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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMC2L1
Full Name:
Structural maintenance of chromosomes protein 2
Alias:
CAPE; CAP-E; Chromosome-associated protein E; HCAP-E; SMC2; Structural maintenance of chromosomes 2; XCAP-E
Type:
Cell cycle regulation, condesin complex protein
Mass (Da):
135781
Number AA:
1197
UniProt ID:
O95347
International Prot ID:
IPI00007927
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000796
GO:0005737
GO:0000228
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007076
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
I
I
L
E
G
F
K
S
Y
A
Q
R
T
E
V
Site 2
T31
D
P
L
F
N
A
I
T
G
L
N
G
S
G
K
Site 3
S36
A
I
T
G
L
N
G
S
G
K
S
N
I
L
D
Site 4
S39
G
L
N
G
S
G
K
S
N
I
L
D
S
I
C
Site 5
S60
N
L
S
Q
V
R
A
S
N
L
Q
D
L
V
Y
Site 6
Y67
S
N
L
Q
D
L
V
Y
K
N
G
Q
A
G
I
Site 7
S78
Q
A
G
I
T
K
A
S
V
S
I
T
F
D
N
Site 8
S80
G
I
T
K
A
S
V
S
I
T
F
D
N
S
D
Site 9
T82
T
K
A
S
V
S
I
T
F
D
N
S
D
K
K
Site 10
S86
V
S
I
T
F
D
N
S
D
K
K
Q
S
P
L
Site 11
S91
D
N
S
D
K
K
Q
S
P
L
G
F
E
V
H
Site 12
T171
M
I
E
E
A
A
G
T
R
M
Y
E
Y
K
K
Site 13
Y174
E
A
A
G
T
R
M
Y
E
Y
K
K
I
A
A
Site 14
Y176
A
G
T
R
M
Y
E
Y
K
K
I
A
A
Q
K
Site 15
T184
K
K
I
A
A
Q
K
T
I
E
K
K
E
A
K
Site 16
T197
A
K
L
K
E
I
K
T
I
L
E
E
E
I
T
Site 17
T204
T
I
L
E
E
E
I
T
P
T
I
Q
K
L
K
Site 18
T206
L
E
E
E
I
T
P
T
I
Q
K
L
K
E
E
Site 19
S215
Q
K
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
Site 20
S216
K
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
Site 21
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
M
Site 22
Y220
E
R
S
S
Y
L
E
Y
Q
K
V
M
R
E
I
Site 23
Y237
L
S
R
L
Y
I
A
Y
Q
F
L
L
A
E
D
Site 24
T245
Q
F
L
L
A
E
D
T
K
V
R
S
A
E
E
Site 25
S249
A
E
D
T
K
V
R
S
A
E
E
L
K
E
M
Site 26
S268
I
K
L
Q
E
E
L
S
E
N
D
K
K
I
K
Site 27
T292
E
K
R
K
D
K
E
T
G
G
I
L
R
S
L
Site 28
S298
E
T
G
G
I
L
R
S
L
E
D
A
L
A
E
Site 29
T311
A
E
A
Q
R
V
N
T
K
S
Q
S
A
F
D
Site 30
S313
A
Q
R
V
N
T
K
S
Q
S
A
F
D
L
K
Site 31
S315
R
V
N
T
K
S
Q
S
A
F
D
L
K
K
K
Site 32
S329
K
N
L
A
C
E
E
S
K
R
K
E
L
E
K
Site 33
S342
E
K
N
M
V
E
D
S
K
T
L
A
A
K
E
Site 34
T344
N
M
V
E
D
S
K
T
L
A
A
K
E
K
E
Site 35
S384
Q
Q
H
F
N
A
V
S
A
G
L
S
S
N
E
Site 36
S388
N
A
V
S
A
G
L
S
S
N
E
D
G
A
E
Site 37
T414
N
D
I
S
K
A
Q
T
E
A
K
Q
A
Q
M
Site 38
S442
A
E
V
K
K
M
D
S
G
Y
R
K
D
Q
E
Site 39
Y444
V
K
K
M
D
S
G
Y
R
K
D
Q
E
A
L
Site 40
S486
L
E
K
R
R
Q
L
S
R
D
I
G
R
L
K
Site 41
Y496
I
G
R
L
K
E
T
Y
E
A
L
L
A
R
F
Site 42
Y510
F
P
N
L
R
F
A
Y
K
D
P
E
K
N
W
Site 43
Y573
R
G
E
L
K
R
R
Y
T
I
I
P
L
N
K
Site 44
T574
G
E
L
K
R
R
Y
T
I
I
P
L
N
K
I
Site 45
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Site 46
T649
D
K
R
I
M
T
R
T
V
T
L
G
G
D
V
Site 47
S664
F
D
P
H
G
T
L
S
G
G
A
R
S
Q
A
Site 48
S673
G
A
R
S
Q
A
A
S
I
L
T
K
F
Q
E
Site 49
Y738
T
K
L
Q
Q
S
S
Y
H
K
Q
Q
E
E
L
Site 50
T751
E
L
D
A
L
K
K
T
I
E
E
S
E
E
T
Site 51
T758
T
I
E
E
S
E
E
T
L
K
N
T
K
E
I
Site 52
Y773
Q
R
K
A
E
E
K
Y
E
V
L
E
N
K
M
Site 53
T803
K
K
L
D
C
A
K
T
K
A
D
A
S
S
K
Site 54
T834
E
E
L
K
R
E
H
T
S
Y
K
Q
Q
L
E
Site 55
Y836
L
K
R
E
H
T
S
Y
K
Q
Q
L
E
A
V
Site 56
S849
A
V
N
E
A
I
K
S
Y
E
S
Q
I
E
V
Site 57
Y893
D
T
V
I
K
A
K
Y
A
E
V
A
K
H
K
Site 58
S906
H
K
E
Q
N
N
D
S
Q
L
K
I
K
E
L
Site 59
Y938
V
S
K
M
L
K
D
Y
D
W
I
N
A
E
R
Site 60
Y955
F
G
Q
P
N
S
A
Y
D
F
K
T
N
N
P
Site 61
T959
N
S
A
Y
D
F
K
T
N
N
P
K
E
A
G
Site 62
S1013
R
I
V
E
N
D
K
S
K
I
L
T
T
I
E
Site 63
T1017
N
D
K
S
K
I
L
T
T
I
E
D
L
D
Q
Site 64
T1018
D
K
S
K
I
L
T
T
I
E
D
L
D
Q
K
Site 65
T1083
N
T
W
K
E
N
L
T
E
L
S
G
G
Q
R
Site 66
S1086
K
E
N
L
T
E
L
S
G
G
Q
R
S
L
V
Site 67
S1122
V
D
A
A
L
D
L
S
H
T
Q
N
I
G
Q
Site 68
T1159
N
A
N
V
L
F
K
T
K
F
V
D
G
V
S
Site 69
S1166
T
K
F
V
D
G
V
S
T
V
A
R
F
T
Q
Site 70
T1172
V
S
T
V
A
R
F
T
Q
C
Q
N
G
K
I
Site 71
S1185
K
I
S
K
E
A
K
S
K
A
K
P
P
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation