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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS2
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 2
Alias:
Procollagen I N-proteinase;Procollagen I/II amino propeptide-processing enzyme;Procollagen N-endopeptidase
Type:
Mass (Da):
134755
Number AA:
1211
UniProt ID:
O95450
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S80
H
V
V
S
A
A
T
S
R
A
G
V
R
A
R
Site 2
T94
R
R
A
A
P
V
R
T
P
S
F
P
G
G
N
Site 3
S96
A
A
P
V
R
T
P
S
F
P
G
G
N
E
E
Site 4
S107
G
N
E
E
E
P
G
S
H
L
F
Y
N
V
T
Site 5
Y111
E
P
G
S
H
L
F
Y
N
V
T
V
F
G
R
Site 6
T145
E
W
Q
G
E
K
G
T
T
R
V
E
P
L
L
Site 7
Y212
Q
G
R
V
H
V
V
Y
R
R
P
P
T
S
P
Site 8
T217
V
V
Y
R
R
P
P
T
S
P
P
L
G
G
P
Site 9
S218
V
Y
R
R
P
P
T
S
P
P
L
G
G
P
Q
Site 10
T229
G
G
P
Q
A
L
D
T
G
A
S
L
D
S
L
Site 11
S232
Q
A
L
D
T
G
A
S
L
D
S
L
D
S
L
Site 12
S235
D
T
G
A
S
L
D
S
L
D
S
L
S
R
A
Site 13
S252
V
L
E
E
H
A
N
S
S
R
R
R
A
R
R
Site 14
S253
L
E
E
H
A
N
S
S
R
R
R
A
R
R
H
Site 15
Y266
R
H
A
A
D
D
D
Y
N
I
E
V
L
L
G
Site 16
Y290
G
K
E
H
V
Q
K
Y
L
L
T
L
M
N
I
Site 17
Y302
M
N
I
V
N
E
I
Y
H
D
E
S
L
G
A
Site 18
S328
L
S
Y
G
K
S
M
S
L
I
E
I
G
N
P
Site 19
S338
E
I
G
N
P
S
Q
S
L
E
N
V
C
R
W
Site 20
Y347
E
N
V
C
R
W
A
Y
L
Q
Q
K
P
D
T
Site 21
T354
Y
L
Q
Q
K
P
D
T
G
H
D
E
Y
H
D
Site 22
Y359
P
D
T
G
H
D
E
Y
H
D
H
A
I
F
L
Site 23
T367
H
D
H
A
I
F
L
T
R
Q
D
F
G
P
S
Site 24
Y379
G
P
S
G
M
Q
G
Y
A
P
V
T
G
M
C
Site 25
S452
R
F
H
W
S
R
C
S
Q
Q
E
L
S
R
Y
Site 26
S457
R
C
S
Q
Q
E
L
S
R
Y
L
H
S
Y
D
Site 27
Y459
S
Q
Q
E
L
S
R
Y
L
H
S
Y
D
C
L
Site 28
S462
E
L
S
R
Y
L
H
S
Y
D
C
L
L
D
D
Site 29
Y463
L
S
R
Y
L
H
S
Y
D
C
L
L
D
D
P
Site 30
Y486
P
Q
L
P
G
L
H
Y
S
M
N
E
Q
C
R
Site 31
Y524
C
S
H
P
D
N
P
Y
F
C
K
T
K
K
G
Site 32
T528
D
N
P
Y
F
C
K
T
K
K
G
P
P
L
D
Site 33
T537
K
G
P
P
L
D
G
T
M
C
A
P
G
K
H
Site 34
T554
K
G
H
C
I
W
L
T
P
D
I
L
K
R
D
Site 35
S563
D
I
L
K
R
D
G
S
W
G
A
W
S
P
F
Site 36
S568
D
G
S
W
G
A
W
S
P
F
G
S
C
S
R
Site 37
S572
G
A
W
S
P
F
G
S
C
S
R
T
C
G
T
Site 38
S574
W
S
P
F
G
S
C
S
R
T
C
G
T
G
V
Site 39
T576
P
F
G
S
C
S
R
T
C
G
T
G
V
K
F
Site 40
S601
A
N
G
G
R
T
C
S
G
L
A
Y
D
F
Q
Site 41
Y605
R
T
C
S
G
L
A
Y
D
F
Q
L
C
S
R
Site 42
S618
S
R
Q
D
C
P
D
S
L
A
D
F
R
E
E
Site 43
Y633
Q
C
R
Q
W
D
L
Y
F
E
H
G
D
A
Q
Site 44
Y658
A
K
E
R
C
H
L
Y
C
E
S
R
E
T
G
Site 45
T664
L
Y
C
E
S
R
E
T
G
E
V
V
S
M
K
Site 46
S669
R
E
T
G
E
V
V
S
M
K
R
M
V
H
D
Site 47
T678
K
R
M
V
H
D
G
T
R
C
S
Y
K
D
A
Site 48
S681
V
H
D
G
T
R
C
S
Y
K
D
A
F
S
L
Site 49
Y682
H
D
G
T
R
C
S
Y
K
D
A
F
S
L
C
Site 50
T728
H
C
K
V
V
K
G
T
F
T
R
S
P
K
K
Site 51
T730
K
V
V
K
G
T
F
T
R
S
P
K
K
H
G
Site 52
S732
V
K
G
T
F
T
R
S
P
K
K
H
G
Y
I
Site 53
Y738
R
S
P
K
K
H
G
Y
I
K
M
F
E
I
P
Site 54
S785
E
N
D
V
D
A
S
S
K
T
F
I
A
M
G
Site 55
T805
R
D
E
D
G
R
E
T
L
Q
T
M
G
P
L
Site 56
T808
D
G
R
E
T
L
Q
T
M
G
P
L
H
G
T
Site 57
S829
P
V
G
D
T
R
V
S
L
T
Y
K
Y
M
I
Site 58
T831
G
D
T
R
V
S
L
T
Y
K
Y
M
I
H
E
Site 59
Y832
D
T
R
V
S
L
T
Y
K
Y
M
I
H
E
D
Site 60
Y834
R
V
S
L
T
Y
K
Y
M
I
H
E
D
S
L
Site 61
S853
N
N
V
L
E
E
D
S
V
V
Y
E
W
A
L
Site 62
S867
L
K
K
W
S
P
C
S
K
P
C
G
G
G
S
Site 63
S874
S
K
P
C
G
G
G
S
Q
F
T
K
Y
G
C
Site 64
Y879
G
G
S
Q
F
T
K
Y
G
C
R
R
R
L
D
Site 65
S899
R
G
F
C
A
A
L
S
K
P
K
A
I
R
R
Site 66
S939
R
T
G
M
Q
V
R
S
V
R
C
I
Q
P
L
Site 67
T950
I
Q
P
L
H
D
N
T
T
R
S
V
H
A
K
Site 68
T951
Q
P
L
H
D
N
T
T
R
S
V
H
A
K
H
Site 69
S966
C
N
D
A
R
P
E
S
R
R
A
C
S
R
E
Site 70
S971
P
E
S
R
R
A
C
S
R
E
L
C
P
G
R
Site 71
T1004
E
R
P
V
L
C
R
T
A
D
D
S
F
G
I
Site 72
S1008
L
C
R
T
A
D
D
S
F
G
I
C
Q
E
E
Site 73
T1019
C
Q
E
E
R
P
E
T
A
R
T
C
R
L
G
Site 74
T1022
E
R
P
E
T
A
R
T
C
R
L
G
P
C
P
Site 75
S1033
G
P
C
P
R
N
I
S
D
P
S
K
K
S
Y
Site 76
S1036
P
R
N
I
S
D
P
S
K
K
S
Y
V
V
Q
Site 77
S1039
I
S
D
P
S
K
K
S
Y
V
V
Q
W
L
S
Site 78
Y1040
S
D
P
S
K
K
S
Y
V
V
Q
W
L
S
R
Site 79
S1046
S
Y
V
V
Q
W
L
S
R
P
D
P
D
S
P
Site 80
S1052
L
S
R
P
D
P
D
S
P
I
R
K
I
S
S
Site 81
S1058
D
S
P
I
R
K
I
S
S
K
G
H
C
Q
G
Site 82
Y1079
R
M
E
V
L
S
R
Y
C
S
I
P
G
Y
N
Site 83
S1081
E
V
L
S
R
Y
C
S
I
P
G
Y
N
K
L
Site 84
Y1085
R
Y
C
S
I
P
G
Y
N
K
L
C
C
K
S
Site 85
Y1096
C
C
K
S
C
N
L
Y
N
N
L
T
N
V
E
Site 86
S1135
V
A
M
E
V
R
P
S
P
S
T
P
L
E
V
Site 87
T1138
E
V
R
P
S
P
S
T
P
L
E
V
P
L
N
Site 88
Y1165
T
N
A
V
D
E
P
Y
K
I
H
G
L
E
D
Site 89
S1185
N
L
I
P
R
R
P
S
P
Y
E
K
T
R
N
Site 90
Y1187
I
P
R
R
P
S
P
Y
E
K
T
R
N
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation