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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Bcl-10
Full Name:
B-cell lymphoma/leukemia 10
Alias:
B-cell CLL/lymphoma 10; BCL10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; Caspase-recruiting domain-containing protein; CCARMEN; C-E10; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; CLAP; HCLAP; Mammalian CARD-containing adapter molecule E10; ME10
Type:
Apoptosis
Mass (Da):
26252
Number AA:
233
UniProt ID:
O95999
International Prot ID:
IPI00022477
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032449
GO:0005829
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0008022
GO:0043422
PhosphoSite+
KinaseNET
Biological Process:
GO:0050852
GO:0006915
GO:0045087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
E
P
T
A
P
S
L
T
E
E
Site 2
T14
S
L
T
E
E
D
L
T
E
V
K
K
D
A
L
Site 3
S48
L
R
A
K
K
I
L
S
R
E
D
T
E
E
I
Site 4
T52
K
I
L
S
R
E
D
T
E
E
I
S
C
R
T
Site 5
S56
R
E
D
T
E
E
I
S
C
R
T
S
S
R
K
Site 6
T59
T
E
E
I
S
C
R
T
S
S
R
K
R
A
G
Site 7
S60
E
E
I
S
C
R
T
S
S
R
K
R
A
G
K
Site 8
S61
E
I
S
C
R
T
S
S
R
K
R
A
G
K
L
Site 9
Y71
R
A
G
K
L
L
D
Y
L
Q
E
N
P
K
G
Site 10
T81
E
N
P
K
G
L
D
T
L
V
E
S
I
R
R
Site 11
S85
G
L
D
T
L
V
E
S
I
R
R
E
K
T
Q
Site 12
T91
E
S
I
R
R
E
K
T
Q
N
F
L
I
Q
K
Site 13
T100
N
F
L
I
Q
K
I
T
D
E
V
L
K
L
R
Site 14
S121
L
K
G
L
K
C
S
S
C
E
P
F
P
D
G
Site 15
T130
E
P
F
P
D
G
A
T
N
N
L
S
R
S
N
Site 16
S134
D
G
A
T
N
N
L
S
R
S
N
S
D
E
S
Site 17
S136
A
T
N
N
L
S
R
S
N
S
D
E
S
N
F
Site 18
S138
N
N
L
S
R
S
N
S
D
E
S
N
F
S
E
Site 19
S141
S
R
S
N
S
D
E
S
N
F
S
E
K
L
R
Site 20
S144
N
S
D
E
S
N
F
S
E
K
L
R
A
S
T
Site 21
S150
F
S
E
K
L
R
A
S
T
V
M
Y
H
P
E
Site 22
T151
S
E
K
L
R
A
S
T
V
M
Y
H
P
E
G
Site 23
Y154
L
R
A
S
T
V
M
Y
H
P
E
G
E
S
S
Site 24
S161
Y
H
P
E
G
E
S
S
T
T
P
F
F
S
T
Site 25
T163
P
E
G
E
S
S
T
T
P
F
F
S
T
N
S
Site 26
S167
S
S
T
T
P
F
F
S
T
N
S
S
L
N
L
Site 27
T168
S
T
T
P
F
F
S
T
N
S
S
L
N
L
P
Site 28
S170
T
P
F
F
S
T
N
S
S
L
N
L
P
V
L
Site 29
S171
P
F
F
S
T
N
S
S
L
N
L
P
V
L
E
Site 30
T182
P
V
L
E
V
G
R
T
E
N
T
I
F
S
S
Site 31
T185
E
V
G
R
T
E
N
T
I
F
S
S
T
T
L
Site 32
T190
E
N
T
I
F
S
S
T
T
L
P
R
P
G
D
Site 33
T214
L
Q
L
E
E
E
G
T
C
A
N
S
S
E
M
Site 34
S218
E
E
G
T
C
A
N
S
S
E
M
F
L
P
L
Site 35
S219
E
G
T
C
A
N
S
S
E
M
F
L
P
L
R
Site 36
S227
E
M
F
L
P
L
R
S
R
T
V
S
R
Q
_
Site 37
T229
F
L
P
L
R
S
R
T
V
S
R
Q
_
_
_
Site 38
S231
P
L
R
S
R
T
V
S
R
Q
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation