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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIX3
Full Name:
Homeobox protein SIX3
Alias:
Sine oculis homeobox homolog 3
Type:
Mass (Da):
35487
Number AA:
332
UniProt ID:
O95343
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
F
R
S
P
L
D
L
Y
S
S
H
F
L
L
P
Site 2
S11
R
S
P
L
D
L
Y
S
S
H
F
L
L
P
N
Site 3
S26
F
A
D
S
H
H
R
S
I
L
L
A
S
S
G
Site 4
S48
G
G
G
A
G
G
G
S
G
G
G
N
G
A
G
Site 5
S70
G
G
G
G
G
G
G
S
R
A
P
P
E
E
L
Site 6
S78
R
A
P
P
E
E
L
S
M
F
Q
L
P
T
L
Site 7
T84
L
S
M
F
Q
L
P
T
L
N
F
S
P
E
Q
Site 8
S88
Q
L
P
T
L
N
F
S
P
E
Q
V
A
S
V
Site 9
S94
F
S
P
E
Q
V
A
S
V
C
E
T
L
E
E
Site 10
T98
Q
V
A
S
V
C
E
T
L
E
E
T
G
D
I
Site 11
Y149
T
G
N
F
R
D
L
Y
H
I
L
E
N
H
K
Site 12
Y191
P
L
G
P
V
D
K
Y
R
V
R
K
K
F
P
Site 13
T202
K
K
F
P
L
P
R
T
I
W
D
G
E
Q
K
Site 14
S219
C
F
K
E
R
T
R
S
L
L
R
E
W
Y
L
Site 15
Y225
R
S
L
L
R
E
W
Y
L
Q
D
P
Y
P
N
Site 16
Y230
E
W
Y
L
Q
D
P
Y
P
N
P
S
K
K
R
Site 17
S234
Q
D
P
Y
P
N
P
S
K
K
R
E
L
A
Q
Site 18
T246
L
A
Q
A
T
G
L
T
P
T
Q
V
G
N
W
Site 19
S278
Q
H
Q
A
I
G
P
S
G
M
R
S
L
A
E
Site 20
S282
I
G
P
S
G
M
R
S
L
A
E
P
G
C
P
Site 21
S293
P
G
C
P
T
H
G
S
A
E
S
P
S
T
A
Site 22
S296
P
T
H
G
S
A
E
S
P
S
T
A
A
S
P
Site 23
S298
H
G
S
A
E
S
P
S
T
A
A
S
P
T
T
Site 24
T299
G
S
A
E
S
P
S
T
A
A
S
P
T
T
S
Site 25
S302
E
S
P
S
T
A
A
S
P
T
T
S
V
S
S
Site 26
T304
P
S
T
A
A
S
P
T
T
S
V
S
S
L
T
Site 27
T305
S
T
A
A
S
P
T
T
S
V
S
S
L
T
E
Site 28
S306
T
A
A
S
P
T
T
S
V
S
S
L
T
E
R
Site 29
T311
T
T
S
V
S
S
L
T
E
R
A
D
T
G
T
Site 30
T316
S
L
T
E
R
A
D
T
G
T
S
I
L
S
V
Site 31
T318
T
E
R
A
D
T
G
T
S
I
L
S
V
T
S
Site 32
S319
E
R
A
D
T
G
T
S
I
L
S
V
T
S
S
Site 33
S322
D
T
G
T
S
I
L
S
V
T
S
S
D
S
E
Site 34
T324
G
T
S
I
L
S
V
T
S
S
D
S
E
C
D
Site 35
S326
S
I
L
S
V
T
S
S
D
S
E
C
D
V
_
Site 36
S328
L
S
V
T
S
S
D
S
E
C
D
V
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation