KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
APC2
Full Name:
Adenomatous polyposis coli protein 2
Alias:
Adenomatosis polyposis coli 2; Adenomatous polyposis coli like; Adenomatous polyposis coli protein-like; APCL
Type:
Cytoplasm › cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Mass (Da):
243949
Number AA:
2303
UniProt ID:
O95996
International Prot ID:
IPI00017891
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016342
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0008013
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0006461
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
E
A
L
K
A
E
N
S
H
L
R
Q
E
L
R
Site 2
S33
R
Q
E
L
R
D
N
S
S
H
L
S
K
L
E
Site 3
S34
Q
E
L
R
D
N
S
S
H
L
S
K
L
E
T
Site 4
S37
R
D
N
S
S
H
L
S
K
L
E
T
E
T
S
Site 5
T41
S
H
L
S
K
L
E
T
E
T
S
G
M
K
E
Site 6
S44
S
K
L
E
T
E
T
S
G
M
K
E
V
L
K
Site 7
S67
E
A
R
V
L
V
S
S
G
Q
T
E
V
L
E
Site 8
T84
K
A
L
Q
M
D
I
T
S
L
Y
N
L
K
F
Site 9
Y87
Q
M
D
I
T
S
L
Y
N
L
K
F
Q
P
P
Site 10
T95
N
L
K
F
Q
P
P
T
L
G
P
E
P
A
A
Site 11
T104
G
P
E
P
A
A
R
T
P
E
G
S
P
V
H
Site 12
S108
A
A
R
T
P
E
G
S
P
V
H
G
S
G
P
Site 13
S113
E
G
S
P
V
H
G
S
G
P
S
K
D
S
F
Site 14
S116
P
V
H
G
S
G
P
S
K
D
S
F
G
E
L
Site 15
S119
G
S
G
P
S
K
D
S
F
G
E
L
S
R
A
Site 16
S124
K
D
S
F
G
E
L
S
R
A
T
I
R
L
L
Site 17
Y155
E
E
K
E
K
L
W
Y
Y
S
Q
L
Q
G
L
Site 18
Y156
E
K
E
K
L
W
Y
Y
S
Q
L
Q
G
L
S
Site 19
S157
K
E
K
L
W
Y
Y
S
Q
L
Q
G
L
S
K
Site 20
S196
F
E
A
Q
H
I
R
S
L
M
E
E
R
F
G
Site 21
T204
L
M
E
E
R
F
G
T
S
D
E
M
V
Q
R
Site 22
S217
Q
R
A
Q
I
R
A
S
R
L
E
Q
I
D
K
Site 23
T255
P
V
D
E
D
P
E
T
E
V
P
T
H
P
E
Site 24
T265
P
T
H
P
E
D
G
T
P
Q
P
G
N
S
K
Site 25
T285
W
L
L
S
M
L
A
T
R
D
Q
E
D
T
A
Site 26
T291
A
T
R
D
Q
E
D
T
A
R
T
L
L
A
M
Site 27
S304
A
M
S
S
S
P
E
S
C
V
A
M
R
R
S
Site 28
S402
P
E
G
G
G
A
G
S
A
P
I
P
I
E
P
Site 29
S422
T
C
A
V
M
K
L
S
F
D
E
E
Y
R
R
Site 30
Y427
K
L
S
F
D
E
E
Y
R
R
A
M
N
E
L
Site 31
Y448
A
E
L
L
Q
V
D
Y
E
M
H
K
M
T
R
Site 32
T454
D
Y
E
M
H
K
M
T
R
D
P
L
N
L
A
Site 33
S500
A
I
V
A
Q
L
A
S
D
S
E
E
L
H
Q
Site 34
S502
V
A
Q
L
A
S
D
S
E
E
L
H
Q
V
V
Site 35
S510
E
E
L
H
Q
V
V
S
S
I
L
R
N
L
S
Site 36
S511
E
L
H
Q
V
V
S
S
I
L
R
N
L
S
W
Site 37
S517
S
S
I
L
R
N
L
S
W
R
A
D
I
N
S
Site 38
S524
S
W
R
A
D
I
N
S
K
K
V
L
R
E
A
Site 39
T545
V
Q
C
V
L
R
A
T
K
E
S
T
L
K
S
Site 40
S548
V
L
R
A
T
K
E
S
T
L
K
S
V
L
S
Site 41
T549
L
R
A
T
K
E
S
T
L
K
S
V
L
S
A
Site 42
S552
T
K
E
S
T
L
K
S
V
L
S
A
L
W
N
Site 43
S561
L
S
A
L
W
N
L
S
A
H
S
T
E
N
K
Site 44
T565
W
N
L
S
A
H
S
T
E
N
K
A
A
I
C
Site 45
T586
G
F
L
V
S
T
L
T
Y
K
C
Q
S
N
S
Site 46
S593
T
Y
K
C
Q
S
N
S
L
A
I
I
E
S
G
Site 47
S609
G
I
L
R
N
V
S
S
L
V
A
T
R
E
D
Site 48
Y617
L
V
A
T
R
E
D
Y
R
Q
V
L
R
D
H
Site 49
T629
R
D
H
N
C
L
Q
T
L
L
Q
H
L
T
S
Site 50
S653
C
G
T
L
W
N
L
S
A
R
S
A
R
D
Q
Site 51
S678
M
L
R
N
L
V
H
S
K
H
K
M
I
A
M
Site 52
S717
S
P
G
S
C
V
P
S
L
Y
V
R
K
Q
R
Site 53
Y719
G
S
C
V
P
S
L
Y
V
R
K
Q
R
A
L
Site 54
Y771
L
D
G
L
A
Q
D
Y
A
S
D
S
G
C
F
Site 55
S773
G
L
A
Q
D
Y
A
S
D
S
G
C
F
D
D
Site 56
S775
A
Q
D
Y
A
S
D
S
G
C
F
D
D
D
D
Site 57
S786
D
D
D
D
A
P
S
S
L
A
A
A
A
A
T
Site 58
T819
Q
G
Q
A
L
A
R
T
P
P
T
R
R
G
G
Site 59
T822
A
L
A
R
T
P
P
T
R
R
G
G
K
E
A
Site 60
S834
K
E
A
E
K
D
T
S
G
E
A
A
V
A
A
Site 61
S862
D
Q
L
V
E
D
I
S
A
L
H
T
S
S
D
Site 62
T866
E
D
I
S
A
L
H
T
S
S
D
D
S
F
S
Site 63
S867
D
I
S
A
L
H
T
S
S
D
D
S
F
S
L
Site 64
S868
I
S
A
L
H
T
S
S
D
D
S
F
S
L
S
Site 65
S871
L
H
T
S
S
D
D
S
F
S
L
S
S
G
D
Site 66
S873
T
S
S
D
D
S
F
S
L
S
S
G
D
P
G
Site 67
S875
S
D
D
S
F
S
L
S
S
G
D
P
G
Q
E
Site 68
S891
P
R
E
G
R
A
Q
S
C
S
P
C
R
G
P
Site 69
S893
E
G
R
A
Q
S
C
S
P
C
R
G
P
E
G
Site 70
S907
G
G
R
R
E
A
G
S
R
A
H
P
L
L
R
Site 71
S921
R
L
K
A
A
H
A
S
L
S
N
D
S
L
N
Site 72
S923
K
A
A
H
A
S
L
S
N
D
S
L
N
S
G
Site 73
S926
H
A
S
L
S
N
D
S
L
N
S
G
S
A
S
Site 74
S929
L
S
N
D
S
L
N
S
G
S
A
S
D
G
Y
Site 75
S931
N
D
S
L
N
S
G
S
A
S
D
G
Y
C
P
Site 76
S933
S
L
N
S
G
S
A
S
D
G
Y
C
P
R
E
Site 77
Y936
S
G
S
A
S
D
G
Y
C
P
R
E
H
M
L
Site 78
S952
C
P
L
A
A
L
A
S
R
R
E
D
P
R
C
Site 79
S965
R
C
G
Q
P
R
P
S
R
L
D
L
D
L
P
Site 80
T984
E
P
P
A
R
E
A
T
S
A
D
A
R
V
R
Site 81
T992
S
A
D
A
R
V
R
T
I
K
L
S
P
T
Y
Site 82
S996
R
V
R
T
I
K
L
S
P
T
Y
Q
H
V
P
Site 83
T998
R
T
I
K
L
S
P
T
Y
Q
H
V
P
L
L
Site 84
Y999
T
I
K
L
S
P
T
Y
Q
H
V
P
L
L
E
Site 85
S1022
P
L
A
G
P
G
I
S
P
G
A
R
K
Q
A
Site 86
S1037
W
L
P
A
D
H
L
S
K
V
P
E
K
L
A
Site 87
S1066
A
A
Q
E
G
P
L
S
L
S
R
C
S
S
L
Site 88
S1068
Q
E
G
P
L
S
L
S
R
C
S
S
L
S
S
Site 89
S1071
P
L
S
L
S
R
C
S
S
L
S
S
L
S
S
Site 90
S1074
L
S
R
C
S
S
L
S
S
L
S
S
A
G
R
Site 91
S1075
S
R
C
S
S
L
S
S
L
S
S
A
G
R
P
Site 92
S1077
C
S
S
L
S
S
L
S
S
A
G
R
P
G
P
Site 93
S1078
S
S
L
S
S
L
S
S
A
G
R
P
G
P
S
Site 94
S1093
E
G
G
D
L
D
D
S
D
S
S
L
E
G
L
Site 95
S1095
G
D
L
D
D
S
D
S
S
L
E
G
L
E
E
Site 96
S1096
D
L
D
D
S
D
S
S
L
E
G
L
E
E
A
Site 97
S1106
G
L
E
E
A
G
P
S
E
A
E
L
D
S
T
Site 98
S1112
P
S
E
A
E
L
D
S
T
W
R
A
P
G
A
Site 99
T1113
S
E
A
E
L
D
S
T
W
R
A
P
G
A
T
Site 100
T1143
G
L
G
V
E
D
A
T
P
S
S
S
S
E
N
Site 101
S1145
G
V
E
D
A
T
P
S
S
S
S
E
N
Y
V
Site 102
S1146
V
E
D
A
T
P
S
S
S
S
E
N
Y
V
Q
Site 103
S1148
D
A
T
P
S
S
S
S
E
N
Y
V
Q
E
T
Site 104
Y1151
P
S
S
S
S
E
N
Y
V
Q
E
T
P
L
V
Site 105
T1155
S
E
N
Y
V
Q
E
T
P
L
V
L
S
R
C
Site 106
S1160
Q
E
T
P
L
V
L
S
R
C
S
S
V
S
S
Site 107
S1166
L
S
R
C
S
S
V
S
S
L
G
S
F
E
S
Site 108
S1167
S
R
C
S
S
V
S
S
L
G
S
F
E
S
P
Site 109
S1170
S
S
V
S
S
L
G
S
F
E
S
P
S
I
A
Site 110
S1178
F
E
S
P
S
I
A
S
S
I
P
S
E
P
C
Site 111
S1179
E
S
P
S
I
A
S
S
I
P
S
E
P
C
S
Site 112
S1182
S
I
A
S
S
I
P
S
E
P
C
S
G
Q
G
Site 113
S1186
S
I
P
S
E
P
C
S
G
Q
G
S
G
T
I
Site 114
S1190
E
P
C
S
G
Q
G
S
G
T
I
S
P
S
E
Site 115
T1192
C
S
G
Q
G
S
G
T
I
S
P
S
E
L
P
Site 116
S1194
G
Q
G
S
G
T
I
S
P
S
E
L
P
D
S
Site 117
S1196
G
S
G
T
I
S
P
S
E
L
P
D
S
P
G
Site 118
S1201
S
P
S
E
L
P
D
S
P
G
Q
T
M
P
P
Site 119
T1205
L
P
D
S
P
G
Q
T
M
P
P
S
R
S
K
Site 120
S1209
P
G
Q
T
M
P
P
S
R
S
K
T
P
P
L
Site 121
S1211
Q
T
M
P
P
S
R
S
K
T
P
P
L
A
P
Site 122
T1213
M
P
P
S
R
S
K
T
P
P
L
A
P
A
P
Site 123
S1230
P
P
E
A
T
Q
F
S
L
Q
W
E
S
Y
V
Site 124
Y1236
F
S
L
Q
W
E
S
Y
V
K
R
F
L
D
I
Site 125
S1254
R
E
R
C
R
L
P
S
E
L
D
A
G
S
V
Site 126
S1260
P
S
E
L
D
A
G
S
V
R
F
T
V
E
K
Site 127
T1264
D
A
G
S
V
R
F
T
V
E
K
P
D
E
N
Site 128
S1273
E
K
P
D
E
N
F
S
C
A
S
S
L
S
A
Site 129
S1277
E
N
F
S
C
A
S
S
L
S
A
L
A
L
H
Site 130
S1279
F
S
C
A
S
S
L
S
A
L
A
L
H
E
H
Site 131
Y1287
A
L
A
L
H
E
H
Y
V
Q
Q
D
V
E
L
Site 132
S1299
V
E
L
R
L
L
P
S
A
C
P
E
R
G
G
Site 133
S1330
E
G
P
A
P
T
G
S
R
P
R
G
A
A
D
Site 134
S1360
A
R
L
R
K
V
A
S
A
L
V
P
G
R
R
Site 135
Y1374
R
A
L
P
V
P
V
Y
M
L
V
P
A
P
A
Site 136
S1388
A
P
A
Q
E
D
D
S
C
T
D
S
A
E
G
Site 137
T1390
A
Q
E
D
D
S
C
T
D
S
A
E
G
T
P
Site 138
S1392
E
D
D
S
C
T
D
S
A
E
G
T
P
V
N
Site 139
T1396
C
T
D
S
A
E
G
T
P
V
N
F
S
S
A
Site 140
S1401
E
G
T
P
V
N
F
S
S
A
A
S
L
S
D
Site 141
S1402
G
T
P
V
N
F
S
S
A
A
S
L
S
D
E
Site 142
S1405
V
N
F
S
S
A
A
S
L
S
D
E
T
L
Q
Site 143
S1407
F
S
S
A
A
S
L
S
D
E
T
L
Q
G
P
Site 144
T1410
A
A
S
L
S
D
E
T
L
Q
G
P
P
R
D
Site 145
T1429
P
A
G
R
Q
R
P
T
G
R
P
T
S
A
R
Site 146
T1433
Q
R
P
T
G
R
P
T
S
A
R
Q
A
M
G
Site 147
S1434
R
P
T
G
R
P
T
S
A
R
Q
A
M
G
H
Site 148
S1451
K
A
G
G
A
G
R
S
A
E
Q
S
R
G
A
Site 149
S1455
A
G
R
S
A
E
Q
S
R
G
A
G
K
N
R
Site 150
S1474
L
P
L
G
R
P
P
S
A
P
A
D
K
D
G
Site 151
S1482
A
P
A
D
K
D
G
S
K
P
G
R
T
R
G
Site 152
S1495
R
G
D
G
A
L
Q
S
L
C
L
T
T
P
T
Site 153
Y1507
T
P
T
E
E
A
V
Y
C
F
Y
G
N
D
S
Site 154
Y1510
E
E
A
V
Y
C
F
Y
G
N
D
S
D
E
E
Site 155
S1514
Y
C
F
Y
G
N
D
S
D
E
E
P
P
A
A
Site 156
T1524
E
P
P
A
A
A
P
T
P
T
H
R
R
T
S
Site 157
T1526
P
A
A
A
P
T
P
T
H
R
R
T
S
A
I
Site 158
T1530
P
T
P
T
H
R
R
T
S
A
I
P
R
A
F
Site 159
S1531
T
P
T
H
R
R
T
S
A
I
P
R
A
F
T
Site 160
T1538
S
A
I
P
R
A
F
T
R
E
R
P
Q
G
R
Site 161
T1573
P
S
L
I
A
D
E
T
P
P
C
Y
S
L
S
Site 162
Y1577
A
D
E
T
P
P
C
Y
S
L
S
S
S
A
S
Site 163
S1578
D
E
T
P
P
C
Y
S
L
S
S
S
A
S
S
Site 164
S1580
T
P
P
C
Y
S
L
S
S
S
A
S
S
L
S
Site 165
S1581
P
P
C
Y
S
L
S
S
S
A
S
S
L
S
E
Site 166
S1582
P
C
Y
S
L
S
S
S
A
S
S
L
S
E
P
Site 167
S1584
Y
S
L
S
S
S
A
S
S
L
S
E
P
E
P
Site 168
S1585
S
L
S
S
S
A
S
S
L
S
E
P
E
P
S
Site 169
S1587
S
S
S
A
S
S
L
S
E
P
E
P
S
E
P
Site 170
S1592
S
L
S
E
P
E
P
S
E
P
P
A
V
H
P
Site 171
T1607
R
G
R
E
P
A
V
T
K
D
P
G
P
G
G
Site 172
S1618
G
P
G
G
G
R
D
S
S
P
S
P
R
A
A
Site 173
S1619
P
G
G
G
R
D
S
S
P
S
P
R
A
A
E
Site 174
S1621
G
G
R
D
S
S
P
S
P
R
A
A
E
E
L
Site 175
S1634
E
L
L
Q
R
C
I
S
S
A
L
P
R
R
R
Site 176
S1645
P
R
R
R
P
P
V
S
G
L
R
R
R
K
P
Site 177
T1655
R
R
R
K
P
R
A
T
R
L
D
E
R
P
A
Site 178
S1665
D
E
R
P
A
E
G
S
R
E
R
G
E
E
A
Site 179
S1675
R
G
E
E
A
A
G
S
D
R
A
S
D
L
D
Site 180
S1679
A
A
G
S
D
R
A
S
D
L
D
S
V
E
W
Site 181
S1683
D
R
A
S
D
L
D
S
V
E
W
R
A
I
Q
Site 182
S1711
A
A
A
T
R
E
A
S
S
E
S
D
S
I
L
Site 183
S1712
A
A
T
R
E
A
S
S
E
S
D
S
I
L
S
Site 184
S1714
T
R
E
A
S
S
E
S
D
S
I
L
S
F
V
Site 185
S1716
E
A
S
S
E
S
D
S
I
L
S
F
V
S
G
Site 186
T1729
S
G
L
S
V
G
S
T
L
Q
P
P
K
H
R
Site 187
S1747
Q
A
E
G
E
M
G
S
A
R
R
P
E
K
R
Site 188
S1758
P
E
K
R
G
A
A
S
V
K
T
S
G
S
P
Site 189
S1762
G
A
A
S
V
K
T
S
G
S
P
R
S
P
A
Site 190
S1764
A
S
V
K
T
S
G
S
P
R
S
P
A
G
P
Site 191
S1767
K
T
S
G
S
P
R
S
P
A
G
P
E
K
P
Site 192
T1777
G
P
E
K
P
R
G
T
Q
K
T
T
P
G
V
Site 193
T1780
K
P
R
G
T
Q
K
T
T
P
G
V
P
A
V
Site 194
T1781
P
R
G
T
Q
K
T
T
P
G
V
P
A
V
L
Site 195
Y1795
L
R
G
R
T
V
I
Y
V
P
S
P
A
P
R
Site 196
S1798
R
T
V
I
Y
V
P
S
P
A
P
R
A
Q
P
Site 197
T1808
P
R
A
Q
P
K
G
T
P
G
P
R
A
T
P
Site 198
T1814
G
T
P
G
P
R
A
T
P
R
K
V
A
P
P
Site 199
S1834
A
A
P
A
K
V
P
S
P
G
Q
Q
R
S
R
Site 200
S1840
P
S
P
G
Q
Q
R
S
R
S
L
H
R
P
A
Site 201
S1842
P
G
Q
Q
R
S
R
S
L
H
R
P
A
K
T
Site 202
S1850
L
H
R
P
A
K
T
S
E
L
A
T
L
S
Q
Site 203
T1854
A
K
T
S
E
L
A
T
L
S
Q
P
P
R
S
Site 204
S1856
T
S
E
L
A
T
L
S
Q
P
P
R
S
A
T
Site 205
S1861
T
L
S
Q
P
P
R
S
A
T
P
P
A
R
L
Site 206
T1863
S
Q
P
P
R
S
A
T
P
P
A
R
L
A
K
Site 207
T1871
P
P
A
R
L
A
K
T
P
S
S
S
S
S
Q
Site 208
S1873
A
R
L
A
K
T
P
S
S
S
S
S
Q
T
S
Site 209
S1874
R
L
A
K
T
P
S
S
S
S
S
Q
T
S
P
Site 210
S1875
L
A
K
T
P
S
S
S
S
S
Q
T
S
P
A
Site 211
S1876
A
K
T
P
S
S
S
S
S
Q
T
S
P
A
S
Site 212
S1877
K
T
P
S
S
S
S
S
Q
T
S
P
A
S
Q
Site 213
T1879
P
S
S
S
S
S
Q
T
S
P
A
S
Q
P
L
Site 214
S1880
S
S
S
S
S
Q
T
S
P
A
S
Q
P
L
P
Site 215
S1883
S
S
Q
T
S
P
A
S
Q
P
L
P
R
K
R
Site 216
T1894
P
R
K
R
P
P
V
T
Q
A
A
G
A
L
P
Site 217
S1906
A
L
P
G
P
G
A
S
P
V
P
K
T
P
A
Site 218
T1923
L
L
A
K
Q
H
K
T
Q
R
S
P
V
R
I
Site 219
S1926
K
Q
H
K
T
Q
R
S
P
V
R
I
P
F
M
Site 220
T1959
G
P
R
G
R
A
G
T
E
A
G
P
G
A
R
Site 221
S1977
L
G
L
V
R
V
A
S
A
L
S
S
G
S
E
Site 222
S1980
V
R
V
A
S
A
L
S
S
G
S
E
S
S
D
Site 223
S1981
R
V
A
S
A
L
S
S
G
S
E
S
S
D
R
Site 224
S1983
A
S
A
L
S
S
G
S
E
S
S
D
R
S
G
Site 225
S1985
A
L
S
S
G
S
E
S
S
D
R
S
G
F
R
Site 226
S1986
L
S
S
G
S
E
S
S
D
R
S
G
F
R
R
Site 227
S1989
G
S
E
S
S
D
R
S
G
F
R
R
Q
L
T
Site 228
T1996
S
G
F
R
R
Q
L
T
F
I
K
E
S
P
G
Site 229
S2001
Q
L
T
F
I
K
E
S
P
G
L
R
R
R
R
Site 230
S2009
P
G
L
R
R
R
R
S
E
L
S
S
A
E
S
Site 231
S2012
R
R
R
R
S
E
L
S
S
A
E
S
A
A
S
Site 232
S2013
R
R
R
S
E
L
S
S
A
E
S
A
A
S
A
Site 233
S2016
S
E
L
S
S
A
E
S
A
A
S
A
P
Q
G
Site 234
S2019
S
S
A
E
S
A
A
S
A
P
Q
G
A
S
P
Site 235
S2025
A
S
A
P
Q
G
A
S
P
R
R
G
R
P
A
Site 236
S2041
P
A
V
F
L
C
S
S
R
C
E
E
L
R
A
Site 237
S2067
R
P
P
A
A
R
P
S
P
G
E
R
P
A
R
Site 238
T2076
G
E
R
P
A
R
R
T
T
S
E
S
P
S
R
Site 239
T2077
E
R
P
A
R
R
T
T
S
E
S
P
S
R
L
Site 240
S2078
R
P
A
R
R
T
T
S
E
S
P
S
R
L
P
Site 241
S2080
A
R
R
T
T
S
E
S
P
S
R
L
P
V
R
Site 242
S2082
R
T
T
S
E
S
P
S
R
L
P
V
R
A
P
Site 243
T2095
A
P
A
A
R
P
E
T
V
K
R
Y
A
S
L
Site 244
S2101
E
T
V
K
R
Y
A
S
L
P
H
I
S
V
A
Site 245
S2106
Y
A
S
L
P
H
I
S
V
A
R
R
P
D
G
Site 246
S2121
A
V
P
A
A
P
A
S
A
D
A
A
R
R
S
Site 247
S2128
S
A
D
A
A
R
R
S
S
D
G
E
P
R
P
Site 248
S2129
A
D
A
A
R
R
S
S
D
G
E
P
R
P
L
Site 249
T2144
P
R
V
A
A
P
G
T
T
W
R
R
I
R
D
Site 250
S2160
D
V
P
H
I
L
R
S
T
L
P
A
T
A
L
Site 251
T2161
V
P
H
I
L
R
S
T
L
P
A
T
A
L
P
Site 252
S2172
T
A
L
P
L
R
G
S
T
P
E
D
A
P
A
Site 253
T2173
A
L
P
L
R
G
S
T
P
E
D
A
P
A
G
Site 254
T2186
A
G
P
P
P
R
K
T
S
D
A
V
V
Q
T
Site 255
S2187
G
P
P
P
R
K
T
S
D
A
V
V
Q
T
E
Site 256
T2201
E
E
V
A
A
P
K
T
N
S
S
T
S
P
S
Site 257
S2203
V
A
A
P
K
T
N
S
S
T
S
P
S
L
E
Site 258
S2204
A
A
P
K
T
N
S
S
T
S
P
S
L
E
T
Site 259
T2205
A
P
K
T
N
S
S
T
S
P
S
L
E
T
R
Site 260
S2206
P
K
T
N
S
S
T
S
P
S
L
E
T
R
E
Site 261
S2208
T
N
S
S
T
S
P
S
L
E
T
R
E
P
P
Site 262
T2211
S
T
S
P
S
L
E
T
R
E
P
P
G
A
P
Site 263
S2234
G
S
D
V
D
G
P
S
L
A
K
A
P
I
S
Site 264
S2259
A
V
G
G
F
P
A
S
R
H
G
S
P
S
R
Site 265
S2263
F
P
A
S
R
H
G
S
P
S
R
S
A
R
V
Site 266
S2265
A
S
R
H
G
S
P
S
R
S
A
R
V
P
P
Site 267
S2267
R
H
G
S
P
S
R
S
A
R
V
P
P
F
N
Site 268
S2298
E
K
A
P
A
T
A
S
A
T
L
L
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation