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Updated November 2019
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Protein Info
Short Name:
SEC24A
Full Name:
Protein transport protein Sec24A
Alias:
SC24A; SEC24 family, member A; SEC24-related protein A
Type:
Mass (Da):
119750
Number AA:
UniProt ID:
O95486
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030127
GO:0005789
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006888
GO:0006886
GO:0016044
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
Q
P
G
I
P
A
S
G
G
A
P
A
S
L
Site 2
S15
A
S
G
G
A
P
A
S
L
Q
A
Q
N
G
A
Site 3
S26
Q
N
G
A
A
L
A
S
G
S
P
Y
T
N
G
Site 4
S28
G
A
A
L
A
S
G
S
P
Y
T
N
G
P
V
Site 5
Y30
A
L
A
S
G
S
P
Y
T
N
G
P
V
Q
N
Site 6
T31
L
A
S
G
S
P
Y
T
N
G
P
V
Q
N
A
Site 7
S41
P
V
Q
N
A
L
L
S
S
Q
E
S
V
S
Q
Site 8
S42
V
Q
N
A
L
L
S
S
Q
E
S
V
S
Q
G
Site 9
S45
A
L
L
S
S
Q
E
S
V
S
Q
G
Y
N
F
Site 10
S47
L
S
S
Q
E
S
V
S
Q
G
Y
N
F
Q
L
Site 11
S57
Y
N
F
Q
L
P
G
S
Y
P
H
P
I
P
A
Site 12
Y58
N
F
Q
L
P
G
S
Y
P
H
P
I
P
A
K
Site 13
T66
P
H
P
I
P
A
K
T
L
N
P
V
S
G
Q
Site 14
S71
A
K
T
L
N
P
V
S
G
Q
S
N
Y
G
G
Site 15
S74
L
N
P
V
S
G
Q
S
N
Y
G
G
S
Q
G
Site 16
Y76
P
V
S
G
Q
S
N
Y
G
G
S
Q
G
S
G
Site 17
S79
G
Q
S
N
Y
G
G
S
Q
G
S
G
Q
T
L
Site 18
S93
L
N
R
P
P
V
A
S
N
P
V
T
P
S
L
Site 19
T97
P
V
A
S
N
P
V
T
P
S
L
H
S
G
P
Site 20
S99
A
S
N
P
V
T
P
S
L
H
S
G
P
A
P
Site 21
S113
P
R
M
P
L
P
A
S
Q
N
P
A
T
T
P
Site 22
T118
P
A
S
Q
N
P
A
T
T
P
M
P
S
S
S
Site 23
T119
A
S
Q
N
P
A
T
T
P
M
P
S
S
S
F
Site 24
S123
P
A
T
T
P
M
P
S
S
S
F
L
P
E
A
Site 25
S124
A
T
T
P
M
P
S
S
S
F
L
P
E
A
N
Site 26
S125
T
T
P
M
P
S
S
S
F
L
P
E
A
N
L
Site 27
Y140
P
P
P
L
N
W
Q
Y
N
Y
P
S
T
A
S
Site 28
Y142
P
L
N
W
Q
Y
N
Y
P
S
T
A
S
Q
T
Site 29
S156
T
N
H
C
P
R
A
S
S
Q
P
T
V
S
G
Site 30
S157
N
H
C
P
R
A
S
S
Q
P
T
V
S
G
N
Site 31
T160
P
R
A
S
S
Q
P
T
V
S
G
N
T
S
L
Site 32
S162
A
S
S
Q
P
T
V
S
G
N
T
S
L
T
T
Site 33
S166
P
T
V
S
G
N
T
S
L
T
T
N
H
Q
Y
Site 34
Y173
S
L
T
T
N
H
Q
Y
V
S
S
G
Y
P
S
Site 35
S176
T
N
H
Q
Y
V
S
S
G
Y
P
S
L
Q
N
Site 36
Y178
H
Q
Y
V
S
S
G
Y
P
S
L
Q
N
S
F
Site 37
S180
Y
V
S
S
G
Y
P
S
L
Q
N
S
F
I
K
Site 38
S184
G
Y
P
S
L
Q
N
S
F
I
K
S
G
P
S
Site 39
S188
L
Q
N
S
F
I
K
S
G
P
S
V
P
P
L
Site 40
S191
S
F
I
K
S
G
P
S
V
P
P
L
V
N
P
Site 41
T203
V
N
P
P
L
P
T
T
F
Q
P
G
A
P
H
Site 42
T225
P
P
P
V
R
A
L
T
P
L
T
S
S
Y
R
Site 43
S229
R
A
L
T
P
L
T
S
S
Y
R
D
V
P
Q
Site 44
S230
A
L
T
P
L
T
S
S
Y
R
D
V
P
Q
P
Site 45
S250
V
N
Q
E
G
I
T
S
N
T
N
N
G
S
M
Site 46
T252
Q
E
G
I
T
S
N
T
N
N
G
S
M
V
V
Site 47
S256
T
S
N
T
N
N
G
S
M
V
V
H
S
S
Y
Site 48
S261
N
G
S
M
V
V
H
S
S
Y
D
E
I
E
G
Site 49
S262
G
S
M
V
V
H
S
S
Y
D
E
I
E
G
G
Site 50
Y263
S
M
V
V
H
S
S
Y
D
E
I
E
G
G
G
Site 51
T274
E
G
G
G
L
L
A
T
P
Q
L
T
N
K
N
Site 52
S285
T
N
K
N
P
K
M
S
R
S
V
G
Y
S
Y
Site 53
S287
K
N
P
K
M
S
R
S
V
G
Y
S
Y
P
S
Site 54
Y290
K
M
S
R
S
V
G
Y
S
Y
P
S
L
P
P
Site 55
S291
M
S
R
S
V
G
Y
S
Y
P
S
L
P
P
G
Site 56
Y292
S
R
S
V
G
Y
S
Y
P
S
L
P
P
G
Y
Site 57
S294
S
V
G
Y
S
Y
P
S
L
P
P
G
Y
Q
N
Site 58
Y299
Y
P
S
L
P
P
G
Y
Q
N
T
T
P
P
G
Site 59
T302
L
P
P
G
Y
Q
N
T
T
P
P
G
A
T
G
Site 60
T303
P
P
G
Y
Q
N
T
T
P
P
G
A
T
G
V
Site 61
S313
G
A
T
G
V
P
P
S
S
L
N
Y
P
S
G
Site 62
S314
A
T
G
V
P
P
S
S
L
N
Y
P
S
G
P
Site 63
Y317
V
P
P
S
S
L
N
Y
P
S
G
P
Q
A
F
Site 64
S319
P
S
S
L
N
Y
P
S
G
P
Q
A
F
T
Q
Site 65
T325
P
S
G
P
Q
A
F
T
Q
T
P
L
G
A
N
Site 66
T327
G
P
Q
A
F
T
Q
T
P
L
G
A
N
H
L
Site 67
T335
P
L
G
A
N
H
L
T
T
S
M
S
G
L
S
Site 68
S337
G
A
N
H
L
T
T
S
M
S
G
L
S
L
Q
Site 69
S339
N
H
L
T
T
S
M
S
G
L
S
L
Q
P
E
Site 70
S342
T
T
S
M
S
G
L
S
L
Q
P
E
G
L
R
Site 71
S362
Q
E
R
N
M
L
P
S
T
P
L
K
P
P
V
Site 72
T363
E
R
N
M
L
P
S
T
P
L
K
P
P
V
P
Site 73
T389
N
P
E
L
F
R
C
T
L
T
S
I
P
Q
T
Site 74
T391
E
L
F
R
C
T
L
T
S
I
P
Q
T
Q
A
Site 75
T396
T
L
T
S
I
P
Q
T
Q
A
L
L
N
K
A
Site 76
S426
Q
L
P
V
V
T
S
S
T
I
V
R
C
R
S
Site 77
Y437
R
C
R
S
C
R
T
Y
I
N
P
F
V
S
F
Site 78
Y467
D
V
P
E
E
F
L
Y
N
P
L
T
R
V
Y
Site 79
T471
E
F
L
Y
N
P
L
T
R
V
Y
G
E
P
H
Site 80
Y474
Y
N
P
L
T
R
V
Y
G
E
P
H
R
R
P
Site 81
Y496
E
F
M
A
P
S
E
Y
M
L
R
P
P
Q
P
Site 82
Y521
H
N
A
V
E
T
G
Y
L
N
S
V
C
Q
S
Site 83
S561
H
F
Y
G
L
Q
E
S
L
S
Q
P
Q
M
L
Site 84
T609
L
P
Q
M
F
T
K
T
L
E
T
Q
S
A
L
Site 85
S628
Q
A
A
F
K
L
M
S
P
T
G
G
R
M
S
Site 86
S635
S
P
T
G
G
R
M
S
V
F
Q
T
Q
L
P
Site 87
S660
E
E
P
N
H
R
S
S
A
K
D
I
H
M
T
Site 88
T667
S
A
K
D
I
H
M
T
P
S
T
D
F
Y
K
Site 89
Y673
M
T
P
S
T
D
F
Y
K
K
L
A
L
D
C
Site 90
S681
K
K
L
A
L
D
C
S
G
Q
Q
V
A
V
D
Site 91
S701
G
Q
Y
S
D
L
A
S
L
G
C
I
S
R
Y
Site 92
Y708
S
L
G
C
I
S
R
Y
S
A
G
S
V
Y
Y
Site 93
S712
I
S
R
Y
S
A
G
S
V
Y
Y
Y
P
S
Y
Site 94
Y714
R
Y
S
A
G
S
V
Y
Y
Y
P
S
Y
H
H
Site 95
Y715
Y
S
A
G
S
V
Y
Y
Y
P
S
Y
H
H
Q
Site 96
Y716
S
A
G
S
V
Y
Y
Y
P
S
Y
H
H
Q
H
Site 97
Y719
S
V
Y
Y
Y
P
S
Y
H
H
Q
H
N
P
V
Site 98
Y738
L
Q
K
E
L
Q
R
Y
L
T
R
K
I
G
F
Site 99
T740
K
E
L
Q
R
Y
L
T
R
K
I
G
F
E
A
Site 100
T771
G
N
F
F
V
R
S
T
D
L
L
S
L
P
N
Site 101
S775
V
R
S
T
D
L
L
S
L
P
N
V
N
P
D
Site 102
Y785
N
V
N
P
D
A
G
Y
A
V
Q
M
S
V
E
Site 103
S790
A
G
Y
A
V
Q
M
S
V
E
E
S
L
T
D
Site 104
S794
V
Q
M
S
V
E
E
S
L
T
D
T
Q
L
V
Site 105
T796
M
S
V
E
E
S
L
T
D
T
Q
L
V
S
F
Site 106
T798
V
E
E
S
L
T
D
T
Q
L
V
S
F
Q
S
Site 107
Y809
S
F
Q
S
A
L
L
Y
T
S
S
K
G
E
R
Site 108
S812
S
A
L
L
Y
T
S
S
K
G
E
R
R
I
R
Site 109
S855
A
N
M
A
V
D
R
S
M
T
A
S
L
S
D
Site 110
T857
M
A
V
D
R
S
M
T
A
S
L
S
D
A
R
Site 111
S859
V
D
R
S
M
T
A
S
L
S
D
A
R
D
A
Site 112
S861
R
S
M
T
A
S
L
S
D
A
R
D
A
L
V
Site 113
S880
D
S
L
S
A
Y
R
S
S
V
L
S
N
Q
Q
Site 114
S881
S
L
S
A
Y
R
S
S
V
L
S
N
Q
Q
P
Site 115
S884
A
Y
R
S
S
V
L
S
N
Q
Q
P
G
L
M
Site 116
S911
L
A
L
L
K
Q
K
S
F
Q
T
G
T
N
A
Site 117
Y947
L
T
T
H
P
S
L
Y
R
V
D
N
L
S
D
Site 118
S953
L
Y
R
V
D
N
L
S
D
E
G
A
L
N
I
Site 119
S961
D
E
G
A
L
N
I
S
D
R
T
I
P
Q
P
Site 120
S974
Q
P
P
I
L
Q
L
S
V
E
K
L
S
R
D
Site 121
Y1014
Q
V
L
G
V
Q
N
Y
A
S
I
P
Q
P
M
Site 122
T1022
A
S
I
P
Q
P
M
T
D
L
P
E
L
D
T
Site 123
T1029
T
D
L
P
E
L
D
T
P
E
S
A
R
I
I
Site 124
S1040
A
R
I
I
A
F
I
S
W
L
R
E
Q
R
P
Site 125
Y1053
R
P
F
F
P
I
L
Y
V
I
R
D
E
S
P
Site 126
S1059
L
Y
V
I
R
D
E
S
P
M
K
A
N
F
L
Site 127
T1074
Q
N
M
I
E
D
R
T
E
S
A
L
S
Y
Y
Site 128
S1076
M
I
E
D
R
T
E
S
A
L
S
Y
Y
E
F
Site 129
S1079
D
R
T
E
S
A
L
S
Y
Y
E
F
L
L
H
Site 130
Y1080
R
T
E
S
A
L
S
Y
Y
E
F
L
L
H
I
Site 131
Y1081
T
E
S
A
L
S
Y
Y
E
F
L
L
H
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation