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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGI1
Full Name:
Leucine-rich glioma-inactivated protein 1
Alias:
Epitempin-1
Type:
Mass (Da):
63818
Number AA:
557
UniProt ID:
O95970
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Leucine-rich glioma-inactivated protein 1 pan-specific antibody AB-NN249-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN249-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
I
P
L
K
R
I
A
Y
F
L
C
L
L
S
A
Site 2
S27
A
Y
F
L
C
L
L
S
A
L
L
L
T
E
G
Site 3
T32
L
L
S
A
L
L
L
T
E
G
K
K
P
A
K
Site 4
S60
A
L
C
E
N
A
R
S
I
P
R
T
V
P
P
Site 5
T64
N
A
R
S
I
P
R
T
V
P
P
D
V
I
S
Site 6
S83
R
S
G
F
T
E
I
S
E
G
S
F
L
F
T
Site 7
Y119
I
G
L
P
H
L
E
Y
L
F
I
E
N
N
N
Site 8
T134
I
K
S
I
S
R
H
T
F
R
G
L
K
S
L
Site 9
S164
D
I
F
K
G
L
D
S
L
T
N
V
D
L
R
Site 10
T166
F
K
G
L
D
S
L
T
N
V
D
L
R
G
N
Site 11
T194
W
L
G
H
T
N
A
T
V
E
D
I
Y
C
E
Site 12
Y199
N
A
T
V
E
D
I
Y
C
E
G
P
P
E
Y
Site 13
Y206
Y
C
E
G
P
P
E
Y
K
K
R
K
I
N
S
Site 14
S213
Y
K
K
R
K
I
N
S
L
S
S
K
D
F
D
Site 15
S215
K
R
K
I
N
S
L
S
S
K
D
F
D
C
I
Site 16
S229
I
I
T
E
F
A
K
S
Q
D
L
P
Y
Q
S
Site 17
Y234
A
K
S
Q
D
L
P
Y
Q
S
L
S
I
D
T
Site 18
S236
S
Q
D
L
P
Y
Q
S
L
S
I
D
T
F
S
Site 19
S238
D
L
P
Y
Q
S
L
S
I
D
T
F
S
Y
L
Site 20
T241
Y
Q
S
L
S
I
D
T
F
S
Y
L
N
D
E
Site 21
S243
S
L
S
I
D
T
F
S
Y
L
N
D
E
Y
V
Site 22
Y275
V
E
K
T
F
R
N
Y
D
N
I
T
G
T
S
Site 23
Y309
L
F
G
G
S
H
I
Y
K
R
D
S
F
A
N
Site 24
S313
S
H
I
Y
K
R
D
S
F
A
N
K
F
I
K
Site 25
T337
R
K
P
N
D
I
E
T
F
K
I
E
N
N
W
Site 26
Y345
F
K
I
E
N
N
W
Y
F
V
V
A
D
S
S
Site 27
Y360
K
A
G
F
T
T
I
Y
K
W
N
G
N
G
F
Site 28
Y368
K
W
N
G
N
G
F
Y
S
H
Q
S
L
H
A
Site 29
Y384
Y
R
D
T
D
V
E
Y
L
E
I
V
R
T
P
Site 30
T390
E
Y
L
E
I
V
R
T
P
Q
T
L
R
T
P
Site 31
T393
E
I
V
R
T
P
Q
T
L
R
T
P
H
L
I
Site 32
T396
R
T
P
Q
T
L
R
T
P
H
L
I
L
S
S
Site 33
S402
R
T
P
H
L
I
L
S
S
S
S
Q
R
P
V
Site 34
S403
T
P
H
L
I
L
S
S
S
S
Q
R
P
V
I
Site 35
S404
P
H
L
I
L
S
S
S
S
Q
R
P
V
I
Y
Site 36
S405
H
L
I
L
S
S
S
S
Q
R
P
V
I
Y
Q
Site 37
Y411
S
S
Q
R
P
V
I
Y
Q
W
N
K
A
T
Q
Site 38
T424
T
Q
L
F
T
N
Q
T
D
I
P
N
M
E
D
Site 39
S473
Q
D
I
Q
R
M
P
S
R
G
S
M
V
F
Q
Site 40
S476
Q
R
M
P
S
R
G
S
M
V
F
Q
P
L
Q
Site 41
Y487
Q
P
L
Q
I
N
N
Y
Q
Y
A
I
L
G
S
Site 42
Y489
L
Q
I
N
N
Y
Q
Y
A
I
L
G
S
D
Y
Site 43
S494
Y
Q
Y
A
I
L
G
S
D
Y
S
F
T
Q
V
Site 44
Y496
Y
A
I
L
G
S
D
Y
S
F
T
Q
V
Y
N
Site 45
S524
L
N
V
Q
A
P
R
S
F
T
H
V
S
I
N
Site 46
T526
V
Q
A
P
R
S
F
T
H
V
S
I
N
K
R
Site 47
S540
R
N
F
L
F
A
S
S
F
K
G
N
T
Q
I
Site 48
Y548
F
K
G
N
T
Q
I
Y
K
H
V
I
V
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation