KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Cyclin E2
Full Name:
G1/S-specific cyclin-E2
Alias:
CCNE2; CGE2; CYCE2
Type:
Protein-serine kinase regulatory subunit, activator, cyclin
Mass (Da):
46757
Number AA:
404
UniProt ID:
O96020
International Prot ID:
IPI00014085
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0016538
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0000075
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
R
R
S
S
R
L
Q
A
K
Q
Site 2
S6
_
_
M
S
R
R
S
S
R
L
Q
A
K
Q
Q
Site 3
S17
A
K
Q
Q
P
Q
P
S
Q
T
E
S
P
Q
E
Site 4
T19
Q
Q
P
Q
P
S
Q
T
E
S
P
Q
E
A
Q
Site 5
S21
P
Q
P
S
Q
T
E
S
P
Q
E
A
Q
I
I
Site 6
T35
I
Q
A
K
K
R
K
T
T
Q
D
V
K
K
R
Site 7
T36
Q
A
K
K
R
K
T
T
Q
D
V
K
K
R
R
Site 8
T47
K
K
R
R
E
E
V
T
K
K
H
Q
Y
E
I
Site 9
Y52
E
V
T
K
K
H
Q
Y
E
I
R
N
C
W
P
Site 10
S63
N
C
W
P
P
V
L
S
G
G
I
S
P
C
I
Site 11
T74
S
P
C
I
I
I
E
T
P
H
K
E
I
G
T
Site 12
S82
P
H
K
E
I
G
T
S
D
F
S
R
F
T
N
Site 13
T88
T
S
D
F
S
R
F
T
N
Y
R
F
K
N
L
Site 14
S100
K
N
L
F
I
N
P
S
P
L
P
D
L
S
W
Site 15
S106
P
S
P
L
P
D
L
S
W
G
C
S
K
E
V
Site 16
Y124
M
L
K
K
E
S
R
Y
V
H
D
K
H
F
E
Site 17
S135
K
H
F
E
V
L
H
S
D
L
E
P
Q
M
R
Site 18
T157
L
E
V
C
E
V
Y
T
L
H
R
E
T
F
Y
Site 19
T162
V
Y
T
L
H
R
E
T
F
Y
L
A
Q
D
F
Site 20
Y164
T
L
H
R
E
T
F
Y
L
A
Q
D
F
F
D
Site 21
Y212
P
K
L
Q
E
F
A
Y
V
T
D
G
A
C
S
Site 22
Y267
P
K
V
L
L
P
Q
Y
S
Q
E
T
F
I
Q
Site 23
S268
K
V
L
L
P
Q
Y
S
Q
E
T
F
I
Q
I
Site 24
S320
A
S
G
L
E
W
D
S
I
S
E
C
V
D
W
Site 25
S337
P
F
V
N
V
V
K
S
T
S
P
V
K
L
K
Site 26
T345
T
S
P
V
K
L
K
T
F
K
K
I
P
M
E
Site 27
Y363
N
I
Q
T
H
T
N
Y
L
A
M
L
E
E
V
Site 28
Y372
A
M
L
E
E
V
N
Y
I
N
T
F
R
K
G
Site 29
T375
E
E
V
N
Y
I
N
T
F
R
K
G
G
Q
L
Site 30
S383
F
R
K
G
G
Q
L
S
P
V
C
N
G
G
I
Site 31
T392
V
C
N
G
G
I
M
T
P
P
K
S
T
E
K
Site 32
S396
G
I
M
T
P
P
K
S
T
E
K
P
P
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation