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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARIH2
Full Name:
E3 ubiquitin-protein ligase ARIH2
Alias:
ARI2; ARI-2; Ariadne 2; Ariadne-2; Protein ariadne-2 homolog; TRIAD1
Type:
Ubiquitin conjugating system
Mass (Da):
57819
Number AA:
493
UniProt ID:
O95376
International Prot ID:
IPI00007304
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
V
D
M
N
S
Q
G
S
D
S
N
E
Site 2
S10
V
D
M
N
S
Q
G
S
D
S
N
E
E
D
Y
Site 3
S12
M
N
S
Q
G
S
D
S
N
E
E
D
Y
D
P
Site 4
Y17
S
D
S
N
E
E
D
Y
D
P
N
C
E
E
E
Site 5
Y38
D
P
G
D
I
E
D
Y
Y
V
G
V
A
S
D
Site 6
Y39
P
G
D
I
E
D
Y
Y
V
G
V
A
S
D
V
Site 7
S44
D
Y
Y
V
G
V
A
S
D
V
E
Q
Q
G
A
Site 8
T62
D
P
E
E
Y
Q
F
T
C
L
T
Y
K
E
S
Site 9
T65
E
Y
Q
F
T
C
L
T
Y
K
E
S
E
G
A
Site 10
S69
T
C
L
T
Y
K
E
S
E
G
A
L
N
E
H
Site 11
S82
E
H
M
T
S
L
A
S
V
L
K
V
S
H
S
Site 12
Y109
V
S
E
I
L
D
R
Y
K
S
N
S
A
Q
L
Site 13
S111
E
I
L
D
R
Y
K
S
N
S
A
Q
L
L
V
Site 14
S113
L
D
R
Y
K
S
N
S
A
Q
L
L
V
E
A
Site 15
S127
A
R
V
Q
P
N
P
S
K
H
V
P
T
S
H
Site 16
T132
N
P
S
K
H
V
P
T
S
H
P
P
H
H
C
Site 17
S133
P
S
K
H
V
P
T
S
H
P
P
H
H
C
A
Site 18
S153
V
R
K
E
N
L
L
S
L
A
C
Q
H
Q
F
Site 19
T192
A
Q
D
C
P
L
R
T
P
E
D
F
V
F
P
Site 20
Y210
N
E
E
L
R
E
K
Y
R
R
Y
L
F
R
D
Site 21
Y213
L
R
E
K
Y
R
R
Y
L
F
R
D
Y
V
E
Site 22
Y218
R
R
Y
L
F
R
D
Y
V
E
S
H
Y
Q
L
Site 23
Y223
R
D
Y
V
E
S
H
Y
Q
L
Q
L
C
P
G
Site 24
T272
H
A
P
T
D
C
A
T
I
R
K
W
L
T
K
Site 25
S284
L
T
K
C
A
D
D
S
E
T
A
N
Y
I
S
Site 26
T286
K
C
A
D
D
S
E
T
A
N
Y
I
S
A
H
Site 27
Y289
D
D
S
E
T
A
N
Y
I
S
A
H
T
K
D
Site 28
Y337
W
K
T
H
G
S
E
Y
Y
E
C
S
R
Y
K
Site 29
Y338
K
T
H
G
S
E
Y
Y
E
C
S
R
Y
K
E
Site 30
Y343
E
Y
Y
E
C
S
R
Y
K
E
N
P
D
I
V
Site 31
S353
N
P
D
I
V
N
Q
S
Q
Q
A
Q
A
R
E
Site 32
Y365
A
R
E
A
L
K
K
Y
L
F
Y
F
E
R
W
Site 33
Y368
A
L
K
K
Y
L
F
Y
F
E
R
W
E
N
H
Site 34
S378
R
W
E
N
H
N
K
S
L
Q
L
E
A
Q
T
Site 35
Y386
L
Q
L
E
A
Q
T
Y
Q
R
I
H
E
K
I
Site 36
Y409
G
T
W
I
D
W
Q
Y
L
Q
N
A
A
K
L
Site 37
Y422
K
L
L
A
K
C
R
Y
T
L
Q
Y
T
Y
P
Site 38
T423
L
L
A
K
C
R
Y
T
L
Q
Y
T
Y
P
Y
Site 39
Y426
K
C
R
Y
T
L
Q
Y
T
Y
P
Y
A
Y
Y
Site 40
Y428
R
Y
T
L
Q
Y
T
Y
P
Y
A
Y
Y
M
E
Site 41
Y430
T
L
Q
Y
T
Y
P
Y
A
Y
Y
M
E
S
G
Site 42
Y432
Q
Y
T
Y
P
Y
A
Y
Y
M
E
S
G
P
R
Site 43
Y433
Y
T
Y
P
Y
A
Y
Y
M
E
S
G
P
R
K
Site 44
S436
P
Y
A
Y
Y
M
E
S
G
P
R
K
K
L
F
Site 45
Y445
P
R
K
K
L
F
E
Y
Q
Q
A
Q
L
E
A
Site 46
S458
E
A
E
I
E
N
L
S
W
K
V
E
R
A
D
Site 47
S466
W
K
V
E
R
A
D
S
Y
D
R
G
D
L
E
Site 48
Y467
K
V
E
R
A
D
S
Y
D
R
G
D
L
E
N
Site 49
T485
I
A
E
Q
R
R
R
T
L
L
K
D
F
H
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation