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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TOP3B
Full Name:
DNA topoisomerase 3-beta-1
Alias:
DNA topoisomerase III beta-1
Type:
Mass (Da):
96662
Number AA:
862
UniProt ID:
O95985
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
E
K
P
S
L
A
Q
S
I
A
K
I
L
S
R
Site 2
S22
Q
S
I
A
K
I
L
S
R
G
S
L
S
S
H
Site 3
S25
A
K
I
L
S
R
G
S
L
S
S
H
K
G
L
Site 4
S27
I
L
S
R
G
S
L
S
S
H
K
G
L
N
G
Site 5
S28
L
S
R
G
S
L
S
S
H
K
G
L
N
G
A
Site 6
S37
K
G
L
N
G
A
C
S
V
H
E
Y
T
G
T
Site 7
Y41
G
A
C
S
V
H
E
Y
T
G
T
F
A
G
Q
Site 8
T44
S
V
H
E
Y
T
G
T
F
A
G
Q
P
V
R
Site 9
Y70
T
L
D
F
L
G
K
Y
N
K
W
D
K
V
D
Site 10
S83
V
D
P
A
E
L
F
S
Q
A
P
T
E
K
K
Site 11
T87
E
L
F
S
Q
A
P
T
E
K
K
E
A
N
P
Site 12
T146
K
A
H
G
G
E
K
T
V
F
R
A
R
F
S
Site 13
S153
T
V
F
R
A
R
F
S
S
I
T
D
T
D
I
Site 14
T156
R
A
R
F
S
S
I
T
D
T
D
I
C
N
A
Site 15
T158
R
F
S
S
I
T
D
T
D
I
C
N
A
M
A
Site 16
S177
P
D
H
N
E
A
L
S
V
D
A
R
Q
E
L
Site 17
Y199
F
T
R
F
Q
T
K
Y
F
Q
G
K
Y
G
D
Site 18
Y204
T
K
Y
F
Q
G
K
Y
G
D
L
D
S
S
L
Site 19
S209
G
K
Y
G
D
L
D
S
S
L
I
S
F
G
P
Site 20
S210
K
Y
G
D
L
D
S
S
L
I
S
F
G
P
C
Site 21
S213
D
L
D
S
S
L
I
S
F
G
P
C
Q
T
P
Site 22
S254
V
N
T
D
K
D
R
S
L
L
L
D
W
D
R
Site 23
S312
E
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
Site 24
S313
M
L
R
V
A
S
S
S
L
G
M
G
P
Q
H
Site 25
Y329
M
Q
T
A
E
R
L
Y
T
Q
G
Y
I
S
Y
Site 26
T330
Q
T
A
E
R
L
Y
T
Q
G
Y
I
S
Y
P
Site 27
Y333
E
R
L
Y
T
Q
G
Y
I
S
Y
P
R
T
E
Site 28
Y336
Y
T
Q
G
Y
I
S
Y
P
R
T
E
T
T
H
Site 29
T339
G
Y
I
S
Y
P
R
T
E
T
T
H
Y
P
E
Site 30
T341
I
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
Site 31
T342
S
Y
P
R
T
E
T
T
H
Y
P
E
N
F
D
Site 32
Y344
P
R
T
E
T
T
H
Y
P
E
N
F
D
L
K
Site 33
S353
E
N
F
D
L
K
G
S
L
R
Q
Q
A
N
H
Site 34
Y362
R
Q
Q
A
N
H
P
Y
W
A
D
T
V
K
R
Site 35
T366
N
H
P
Y
W
A
D
T
V
K
R
L
L
A
E
Site 36
T391
A
G
D
H
P
P
I
T
P
M
K
S
A
T
E
Site 37
S395
P
P
I
T
P
M
K
S
A
T
E
A
E
L
G
Site 38
Y409
G
G
D
A
W
R
L
Y
E
Y
I
T
R
H
F
Site 39
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Site 40
T419
I
T
R
H
F
I
A
T
V
S
H
D
C
K
Y
Site 41
Y426
T
V
S
H
D
C
K
Y
L
Q
S
T
I
S
F
Site 42
S432
K
Y
L
Q
S
T
I
S
F
R
I
G
P
E
L
Site 43
S460
T
E
V
M
P
W
Q
S
V
P
L
E
E
S
L
Site 44
S466
Q
S
V
P
L
E
E
S
L
P
T
C
Q
R
G
Site 45
T469
P
L
E
E
S
L
P
T
C
Q
R
G
D
A
F
Site 46
Y493
K
Q
T
N
P
P
D
Y
L
T
E
A
E
L
I
Site 47
T495
T
N
P
P
D
Y
L
T
E
A
E
L
I
T
L
Site 48
T501
L
T
E
A
E
L
I
T
L
M
E
K
H
G
I
Site 49
Y526
N
N
I
C
Q
R
N
Y
V
T
V
E
S
G
R
Site 50
S531
R
N
Y
V
T
V
E
S
G
R
R
L
K
P
T
Site 51
Y548
G
I
V
L
V
H
G
Y
Y
K
I
D
A
E
L
Site 52
Y578
I
A
Q
G
K
A
D
Y
R
Q
V
L
G
H
T
Site 53
T617
S
F
S
P
L
A
A
T
G
K
P
L
S
R
C
Site 54
S622
A
A
T
G
K
P
L
S
R
C
G
K
C
H
R
Site 55
Y633
K
C
H
R
F
M
K
Y
I
Q
A
K
P
S
R
Site 56
Y650
C
S
H
C
D
E
T
Y
T
L
P
Q
N
G
T
Site 57
Y661
Q
N
G
T
I
K
L
Y
K
E
L
R
C
P
L
Site 58
S677
D
F
E
L
V
L
W
S
S
G
S
R
G
K
S
Site 59
S678
F
E
L
V
L
W
S
S
G
S
R
G
K
S
Y
Site 60
S680
L
V
L
W
S
S
G
S
R
G
K
S
Y
P
L
Site 61
S684
S
S
G
S
R
G
K
S
Y
P
L
C
P
Y
C
Site 62
Y685
S
G
S
R
G
K
S
Y
P
L
C
P
Y
C
Y
Site 63
S717
T
H
P
S
C
Q
H
S
L
S
M
L
G
I
G
Site 64
S767
N
A
H
R
V
R
V
S
A
D
T
C
S
V
C
Site 65
S788
V
D
F
N
K
A
K
S
P
L
P
G
D
E
T
Site 66
T795
S
P
L
P
G
D
E
T
Q
H
M
G
C
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation