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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
H6PD
Full Name:
GDH/6PGL endoplasmic bifunctional protein
Alias:
6PGL; 6PGL;G6PE; 6-phosphogluconolactonase; EC 1.1.1.47; EC 3.1.1.31; G6PE; GDH; Glucose 1-dehydrogenase; Hexose-6-phosphate dehydrogenase
Type:
Oxidoreductase; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.1.31; Hydrolase; EC 1.1.1.47
Mass (Da):
88893
Number AA:
791
UniProt ID:
O95479
International Prot ID:
IPI00607861
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0017057
GO:0005488
GO:0047936
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y41
T
G
D
L
A
K
K
Y
L
W
Q
G
L
F
Q
Site 2
Y50
W
Q
G
L
F
Q
L
Y
L
D
E
A
G
R
G
Site 3
S59
D
E
A
G
R
G
H
S
F
S
F
H
G
A
A
Site 4
S61
A
G
R
G
H
S
F
S
F
H
G
A
A
L
T
Site 5
T68
S
F
H
G
A
A
L
T
A
P
K
Q
G
Q
E
Site 6
S85
A
K
A
L
E
S
L
S
C
P
K
D
M
A
P
Site 7
S106
K
D
Q
F
L
Q
L
S
Q
Y
R
Q
L
K
T
Site 8
T113
S
Q
Y
R
Q
L
K
T
A
E
D
Y
Q
A
L
Site 9
Y117
Q
L
K
T
A
E
D
Y
Q
A
L
N
K
D
I
Site 10
S158
D
I
A
R
N
I
N
S
S
C
R
P
G
P
G
Site 11
S159
I
A
R
N
I
N
S
S
C
R
P
G
P
G
A
Site 12
S182
P
F
G
H
D
H
F
S
A
Q
Q
L
A
T
E
Site 13
Y200
F
F
Q
E
E
E
M
Y
R
V
D
H
Y
L
G
Site 14
Y205
E
M
Y
R
V
D
H
Y
L
G
K
Q
A
V
A
Site 15
S252
V
D
A
E
G
R
T
S
F
Y
E
E
Y
G
V
Site 16
Y254
A
E
G
R
T
S
F
Y
E
E
Y
G
V
I
R
Site 17
Y257
R
T
S
F
Y
E
E
Y
G
V
I
R
D
V
L
Site 18
S307
L
R
G
L
Q
R
G
S
A
V
V
G
Q
Y
Q
Site 19
Y313
G
S
A
V
V
G
Q
Y
Q
S
Y
S
E
Q
V
Site 20
S315
A
V
V
G
Q
Y
Q
S
Y
S
E
Q
V
R
R
Site 21
Y316
V
V
G
Q
Y
Q
S
Y
S
E
Q
V
R
R
E
Site 22
S317
V
G
Q
Y
Q
S
Y
S
E
Q
V
R
R
E
L
Site 23
S329
R
E
L
Q
K
P
D
S
F
H
S
L
T
P
T
Site 24
S332
Q
K
P
D
S
F
H
S
L
T
P
T
F
A
A
Site 25
Y368
A
L
D
E
R
V
G
Y
A
R
I
L
F
K
N
Site 26
S415
G
S
P
A
V
L
V
S
R
N
L
F
R
P
S
Site 27
S422
S
R
N
L
F
R
P
S
L
P
S
S
W
K
E
Site 28
S425
L
F
R
P
S
L
P
S
S
W
K
E
M
E
G
Site 29
S426
F
R
P
S
L
P
S
S
W
K
E
M
E
G
P
Site 30
S441
P
G
L
R
L
F
G
S
P
L
S
D
Y
Y
A
Site 31
S444
R
L
F
G
S
P
L
S
D
Y
Y
A
Y
S
P
Site 32
Y446
F
G
S
P
L
S
D
Y
Y
A
Y
S
P
V
R
Site 33
Y447
G
S
P
L
S
D
Y
Y
A
Y
S
P
V
R
E
Site 34
Y449
P
L
S
D
Y
Y
A
Y
S
P
V
R
E
R
D
Site 35
S450
L
S
D
Y
Y
A
Y
S
P
V
R
E
R
D
A
Site 36
S459
V
R
E
R
D
A
H
S
V
L
L
S
H
I
F
Site 37
S463
D
A
H
S
V
L
L
S
H
I
F
H
G
R
K
Site 38
S492
F
W
T
P
L
L
E
S
L
A
H
K
A
P
R
Site 39
Y501
A
H
K
A
P
R
L
Y
P
G
G
A
E
N
G
Site 40
S523
S
S
G
R
L
F
F
S
Q
Q
Q
P
E
Q
L
Site 41
S541
P
G
P
A
P
M
P
S
D
F
Q
V
L
R
A
Site 42
Y550
F
Q
V
L
R
A
K
Y
R
E
S
P
L
V
S
Site 43
S553
L
R
A
K
Y
R
E
S
P
L
V
S
A
W
S
Site 44
S557
Y
R
E
S
P
L
V
S
A
W
S
E
E
L
I
Site 45
Y607
Q
Q
L
A
T
A
H
Y
G
F
P
W
A
H
T
Site 46
S627
D
E
R
C
V
P
L
S
D
P
E
S
N
F
Q
Site 47
S631
V
P
L
S
D
P
E
S
N
F
Q
G
L
Q
A
Site 48
Y648
L
Q
H
V
R
I
P
Y
Y
N
I
H
P
M
P
Site 49
Y649
Q
H
V
R
I
P
Y
Y
N
I
H
P
M
P
V
Site 50
Y673
E
D
Q
G
A
Q
I
Y
A
R
E
I
S
A
L
Site 51
T699
G
M
G
A
D
G
H
T
A
S
L
F
P
Q
S
Site 52
S701
G
A
D
G
H
T
A
S
L
F
P
Q
S
P
T
Site 53
S706
T
A
S
L
F
P
Q
S
P
T
G
L
D
G
E
Site 54
T719
G
E
Q
L
V
V
L
T
T
S
P
S
Q
P
H
Site 55
T720
E
Q
L
V
V
L
T
T
S
P
S
Q
P
H
R
Site 56
S721
Q
L
V
V
L
T
T
S
P
S
Q
P
H
R
R
Site 57
S723
V
V
L
T
T
S
P
S
Q
P
H
R
R
M
S
Site 58
S730
S
Q
P
H
R
R
M
S
L
S
L
P
L
I
N
Site 59
S732
P
H
R
R
M
S
L
S
L
P
L
I
N
R
A
Site 60
T755
G
R
M
K
R
E
I
T
T
L
V
S
R
V
G
Site 61
S771
E
P
K
K
W
P
I
S
G
V
L
P
H
S
G
Site 62
Y783
H
S
G
Q
L
V
W
Y
M
D
Y
D
A
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation