D
R
P
K
T
S
T
T
L
S
S
E
Site 133
S1209
L
G
D
R
P
K
T
S
T
T
L
S
S
E
E
Site 134
T1210
G
D
R
P
K
T
S
T
T
L
S
S
E
E
K
Site 135
T1211
D
R
P
K
T
S
T
T
L
S
S
E
E
K
G
Site 136
S1213
P
K
T
S
T
T
L
S
S
E
E
K
G
K
K
Site 137
T1225
G
K
K
T
K
K
K
T
R
R
R
R
A
K
G
Site 138
S1238
K
G
E
G
K
R
Q
S
E
D
E
C
F
R
C
Site 139
S1314
H
Q
D
G
T
A
F
S
C
T
P
D
G
R
S
Site 140
T1316
D
G
T
A
F
S
C
T
P
D
G
R
S
Y
C
Site 141
Y1322
C
T
P
D
G
R
S
Y
C
C
E
H
D
L
G
Site 142
S1332
E
H
D
L
G
A
A
S
V
R
S
T
K
T
E
Site 143
T1336
G
A
A
S
V
R
S
T
K
T
E
K
P
P
P
Site 144
T1338
A
S
V
R
S
T
K
T
E
K
P
P
P
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation