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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX58
Full Name:
Probable ATP-dependent RNA helicase DDX58
Alias:
DEAD box protein 58;Retinoic acid-inducible gene 1 protein;Retinoic acid-inducible gene I protein
Type:
Mass (Da):
106600
Number AA:
925
UniProt ID:
O95786
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
T
T
E
Q
R
R
S
L
Q
A
F
Q
D
Y
Site 2
Y15
S
L
Q
A
F
Q
D
Y
I
R
K
T
L
D
P
Site 3
T19
F
Q
D
Y
I
R
K
T
L
D
P
T
Y
I
L
Site 4
Y24
R
K
T
L
D
P
T
Y
I
L
S
Y
M
A
P
Site 5
Y28
D
P
T
Y
I
L
S
Y
M
A
P
W
F
R
E
Site 6
Y40
F
R
E
E
E
V
Q
Y
I
Q
A
E
K
N
N
Site 7
Y86
H
A
G
Y
S
G
L
Y
E
A
I
E
S
W
D
Site 8
S91
G
L
Y
E
A
I
E
S
W
D
F
K
K
I
E
Site 9
S128
T
D
I
I
S
D
L
S
E
C
L
I
N
Q
E
Site 10
S162
L
V
E
C
L
L
R
S
D
K
E
N
W
P
K
Site 11
T170
D
K
E
N
W
P
K
T
L
K
L
A
L
E
K
Site 12
T197
K
G
I
K
D
V
E
T
E
D
L
E
D
K
M
Site 13
Y213
T
S
D
I
Q
I
F
Y
Q
E
D
P
E
C
Q
Site 14
S223
D
P
E
C
Q
N
L
S
E
N
S
C
P
P
S
Site 15
S226
C
Q
N
L
S
E
N
S
C
P
P
S
E
V
S
Site 16
S230
S
E
N
S
C
P
P
S
E
V
S
D
T
N
L
Site 17
S233
S
C
P
P
S
E
V
S
D
T
N
L
Y
S
P
Site 18
T235
P
P
S
E
V
S
D
T
N
L
Y
S
P
F
K
Site 19
Y238
E
V
S
D
T
N
L
Y
S
P
F
K
P
R
N
Site 20
S239
V
S
D
T
N
L
Y
S
P
F
K
P
R
N
Y
Site 21
Y246
S
P
F
K
P
R
N
Y
Q
L
E
L
A
L
P
Site 22
Y303
F
A
N
Q
I
P
V
Y
E
Q
Q
K
S
V
F
Site 23
S308
P
V
Y
E
Q
Q
K
S
V
F
S
K
Y
F
E
Site 24
Y313
Q
K
S
V
F
S
K
Y
F
E
R
H
G
Y
R
Site 25
Y319
K
Y
F
E
R
H
G
Y
R
V
T
G
I
S
G
Site 26
T322
E
R
H
G
Y
R
V
T
G
I
S
G
A
T
A
Site 27
S325
G
Y
R
V
T
G
I
S
G
A
T
A
E
N
V
Site 28
Y390
Y
N
M
I
M
F
N
Y
L
D
Q
K
L
G
G
Site 29
Y426
N
T
D
E
A
L
D
Y
I
C
K
L
C
A
S
Site 30
Y454
E
E
L
E
Q
V
V
Y
K
P
Q
K
F
F
R
Site 31
S468
R
K
V
E
S
R
I
S
D
K
F
K
Y
I
I
Site 32
Y473
R
I
S
D
K
F
K
Y
I
I
A
Q
L
M
R
Site 33
T482
I
A
Q
L
M
R
D
T
E
S
L
A
K
R
I
Site 34
S484
Q
L
M
R
D
T
E
S
L
A
K
R
I
C
K
Site 35
S497
C
K
D
L
E
N
L
S
Q
I
Q
N
R
E
F
Site 36
Y509
R
E
F
G
T
Q
K
Y
E
Q
W
I
V
T
V
Site 37
S543
K
A
L
F
L
Y
T
S
H
L
R
K
Y
N
D
Site 38
Y548
Y
T
S
H
L
R
K
Y
N
D
A
L
I
I
S
Site 39
Y566
R
M
K
D
A
L
D
Y
L
K
D
F
F
S
N
Site 40
S572
D
Y
L
K
D
F
F
S
N
V
R
A
A
G
F
Site 41
T587
D
E
I
E
Q
D
L
T
Q
R
F
E
E
K
L
Site 42
S599
E
K
L
Q
E
L
E
S
V
S
R
D
P
S
N
Site 43
S601
L
Q
E
L
E
S
V
S
R
D
P
S
N
E
N
Site 44
S605
E
S
V
S
R
D
P
S
N
E
N
P
K
L
E
Site 45
T662
F
L
K
P
G
I
L
T
G
R
G
K
T
N
Q
Site 46
T667
I
L
T
G
R
G
K
T
N
Q
N
T
G
M
T
Site 47
S736
G
R
G
R
A
R
G
S
K
C
F
L
L
T
S
Site 48
Y756
E
K
E
Q
I
N
M
Y
K
E
K
M
M
N
D
Site 49
T770
D
S
I
L
R
L
Q
T
W
D
E
A
V
F
R
Site 50
S793
H
E
K
F
I
R
D
S
Q
E
K
P
K
P
V
Site 51
Y831
R
V
I
E
E
C
H
Y
T
V
L
G
D
A
F
Site 52
S844
A
F
K
E
C
F
V
S
R
P
H
P
K
P
K
Site 53
S854
H
P
K
P
K
Q
F
S
S
F
E
K
R
A
K
Site 54
S855
P
K
P
K
Q
F
S
S
F
E
K
R
A
K
I
Site 55
Y879
D
W
G
I
H
V
K
Y
K
T
F
E
I
P
V
Site 56
Y905
A
T
G
V
Q
T
L
Y
S
K
W
K
D
F
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation