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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BRD1
Full Name:
Bromodomain-containing protein 1
Alias:
BR140-like; BR140-like protein; BRL; Bromodomain containing 1; BRPF1; BRPF2
Type:
Cell development/differentiation
Mass (Da):
119520
Number AA:
1058
UniProt ID:
O95696
International Prot ID:
IPI00032214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070776
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0043966
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
G
R
C
H
R
G
S
A
A
R
H
P
S
S
Site 2
S17
G
S
A
A
R
H
P
S
S
P
C
S
V
K
H
Site 3
S18
S
A
A
R
H
P
S
S
P
C
S
V
K
H
S
Site 4
S21
R
H
P
S
S
P
C
S
V
K
H
S
P
T
R
Site 5
S25
S
P
C
S
V
K
H
S
P
T
R
E
T
L
T
Site 6
T27
C
S
V
K
H
S
P
T
R
E
T
L
T
Y
A
Site 7
T30
K
H
S
P
T
R
E
T
L
T
Y
A
Q
A
Q
Site 8
T32
S
P
T
R
E
T
L
T
Y
A
Q
A
Q
R
M
Site 9
Y33
P
T
R
E
T
L
T
Y
A
Q
A
Q
R
M
V
Site 10
S52
E
G
R
L
H
R
I
S
I
F
D
P
L
E
I
Site 11
T66
I
I
L
E
D
D
L
T
A
Q
E
M
S
E
C
Site 12
S75
Q
E
M
S
E
C
N
S
N
K
E
N
S
E
R
Site 13
S80
C
N
S
N
K
E
N
S
E
R
P
P
V
C
L
Site 14
T89
R
P
P
V
C
L
R
T
K
R
H
K
N
N
R
Site 15
S106
K
K
N
E
A
L
P
S
A
H
G
T
P
A
S
Site 16
S113
S
A
H
G
T
P
A
S
A
S
A
L
P
E
P
Site 17
S115
H
G
T
P
A
S
A
S
A
L
P
E
P
K
V
Site 18
Y127
P
K
V
R
I
V
E
Y
S
P
P
S
A
P
R
Site 19
S128
K
V
R
I
V
E
Y
S
P
P
S
A
P
R
R
Site 20
S131
I
V
E
Y
S
P
P
S
A
P
R
R
P
P
V
Site 21
Y139
A
P
R
R
P
P
V
Y
Y
K
F
I
E
K
S
Site 22
Y140
P
R
R
P
P
V
Y
Y
K
F
I
E
K
S
A
Site 23
S146
Y
Y
K
F
I
E
K
S
A
E
E
L
D
N
E
Site 24
Y156
E
L
D
N
E
V
E
Y
D
M
D
E
E
D
Y
Site 25
Y163
Y
D
M
D
E
E
D
Y
A
W
L
E
I
V
N
Site 26
S209
Q
K
Q
G
E
Q
Q
S
L
I
D
E
D
A
V
Site 27
Y250
Q
E
C
Y
G
V
P
Y
I
P
E
G
Q
W
L
Site 28
T284
K
G
G
A
F
K
K
T
D
D
D
R
W
G
H
Site 29
Y328
A
R
W
K
L
T
C
Y
L
C
K
Q
K
G
V
Site 30
Y361
C
A
Q
K
A
G
L
Y
M
K
M
E
P
V
K
Site 31
T376
E
L
T
G
G
G
T
T
F
S
V
R
K
T
A
Site 32
S378
T
G
G
G
T
T
F
S
V
R
K
T
A
Y
C
Site 33
T382
T
T
F
S
V
R
K
T
A
Y
C
D
V
H
T
Site 34
Y384
F
S
V
R
K
T
A
Y
C
D
V
H
T
P
P
Site 35
T389
T
A
Y
C
D
V
H
T
P
P
G
C
T
R
R
Site 36
Y401
T
R
R
P
L
N
I
Y
G
D
V
E
M
K
N
Site 37
S415
N
G
V
C
R
K
E
S
S
V
K
T
V
R
S
Site 38
S416
G
V
C
R
K
E
S
S
V
K
T
V
R
S
T
Site 39
T419
R
K
E
S
S
V
K
T
V
R
S
T
S
K
V
Site 40
S422
S
S
V
K
T
V
R
S
T
S
K
V
R
K
K
Site 41
T423
S
V
K
T
V
R
S
T
S
K
V
R
K
K
A
Site 42
S424
V
K
T
V
R
S
T
S
K
V
R
K
K
A
K
Site 43
S478
Q
F
V
E
R
A
H
S
Y
W
L
L
K
R
L
Site 44
S486
Y
W
L
L
K
R
L
S
R
N
G
A
P
L
L
Site 45
S498
P
L
L
R
R
L
Q
S
S
L
Q
S
Q
R
S
Site 46
S499
L
L
R
R
L
Q
S
S
L
Q
S
Q
R
S
S
Site 47
S502
R
L
Q
S
S
L
Q
S
Q
R
S
S
Q
Q
R
Site 48
S505
S
S
L
Q
S
Q
R
S
S
Q
Q
R
E
N
D
Site 49
S506
S
L
Q
S
Q
R
S
S
Q
Q
R
E
N
D
E
Site 50
Y524
A
A
K
E
K
L
K
Y
W
Q
R
L
R
H
D
Site 51
S592
R
I
F
A
Q
P
V
S
L
K
E
V
P
D
Y
Site 52
Y599
S
L
K
E
V
P
D
Y
L
D
H
I
K
H
P
Site 53
T611
K
H
P
M
D
F
A
T
M
R
K
R
L
E
A
Site 54
Y621
K
R
L
E
A
Q
G
Y
K
N
L
H
E
F
E
Site 55
Y641
I
I
D
N
C
M
K
Y
N
A
R
D
T
V
F
Site 56
T646
M
K
Y
N
A
R
D
T
V
F
Y
R
A
A
V
Site 57
Y649
N
A
R
D
T
V
F
Y
R
A
A
V
R
L
R
Site 58
S672
Q
A
R
R
E
V
D
S
I
G
L
E
E
A
S
Site 59
S679
S
I
G
L
E
E
A
S
G
M
H
L
P
E
R
Site 60
S696
A
A
P
R
R
P
F
S
W
E
D
V
D
R
L
Site 61
S733
D
L
T
C
A
M
K
S
S
G
S
R
S
K
R
Site 62
S734
L
T
C
A
M
K
S
S
G
S
R
S
K
R
A
Site 63
S738
M
K
S
S
G
S
R
S
K
R
A
K
L
L
K
Site 64
S756
A
L
L
R
N
K
L
S
Q
Q
H
S
Q
P
L
Site 65
S760
N
K
L
S
Q
Q
H
S
Q
P
L
P
T
G
P
Site 66
T793
E
V
L
P
R
L
E
T
L
L
Q
P
R
K
R
Site 67
S801
L
L
Q
P
R
K
R
S
R
S
T
C
G
D
S
Site 68
S803
Q
P
R
K
R
S
R
S
T
C
G
D
S
E
V
Site 69
T804
P
R
K
R
S
R
S
T
C
G
D
S
E
V
E
Site 70
S808
S
R
S
T
C
G
D
S
E
V
E
E
E
S
P
Site 71
S814
D
S
E
V
E
E
E
S
P
G
K
R
L
D
A
Site 72
T824
K
R
L
D
A
G
L
T
N
G
F
G
G
A
R
Site 73
S832
N
G
F
G
G
A
R
S
E
Q
E
P
G
G
G
Site 74
T845
G
G
L
G
R
K
A
T
P
R
R
R
C
A
S
Site 75
S852
T
P
R
R
R
C
A
S
E
S
S
I
S
S
S
Site 76
S854
R
R
R
C
A
S
E
S
S
I
S
S
S
N
S
Site 77
S855
R
R
C
A
S
E
S
S
I
S
S
S
N
S
P
Site 78
S857
C
A
S
E
S
S
I
S
S
S
N
S
P
L
C
Site 79
S858
A
S
E
S
S
I
S
S
S
N
S
P
L
C
D
Site 80
S859
S
E
S
S
I
S
S
S
N
S
P
L
C
D
S
Site 81
S861
S
S
I
S
S
S
N
S
P
L
C
D
S
S
F
Site 82
S866
S
N
S
P
L
C
D
S
S
F
N
A
P
K
C
Site 83
S867
N
S
P
L
C
D
S
S
F
N
A
P
K
C
G
Site 84
T885
P
A
L
V
R
R
H
T
L
E
D
R
S
E
L
Site 85
S890
R
H
T
L
E
D
R
S
E
L
I
S
C
I
E
Site 86
S894
E
D
R
S
E
L
I
S
C
I
E
N
G
N
Y
Site 87
Y901
S
C
I
E
N
G
N
Y
A
K
A
A
R
I
A
Site 88
S915
A
A
E
V
G
Q
S
S
M
W
I
S
T
D
A
Site 89
Y943
K
C
S
G
Y
P
S
Y
P
A
L
I
I
D
P
Site 90
T963
P
G
H
H
N
G
V
T
I
P
A
P
P
L
D
Site 91
T980
K
I
G
E
H
M
Q
T
K
S
D
E
K
L
F
Site 92
S982
G
E
H
M
Q
T
K
S
D
E
K
L
F
L
V
Site 93
S1026
K
M
M
E
G
R
N
S
S
I
R
K
A
V
R
Site 94
S1027
M
M
E
G
R
N
S
S
I
R
K
A
V
R
I
Site 95
S1044
D
R
A
M
N
H
L
S
R
V
H
G
E
P
T
Site 96
T1051
S
R
V
H
G
E
P
T
S
D
L
S
D
I
D
Site 97
S1052
R
V
H
G
E
P
T
S
D
L
S
D
I
D
_
Site 98
S1055
G
E
P
T
S
D
L
S
D
I
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation