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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EYA4
Full Name:
Eyes absent homolog 4
Alias:
CMD1J; DFNA10; EC 3.1.3.48; Eyes absent 4
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
69505
Number AA:
639
UniProt ID:
O95677
International Prot ID:
IPI00219973
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0004725
GO:0004721
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0009653
GO:0016568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
D
S
Q
D
L
N
E
Q
S
Site 2
S11
S
Q
D
L
N
E
Q
S
V
K
K
T
C
T
E
Site 3
T15
N
E
Q
S
V
K
K
T
C
T
E
S
D
V
S
Site 4
T17
Q
S
V
K
K
T
C
T
E
S
D
V
S
Q
S
Site 5
S19
V
K
K
T
C
T
E
S
D
V
S
Q
S
Q
N
Site 6
S22
T
C
T
E
S
D
V
S
Q
S
Q
N
S
R
S
Site 7
S24
T
E
S
D
V
S
Q
S
Q
N
S
R
S
M
E
Site 8
S29
S
Q
S
Q
N
S
R
S
M
E
M
Q
D
L
A
Site 9
S37
M
E
M
Q
D
L
A
S
P
H
T
L
V
G
G
Site 10
T40
Q
D
L
A
S
P
H
T
L
V
G
G
G
D
T
Site 11
T47
T
L
V
G
G
G
D
T
P
G
S
S
K
L
E
Site 12
S50
G
G
G
D
T
P
G
S
S
K
L
E
K
S
N
Site 13
S51
G
G
D
T
P
G
S
S
K
L
E
K
S
N
L
Site 14
S56
G
S
S
K
L
E
K
S
N
L
S
S
T
S
V
Site 15
S59
K
L
E
K
S
N
L
S
S
T
S
V
T
T
N
Site 16
S60
L
E
K
S
N
L
S
S
T
S
V
T
T
N
G
Site 17
S62
K
S
N
L
S
S
T
S
V
T
T
N
G
T
G
Site 18
T64
N
L
S
S
T
S
V
T
T
N
G
T
G
G
E
Site 19
T74
G
T
G
G
E
N
M
T
V
L
N
T
A
D
W
Site 20
S84
N
T
A
D
W
L
L
S
C
N
T
P
S
S
A
Site 21
T87
D
W
L
L
S
C
N
T
P
S
S
A
T
M
S
Site 22
T100
M
S
L
L
A
V
K
T
E
P
L
N
S
S
E
Site 23
T111
N
S
S
E
T
T
A
T
T
G
D
G
A
L
D
Site 24
S127
F
T
G
S
V
I
T
S
S
G
Y
S
P
R
S
Site 25
S128
T
G
S
V
I
T
S
S
G
Y
S
P
R
S
A
Site 26
Y130
S
V
I
T
S
S
G
Y
S
P
R
S
A
H
Q
Site 27
S131
V
I
T
S
S
G
Y
S
P
R
S
A
H
Q
Y
Site 28
S134
S
S
G
Y
S
P
R
S
A
H
Q
Y
S
P
Q
Site 29
Y138
S
P
R
S
A
H
Q
Y
S
P
Q
L
Y
P
S
Site 30
S139
P
R
S
A
H
Q
Y
S
P
Q
L
Y
P
S
K
Site 31
Y143
H
Q
Y
S
P
Q
L
Y
P
S
K
P
Y
P
H
Site 32
S145
Y
S
P
Q
L
Y
P
S
K
P
Y
P
H
I
L
Site 33
Y148
Q
L
Y
P
S
K
P
Y
P
H
I
L
S
T
P
Site 34
S153
K
P
Y
P
H
I
L
S
T
P
A
A
Q
T
M
Site 35
T154
P
Y
P
H
I
L
S
T
P
A
A
Q
T
M
S
Site 36
Y178
G
M
Q
Q
P
A
V
Y
T
A
Y
S
Q
T
G
Site 37
S182
P
A
V
Y
T
A
Y
S
Q
T
G
Q
P
Y
S
Site 38
Y188
Y
S
Q
T
G
Q
P
Y
S
L
P
T
Y
D
L
Site 39
S189
S
Q
T
G
Q
P
Y
S
L
P
T
Y
D
L
G
Site 40
Y193
Q
P
Y
S
L
P
T
Y
D
L
G
V
M
L
P
Site 41
S209
I
K
T
E
S
G
L
S
Q
T
Q
S
P
L
Q
Site 42
T211
T
E
S
G
L
S
Q
T
Q
S
P
L
Q
S
G
Site 43
S213
S
G
L
S
Q
T
Q
S
P
L
Q
S
G
C
L
Site 44
S217
Q
T
Q
S
P
L
Q
S
G
C
L
S
Y
S
P
Site 45
S221
P
L
Q
S
G
C
L
S
Y
S
P
G
F
S
T
Site 46
S223
Q
S
G
C
L
S
Y
S
P
G
F
S
T
P
Q
Site 47
S227
L
S
Y
S
P
G
F
S
T
P
Q
P
G
Q
T
Site 48
T228
S
Y
S
P
G
F
S
T
P
Q
P
G
Q
T
P
Site 49
T234
S
T
P
Q
P
G
Q
T
P
Y
S
Y
Q
M
P
Site 50
Y236
P
Q
P
G
Q
T
P
Y
S
Y
Q
M
P
G
S
Site 51
S237
Q
P
G
Q
T
P
Y
S
Y
Q
M
P
G
S
S
Site 52
Y238
P
G
Q
T
P
Y
S
Y
Q
M
P
G
S
S
F
Site 53
S243
Y
S
Y
Q
M
P
G
S
S
F
A
P
S
S
T
Site 54
S244
S
Y
Q
M
P
G
S
S
F
A
P
S
S
T
I
Site 55
S248
P
G
S
S
F
A
P
S
S
T
I
Y
A
N
N
Site 56
S249
G
S
S
F
A
P
S
S
T
I
Y
A
N
N
S
Site 57
T250
S
S
F
A
P
S
S
T
I
Y
A
N
N
S
V
Site 58
Y252
F
A
P
S
S
T
I
Y
A
N
N
S
V
S
N
Site 59
S256
S
T
I
Y
A
N
N
S
V
S
N
S
T
N
F
Site 60
S258
I
Y
A
N
N
S
V
S
N
S
T
N
F
S
G
Site 61
S260
A
N
N
S
V
S
N
S
T
N
F
S
G
S
Q
Site 62
S264
V
S
N
S
T
N
F
S
G
S
Q
Q
D
Y
P
Site 63
S266
N
S
T
N
F
S
G
S
Q
Q
D
Y
P
S
Y
Site 64
Y270
F
S
G
S
Q
Q
D
Y
P
S
Y
T
A
F
G
Site 65
S272
G
S
Q
Q
D
Y
P
S
Y
T
A
F
G
Q
N
Site 66
Y273
S
Q
Q
D
Y
P
S
Y
T
A
F
G
Q
N
Q
Site 67
Y284
G
Q
N
Q
Y
A
Q
Y
Y
S
A
S
T
Y
G
Site 68
Y290
Q
Y
Y
S
A
S
T
Y
G
A
Y
M
T
S
N
Site 69
T303
S
N
N
T
A
D
G
T
P
S
S
T
S
T
Y
Site 70
S305
N
T
A
D
G
T
P
S
S
T
S
T
Y
Q
L
Site 71
S306
T
A
D
G
T
P
S
S
T
S
T
Y
Q
L
Q
Site 72
T309
G
T
P
S
S
T
S
T
Y
Q
L
Q
E
S
L
Site 73
Y310
T
P
S
S
T
S
T
Y
Q
L
Q
E
S
L
P
Site 74
S315
S
T
Y
Q
L
Q
E
S
L
P
G
L
T
N
Q
Site 75
T320
Q
E
S
L
P
G
L
T
N
Q
P
G
E
F
D
Site 76
T328
N
Q
P
G
E
F
D
T
M
Q
S
P
S
T
P
Site 77
S331
G
E
F
D
T
M
Q
S
P
S
T
P
I
K
D
Site 78
S333
F
D
T
M
Q
S
P
S
T
P
I
K
D
L
D
Site 79
T334
D
T
M
Q
S
P
S
T
P
I
K
D
L
D
E
Site 80
T343
I
K
D
L
D
E
R
T
C
R
S
S
G
S
K
Site 81
S346
L
D
E
R
T
C
R
S
S
G
S
K
S
R
G
Site 82
S347
D
E
R
T
C
R
S
S
G
S
K
S
R
G
R
Site 83
S349
R
T
C
R
S
S
G
S
K
S
R
G
R
G
R
Site 84
S351
C
R
S
S
G
S
K
S
R
G
R
G
R
K
N
Site 85
S361
R
G
R
K
N
N
P
S
P
P
P
D
S
D
L
Site 86
S366
N
P
S
P
P
P
D
S
D
L
E
R
V
F
V
Site 87
Y395
T
G
S
Y
A
Q
K
Y
G
K
D
P
P
M
A
Site 88
S438
Q
V
H
I
D
D
V
S
S
D
D
N
G
Q
D
Site 89
S439
V
H
I
D
D
V
S
S
D
D
N
G
Q
D
L
Site 90
S447
D
D
N
G
Q
D
L
S
T
Y
S
F
A
T
D
Site 91
T448
D
N
G
Q
D
L
S
T
Y
S
F
A
T
D
G
Site 92
Y449
N
G
Q
D
L
S
T
Y
S
F
A
T
D
G
F
Site 93
S450
G
Q
D
L
S
T
Y
S
F
A
T
D
G
F
H
Site 94
Y485
M
R
K
L
A
F
R
Y
R
R
V
K
E
L
Y
Site 95
Y492
Y
R
R
V
K
E
L
Y
N
T
Y
K
N
N
V
Site 96
T494
R
V
K
E
L
Y
N
T
Y
K
N
N
V
G
G
Site 97
Y495
V
K
E
L
Y
N
T
Y
K
N
N
V
G
G
L
Site 98
T522
R
A
E
I
E
G
L
T
D
S
W
L
T
N
A
Site 99
S524
E
I
E
G
L
T
D
S
W
L
T
N
A
L
K
Site 100
S534
T
N
A
L
K
S
L
S
I
I
S
T
R
S
N
Site 101
S540
L
S
I
I
S
T
R
S
N
C
I
N
V
L
V
Site 102
Y574
A
F
P
I
E
N
I
Y
S
A
T
K
I
G
K
Site 103
S575
F
P
I
E
N
I
Y
S
A
T
K
I
G
K
E
Site 104
S622
N
M
P
F
W
R
I
S
S
H
S
D
L
L
A
Site 105
S625
F
W
R
I
S
S
H
S
D
L
L
A
L
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation