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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RECK
Full Name:
Reversion-inducing cysteine-rich protein with Kazal motifs
Alias:
hRECK; reversion-inducing cysteine-rich protein with Kazal motifs; reversion-inducing-cysteine-rich protein with kazal motifs; ST15; suppressor of tumorigenicity 15
Type:
Mass (Da):
106460
Number AA:
UniProt ID:
O95980
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0000300
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008191
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S56
D
V
C
E
Q
I
F
S
S
K
S
E
S
R
L
Site 2
S57
V
C
E
Q
I
F
S
S
K
S
E
S
R
L
K
Site 3
S59
E
Q
I
F
S
S
K
S
E
S
R
L
K
H
L
Site 4
S61
I
F
S
S
K
S
E
S
R
L
K
H
L
L
Q
Site 5
Y73
L
L
Q
R
A
P
D
Y
C
P
E
T
M
V
E
Site 6
S127
A
S
S
K
N
D
I
S
K
V
C
R
K
E
Y
Site 7
Y134
S
K
V
C
R
K
E
Y
E
N
A
L
F
S
C
Site 8
S149
I
S
R
N
E
M
G
S
V
C
C
S
Y
A
G
Site 9
Y154
M
G
S
V
C
C
S
Y
A
G
H
H
T
N
C
Site 10
Y164
H
H
T
N
C
R
E
Y
C
Q
A
I
F
R
T
Site 11
S173
Q
A
I
F
R
T
D
S
S
P
G
P
S
Q
I
Site 12
S174
A
I
F
R
T
D
S
S
P
G
P
S
Q
I
K
Site 13
S178
T
D
S
S
P
G
P
S
Q
I
K
A
V
E
N
Site 14
Y186
Q
I
K
A
V
E
N
Y
C
A
S
I
S
P
Q
Site 15
Y201
L
I
H
C
V
N
N
Y
T
Q
S
Y
P
M
R
Site 16
Y205
V
N
N
Y
T
Q
S
Y
P
M
R
N
P
T
D
Site 17
Y215
R
N
P
T
D
S
L
Y
C
C
D
R
A
E
D
Site 18
T238
R
I
L
M
S
K
K
T
E
M
E
I
V
D
G
Site 19
T252
G
L
I
E
G
C
K
T
Q
P
L
P
Q
D
P
Site 20
S268
W
Q
C
F
L
E
S
S
Q
S
V
H
P
G
V
Site 21
T276
Q
S
V
H
P
G
V
T
V
H
P
P
P
S
T
Site 22
S282
V
T
V
H
P
P
P
S
T
G
L
D
G
A
K
Site 23
T298
H
C
C
S
K
A
N
T
S
T
C
R
E
L
C
Site 24
T300
C
S
K
A
N
T
S
T
C
R
E
L
C
T
K
Site 25
Y309
R
E
L
C
T
K
L
Y
S
M
S
W
G
N
T
Site 26
Y328
E
F
D
R
F
C
E
Y
N
P
V
E
V
S
M
Site 27
Y355
L
G
C
R
N
L
T
Y
C
T
N
F
N
N
R
Site 28
T364
T
N
F
N
N
R
P
T
E
L
F
R
S
C
N
Site 29
S369
R
P
T
E
L
F
R
S
C
N
A
Q
S
D
Q
Site 30
S424
L
Q
I
K
P
C
H
S
K
S
R
G
S
I
I
Site 31
S426
I
K
P
C
H
S
K
S
R
G
S
I
I
C
K
Site 32
S429
C
H
S
K
S
R
G
S
I
I
C
K
S
D
C
Site 33
T454
N
K
F
P
E
D
H
T
A
E
S
I
C
E
L
Site 34
S457
P
E
D
H
T
A
E
S
I
C
E
L
L
S
P
Site 35
S463
E
S
I
C
E
L
L
S
P
T
D
D
L
K
N
Site 36
T476
K
N
C
I
P
L
D
T
Y
L
R
P
S
T
L
Site 37
Y477
N
C
I
P
L
D
T
Y
L
R
P
S
T
L
G
Site 38
S481
L
D
T
Y
L
R
P
S
T
L
G
N
I
V
E
Site 39
T482
D
T
Y
L
R
P
S
T
L
G
N
I
V
E
E
Site 40
S514
V
N
R
K
G
C
P
S
G
D
P
C
L
P
Y
Site 41
Y521
S
G
D
P
C
L
P
Y
F
C
V
Q
G
C
K
Site 42
S589
I
V
G
G
K
R
K
S
H
G
T
S
F
S
I
Site 43
T592
G
K
R
K
S
H
G
T
S
F
S
I
D
C
N
Site 44
S593
K
R
K
S
H
G
T
S
F
S
I
D
C
N
V
Site 45
S595
K
S
H
G
T
S
F
S
I
D
C
N
V
C
S
Site 46
S617
C
S
T
R
L
C
L
S
E
H
S
S
E
D
D
Site 47
S621
L
C
L
S
E
H
S
S
E
D
D
R
R
T
F
Site 48
T627
S
S
E
D
D
R
R
T
F
T
G
L
P
C
N
Site 49
T629
E
D
D
R
R
T
F
T
G
L
P
C
N
C
A
Site 50
Y650
C
G
Q
N
G
R
T
Y
P
S
A
C
I
A
R
Site 51
T697
P
K
P
Q
V
C
L
T
T
F
D
K
F
G
C
Site 52
T698
K
P
Q
V
C
L
T
T
F
D
K
F
G
C
S
Site 53
Y707
D
K
F
G
C
S
Q
Y
E
C
V
P
R
Q
L
Site 54
Y738
H
N
N
L
C
T
L
Y
Q
R
G
K
S
L
S
Site 55
S743
T
L
Y
Q
R
G
K
S
L
S
Y
K
G
P
C
Site 56
S745
Y
Q
R
G
K
S
L
S
Y
K
G
P
C
Q
P
Site 57
Y746
Q
R
G
K
S
L
S
Y
K
G
P
C
Q
P
F
Site 58
Y768
C
G
H
N
G
E
T
Y
S
S
V
C
A
A
Y
Site 59
S769
G
H
N
G
E
T
Y
S
S
V
C
A
A
Y
S
Site 60
S770
H
N
G
E
T
Y
S
S
V
C
A
A
Y
S
D
Site 61
Y783
S
D
R
V
A
V
D
Y
Y
G
D
C
Q
A
V
Site 62
Y784
D
R
V
A
V
D
Y
Y
G
D
C
Q
A
V
G
Site 63
T843
F
D
K
E
K
L
D
T
I
A
K
V
T
N
K
Site 64
T848
L
D
T
I
A
K
V
T
N
K
K
P
I
T
V
Site 65
T854
V
T
N
K
K
P
I
T
V
L
E
I
L
Q
K
Site 66
S911
K
E
A
E
K
I
E
S
L
I
N
S
D
S
P
Site 67
S915
K
I
E
S
L
I
N
S
D
S
P
T
L
A
S
Site 68
S917
E
S
L
I
N
S
D
S
P
T
L
A
S
H
V
Site 69
S939
S
Q
V
Q
V
S
S
S
V
P
S
A
G
V
R
Site 70
S942
Q
V
S
S
S
V
P
S
A
G
V
R
A
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation