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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCB11
Full Name:
Bile salt export pump
Alias:
ABC member 16, MDR/TAP subfamily; ABC16; ABCBB; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP) member 11; BSEP; PFIC2; PFIC-2; PGY4; SPGP
Type:
Mass (Da):
146389
Number AA:
1321
UniProt ID:
O95342
International Prot ID:
IPI00184848
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0015432
GO:0008554
PhosphoSite+
KinaseNET
Biological Process:
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
D
S
V
I
L
R
S
I
K
K
F
G
E
E
Site 2
S22
E
E
N
D
G
F
E
S
D
K
S
Y
N
N
D
Site 3
S25
D
G
F
E
S
D
K
S
Y
N
N
D
K
K
S
Site 4
Y26
G
F
E
S
D
K
S
Y
N
N
D
K
K
S
R
Site 5
S32
S
Y
N
N
D
K
K
S
R
L
Q
D
E
K
K
Site 6
Y178
I
Q
K
M
R
K
F
Y
F
R
R
I
M
R
M
Site 7
S203
G
E
L
N
T
R
F
S
D
D
I
N
K
I
N
Site 8
Y269
S
V
S
K
F
T
D
Y
E
L
K
A
Y
A
K
Site 9
Y304
E
K
R
E
V
E
R
Y
E
K
N
L
V
F
A
Site 10
S392
T
G
R
A
A
A
T
S
I
F
E
T
I
D
R
Site 11
S407
K
P
I
I
D
C
M
S
E
D
G
Y
K
L
D
Site 12
Y411
D
C
M
S
E
D
G
Y
K
L
D
R
I
K
G
Site 13
T426
E
I
E
F
H
N
V
T
F
H
Y
P
S
R
P
Site 14
Y429
F
H
N
V
T
F
H
Y
P
S
R
P
E
V
K
Site 15
S462
G
P
S
G
A
G
K
S
T
A
L
Q
L
I
Q
Site 16
T480
D
P
C
E
G
M
V
T
V
D
G
H
D
I
R
Site 17
Y518
T
I
A
E
N
I
R
Y
G
R
E
D
A
T
M
Site 18
T524
R
Y
G
R
E
D
A
T
M
E
D
I
V
Q
A
Site 19
Y538
A
A
K
E
A
N
A
Y
N
F
I
M
D
L
P
Site 20
T550
D
L
P
Q
Q
F
D
T
L
V
G
E
G
G
G
Site 21
S560
G
E
G
G
G
Q
M
S
G
G
Q
K
Q
R
V
Site 22
S587
L
L
L
D
M
A
T
S
A
L
D
N
E
S
E
Site 23
T609
S
K
I
Q
H
G
H
T
I
I
S
V
A
H
R
Site 24
S612
Q
H
G
H
T
I
I
S
V
A
H
R
L
S
T
Site 25
T639
G
T
A
V
E
R
G
T
H
E
E
L
L
E
R
Site 26
S658
F
T
L
V
T
L
Q
S
Q
G
N
Q
A
L
N
Site 27
T673
E
E
D
I
K
D
A
T
E
D
D
M
L
A
R
Site 28
T681
E
D
D
M
L
A
R
T
F
S
R
G
S
Y
Q
Site 29
S683
D
M
L
A
R
T
F
S
R
G
S
Y
Q
D
S
Site 30
S686
A
R
T
F
S
R
G
S
Y
Q
D
S
L
R
A
Site 31
Y687
R
T
F
S
R
G
S
Y
Q
D
S
L
R
A
S
Site 32
S690
S
R
G
S
Y
Q
D
S
L
R
A
S
I
R
Q
Site 33
S694
Y
Q
D
S
L
R
A
S
I
R
Q
R
S
K
S
Site 34
S699
R
A
S
I
R
Q
R
S
K
S
Q
L
S
Y
L
Site 35
S701
S
I
R
Q
R
S
K
S
Q
L
S
Y
L
V
H
Site 36
S704
Q
R
S
K
S
Q
L
S
Y
L
V
H
E
P
P
Site 37
Y705
R
S
K
S
Q
L
S
Y
L
V
H
E
P
P
L
Site 38
S719
L
A
V
V
D
H
K
S
T
Y
E
E
D
R
K
Site 39
Y721
V
V
D
H
K
S
T
Y
E
E
D
R
K
D
K
Site 40
S748
V
R
R
I
L
K
F
S
A
P
E
W
P
Y
M
Site 41
S784
S
Q
I
L
G
T
F
S
I
P
D
K
E
E
Q
Site 42
S793
P
D
K
E
E
Q
R
S
Q
I
N
G
V
C
L
Site 43
S823
Q
G
Y
A
F
A
K
S
G
E
L
L
T
K
R
Site 44
T828
A
K
S
G
E
L
L
T
K
R
L
R
K
F
G
Site 45
S853
W
F
D
D
L
R
N
S
P
G
A
L
T
T
R
Site 46
T858
R
N
S
P
G
A
L
T
T
R
L
A
T
D
A
Site 47
T863
A
L
T
T
R
L
A
T
D
A
S
Q
V
Q
G
Site 48
S866
T
R
L
A
T
D
A
S
Q
V
Q
G
A
A
G
Site 49
T923
A
T
Q
T
R
M
L
T
G
F
A
S
R
D
K
Site 50
T949
E
A
L
S
N
I
R
T
V
A
G
I
G
K
E
Site 51
T965
R
F
I
E
A
L
E
T
E
L
E
K
P
F
K
Site 52
Y1005
A
S
Y
R
Y
G
G
Y
L
I
S
N
E
G
L
Site 53
S1008
R
Y
G
G
Y
L
I
S
N
E
G
L
H
F
S
Site 54
S1036
T
A
L
G
R
A
F
S
Y
T
P
S
Y
A
K
Site 55
T1038
L
G
R
A
F
S
Y
T
P
S
Y
A
K
A
K
Site 56
S1040
R
A
F
S
Y
T
P
S
Y
A
K
A
K
I
S
Site 57
Y1041
A
F
S
Y
T
P
S
Y
A
K
A
K
I
S
A
Site 58
S1062
L
D
R
Q
P
P
I
S
V
Y
N
T
A
G
E
Site 59
Y1064
R
Q
P
P
I
S
V
Y
N
T
A
G
E
K
W
Site 60
T1066
P
P
I
S
V
Y
N
T
A
G
E
K
W
D
N
Site 61
Y1087
F
V
D
C
K
F
T
Y
P
S
R
P
D
S
Q
Site 62
S1089
D
C
K
F
T
Y
P
S
R
P
D
S
Q
V
L
Site 63
S1093
T
Y
P
S
R
P
D
S
Q
V
L
N
G
L
S
Site 64
S1114
Q
T
L
A
F
V
G
S
S
G
C
G
K
S
T
Site 65
S1120
G
S
S
G
C
G
K
S
T
S
I
Q
L
L
E
Site 66
S1122
S
G
C
G
K
S
T
S
I
Q
L
L
E
R
F
Site 67
Y1130
I
Q
L
L
E
R
F
Y
D
P
D
Q
G
K
V
Site 68
Y1176
S
I
M
D
N
I
K
Y
G
D
N
T
K
E
I
Site 69
T1180
N
I
K
Y
G
D
N
T
K
E
I
P
M
E
R
Site 70
Y1208
V
M
S
L
P
E
K
Y
E
T
N
V
G
S
Q
Site 71
T1210
S
L
P
E
K
Y
E
T
N
V
G
S
Q
G
S
Site 72
S1214
K
Y
E
T
N
V
G
S
Q
G
S
Q
L
S
R
Site 73
S1220
G
S
Q
G
S
Q
L
S
R
G
E
K
Q
R
I
Site 74
T1251
E
A
T
S
A
L
D
T
E
S
E
K
T
V
Q
Site 75
S1253
T
S
A
L
D
T
E
S
E
K
T
V
Q
V
A
Site 76
T1256
L
D
T
E
S
E
K
T
V
Q
V
A
L
D
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation