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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH1
Full Name:
Potassium voltage-gated channel subfamily H member 1
Alias:
Ether-a-go-go potassium channel 1;Voltage-gated potassium channel subunit Kv10.1
Type:
Mass (Da):
111423
Number AA:
989
UniProt ID:
O95259
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
L
E
N
I
V
R
R
S
N
D
T
N
F
V
L
Site 2
T28
I
V
R
R
S
N
D
T
N
F
V
L
G
N
A
Site 3
Y55
G
F
C
K
L
S
G
Y
H
R
A
E
V
M
Q
Site 4
S68
M
Q
K
S
S
T
C
S
F
M
Y
G
E
L
T
Site 5
T75
S
F
M
Y
G
E
L
T
D
K
D
T
I
E
K
Site 6
T79
G
E
L
T
D
K
D
T
I
E
K
V
R
Q
T
Site 7
T86
T
I
E
K
V
R
Q
T
F
E
N
Y
E
M
N
Site 8
Y90
V
R
Q
T
F
E
N
Y
E
M
N
S
F
E
I
Site 9
Y100
N
S
F
E
I
L
M
Y
K
K
N
R
T
P
V
Site 10
T155
W
G
K
F
A
R
L
T
R
A
L
T
S
S
R
Site 11
T159
A
R
L
T
R
A
L
T
S
S
R
G
V
L
Q
Site 12
S160
R
L
T
R
A
L
T
S
S
R
G
V
L
Q
Q
Site 13
S161
L
T
R
A
L
T
S
S
R
G
V
L
Q
Q
L
Site 14
Y198
G
S
D
I
L
P
Q
Y
K
Q
E
A
P
K
T
Site 15
T205
Y
K
Q
E
A
P
K
T
P
P
H
I
I
L
H
Site 16
S282
G
P
A
G
E
V
I
S
D
P
K
L
I
R
M
Site 17
Y306
D
L
L
S
C
L
P
Y
D
V
I
N
A
F
E
Site 18
S319
F
E
N
V
D
E
V
S
A
F
M
G
D
P
G
Site 19
S343
P
P
L
E
G
R
E
S
Q
G
I
S
S
L
F
Site 20
S347
G
R
E
S
Q
G
I
S
S
L
F
S
S
L
K
Site 21
S348
R
E
S
Q
G
I
S
S
L
F
S
S
L
K
V
Site 22
Y371
V
A
R
K
L
D
H
Y
I
E
Y
G
A
A
V
Site 23
Y403
I
W
Y
S
I
G
D
Y
E
I
F
D
E
D
T
Site 24
T410
Y
E
I
F
D
E
D
T
K
T
I
R
N
N
S
Site 25
T412
I
F
D
E
D
T
K
T
I
R
N
N
S
W
L
Site 26
T428
Q
L
A
M
D
I
G
T
P
Y
Q
F
N
G
S
Site 27
Y430
A
M
D
I
G
T
P
Y
Q
F
N
G
S
G
S
Site 28
S435
T
P
Y
Q
F
N
G
S
G
S
G
K
W
E
G
Site 29
S437
Y
Q
F
N
G
S
G
S
G
K
W
E
G
G
P
Site 30
S445
G
K
W
E
G
G
P
S
K
N
S
V
Y
I
S
Site 31
S448
E
G
G
P
S
K
N
S
V
Y
I
S
S
L
Y
Site 32
Y450
G
P
S
K
N
S
V
Y
I
S
S
L
Y
F
T
Site 33
S452
S
K
N
S
V
Y
I
S
S
L
Y
F
T
M
T
Site 34
S453
K
N
S
V
Y
I
S
S
L
Y
F
T
M
T
S
Site 35
S518
R
Y
H
E
M
L
N
S
V
R
D
F
L
K
L
Site 36
Y526
V
R
D
F
L
K
L
Y
Q
V
P
K
G
L
S
Site 37
S533
Y
Q
V
P
K
G
L
S
E
R
V
M
D
Y
I
Site 38
T552
S
M
S
R
G
I
D
T
E
K
V
L
Q
I
C
Site 39
Y609
C
A
P
G
D
L
I
Y
H
A
G
E
S
V
D
Site 40
T653
D
V
F
W
K
E
A
T
L
A
Q
S
C
A
N
Site 41
S688
L
E
F
Y
T
A
F
S
H
S
F
S
R
N
L
Site 42
T698
F
S
R
N
L
I
L
T
Y
N
L
R
K
R
I
Site 43
S711
R
I
V
F
R
K
I
S
D
V
K
R
E
E
E
Site 44
S777
N
V
L
T
E
H
A
S
A
N
H
S
L
V
K
Site 45
S781
E
H
A
S
A
N
H
S
L
V
K
A
S
V
V
Site 46
T796
T
V
R
E
S
P
A
T
P
V
S
F
Q
A
A
Site 47
S799
E
S
P
A
T
P
V
S
F
Q
A
A
S
T
S
Site 48
S806
S
F
Q
A
A
S
T
S
G
V
P
D
H
A
K
Site 49
S819
A
K
L
Q
A
P
G
S
E
C
L
G
P
K
G
Site 50
S836
G
D
C
A
K
R
K
S
W
A
R
F
K
D
A
Site 51
S854
S
E
D
W
N
K
V
S
K
A
E
S
M
E
T
Site 52
S858
N
K
V
S
K
A
E
S
M
E
T
L
P
E
R
Site 53
T861
S
K
A
E
S
M
E
T
L
P
E
R
T
K
A
Site 54
T873
T
K
A
S
G
E
A
T
L
K
K
T
D
S
C
Site 55
T877
G
E
A
T
L
K
K
T
D
S
C
D
S
G
I
Site 56
S879
A
T
L
K
K
T
D
S
C
D
S
G
I
T
K
Site 57
S882
K
K
T
D
S
C
D
S
G
I
T
K
S
D
L
Site 58
S887
C
D
S
G
I
T
K
S
D
L
R
L
D
N
V
Site 59
S899
D
N
V
G
E
A
R
S
P
Q
D
R
S
P
I
Site 60
S904
A
R
S
P
Q
D
R
S
P
I
L
A
E
V
K
Site 61
S913
I
L
A
E
V
K
H
S
F
Y
P
I
P
E
Q
Site 62
Y915
A
E
V
K
H
S
F
Y
P
I
P
E
Q
T
L
Site 63
T925
P
E
Q
T
L
Q
A
T
V
L
E
V
R
H
E
Site 64
S952
T
N
I
E
K
Q
L
S
E
I
L
R
I
L
T
Site 65
T959
S
E
I
L
R
I
L
T
S
R
R
S
S
Q
S
Site 66
S960
E
I
L
R
I
L
T
S
R
R
S
S
Q
S
P
Site 67
S963
R
I
L
T
S
R
R
S
S
Q
S
P
Q
E
L
Site 68
S964
I
L
T
S
R
R
S
S
Q
S
P
Q
E
L
F
Site 69
S966
T
S
R
R
S
S
Q
S
P
Q
E
L
F
E
I
Site 70
S974
P
Q
E
L
F
E
I
S
R
P
Q
S
P
E
S
Site 71
S978
F
E
I
S
R
P
Q
S
P
E
S
E
R
D
I
Site 72
S981
S
R
P
Q
S
P
E
S
E
R
D
I
F
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation