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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GGPS1
Full Name:
Geranylgeranyl pyrophosphate synthase
Alias:
EC 2.5.1.1; EC 2.5.1.10; EC 2.5.1.29; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranylgeranyl diphosphate synthase 1; Geranyltranstransferase; GGPP synthetase; GGPPS; GGPPS1; GGPPSase
Type:
EC 2.5.1.10; EC 2.5.1.29; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1; Transferase
Mass (Da):
34871
Number AA:
300
UniProt ID:
O95749
International Prot ID:
IPI00032892
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0004161
GO:0004311
GO:0004337
PhosphoSite+
KinaseNET
Biological Process:
GO:0008299
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
K
T
Q
E
T
V
Q
R
I
L
L
E
Site 2
Y16
Q
R
I
L
L
E
P
Y
K
Y
L
L
Q
L
P
Site 3
Y18
I
L
L
E
P
Y
K
Y
L
L
Q
L
P
G
K
Site 4
S32
K
Q
V
R
T
K
L
S
Q
A
F
N
H
W
L
Site 5
S60
T
E
M
L
H
N
A
S
L
L
I
D
D
I
E
Site 6
S70
I
D
D
I
E
D
N
S
K
L
R
R
G
F
P
Site 7
S81
R
G
F
P
V
A
H
S
I
Y
G
I
P
S
V
Site 8
S87
H
S
I
Y
G
I
P
S
V
I
N
S
A
N
Y
Site 9
S91
G
I
P
S
V
I
N
S
A
N
Y
V
Y
F
L
Site 10
Y94
S
V
I
N
S
A
N
Y
V
Y
F
L
G
L
E
Site 11
Y131
Q
G
Q
G
L
D
I
Y
W
R
D
N
Y
T
C
Site 12
Y136
D
I
Y
W
R
D
N
Y
T
C
P
T
E
E
E
Site 13
S167
V
G
L
M
Q
L
F
S
D
Y
K
E
D
L
K
Site 14
Y169
L
M
Q
L
F
S
D
Y
K
E
D
L
K
P
L
Site 15
Y190
F
F
Q
I
R
D
D
Y
A
N
L
H
S
K
E
Site 16
S195
D
D
Y
A
N
L
H
S
K
E
Y
S
E
N
K
Site 17
Y198
A
N
L
H
S
K
E
Y
S
E
N
K
S
F
C
Site 18
S199
N
L
H
S
K
E
Y
S
E
N
K
S
F
C
E
Site 19
S203
K
E
Y
S
E
N
K
S
F
C
E
D
L
T
E
Site 20
T209
K
S
F
C
E
D
L
T
E
G
K
F
S
F
P
Site 21
T217
E
G
K
F
S
F
P
T
I
H
A
I
W
S
R
Site 22
S223
P
T
I
H
A
I
W
S
R
P
E
S
T
Q
V
Site 23
S227
A
I
W
S
R
P
E
S
T
Q
V
Q
N
I
L
Site 24
T238
Q
N
I
L
R
Q
R
T
E
N
I
D
I
K
K
Site 25
Y246
E
N
I
D
I
K
K
Y
C
V
H
Y
L
E
D
Site 26
Y250
I
K
K
Y
C
V
H
Y
L
E
D
V
G
S
F
Site 27
S256
H
Y
L
E
D
V
G
S
F
E
Y
T
R
N
T
Site 28
Y259
E
D
V
G
S
F
E
Y
T
R
N
T
L
K
E
Site 29
T260
D
V
G
S
F
E
Y
T
R
N
T
L
K
E
L
Site 30
T263
S
F
E
Y
T
R
N
T
L
K
E
L
E
A
K
Site 31
Y272
K
E
L
E
A
K
A
Y
K
Q
I
D
A
R
G
Site 32
S292
V
A
L
V
K
H
L
S
K
M
F
K
E
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation