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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SBF1
Full Name:
Myotubularin-related protein 5
Alias:
Myotubularin related 5; Myotubularin-related 5; SET binding factor 1; SET-binding factor 1
Type:
Protein phosphatase, inactive pseudo-phosphatase, regulatory
Mass (Da):
208315
Number AA:
1867
UniProt ID:
O95248
International Prot ID:
IPI00029446
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008138
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
F
G
P
H
P
R
G
S
G
E
G
Q
G
Q
I
Site 2
T102
T
T
R
V
E
D
A
T
E
R
E
E
E
G
D
Site 3
T114
E
G
D
E
G
G
Q
T
H
L
S
P
T
A
P
Site 4
S117
E
G
G
Q
T
H
L
S
P
T
A
P
A
P
S
Site 5
T142
L
V
S
R
L
D
H
T
E
V
F
R
N
S
L
Site 6
Y153
R
N
S
L
G
L
I
Y
A
I
H
V
E
G
L
Site 7
S187
G
G
S
Q
R
T
I
S
L
G
A
G
D
R
Q
Site 8
T198
G
D
R
Q
V
I
Q
T
P
L
A
D
S
L
P
Site 9
S203
I
Q
T
P
L
A
D
S
L
P
V
S
R
C
S
Site 10
S240
E
H
K
V
L
F
L
S
R
S
Y
Q
R
L
A
Site 11
S242
K
V
L
F
L
S
R
S
Y
Q
R
L
A
D
A
Site 12
S329
P
L
P
E
P
L
Q
S
Q
T
H
S
V
L
S
Site 13
T331
P
E
P
L
Q
S
Q
T
H
S
V
L
S
M
V
Site 14
T354
D
L
A
F
P
P
P
T
T
S
T
S
S
L
K
Site 15
T355
L
A
F
P
P
P
T
T
S
T
S
S
L
K
M
Site 16
S356
A
F
P
P
P
T
T
S
T
S
S
L
K
M
Q
Site 17
S358
P
P
P
T
T
S
T
S
S
L
K
M
Q
D
K
Site 18
T439
R
G
V
P
Y
R
P
T
D
L
F
D
E
L
V
Site 19
Y475
Q
E
L
A
E
Q
L
Y
K
N
E
N
P
Y
P
Site 20
Y481
L
Y
K
N
E
N
P
Y
P
A
V
A
M
H
K
Site 21
S496
V
Q
R
P
G
E
S
S
H
L
R
R
V
P
R
Site 22
T512
F
P
R
L
D
E
G
T
V
Q
W
I
V
D
Q
Site 23
T537
A
V
K
A
E
R
R
T
T
V
P
S
G
P
P
Site 24
T538
V
K
A
E
R
R
T
T
V
P
S
G
P
P
M
Site 25
S541
E
R
R
T
T
V
P
S
G
P
P
M
T
A
I
Site 26
T546
V
P
S
G
P
P
M
T
A
I
L
E
R
C
S
Site 27
T663
R
K
L
S
P
G
V
T
Q
F
A
Y
S
C
V
Site 28
Y667
P
G
V
T
Q
F
A
Y
S
C
V
Q
E
H
V
Site 29
Y698
Q
T
H
I
R
A
L
Y
L
E
P
T
E
D
L
Site 30
T702
R
A
L
Y
L
E
P
T
E
D
L
A
P
A
Q
Site 31
S722
P
S
Q
E
D
E
R
S
A
L
D
V
A
S
E
Site 32
S728
R
S
A
L
D
V
A
S
E
Q
R
R
L
W
P
Site 33
T736
E
Q
R
R
L
W
P
T
L
S
R
E
K
Q
Q
Site 34
S738
R
R
L
W
P
T
L
S
R
E
K
Q
Q
E
L
Site 35
S751
E
L
V
Q
K
E
E
S
T
V
F
S
Q
A
I
Site 36
S755
K
E
E
S
T
V
F
S
Q
A
I
H
Y
A
N
Site 37
Y760
V
F
S
Q
A
I
H
Y
A
N
R
M
S
Y
L
Site 38
Y766
H
Y
A
N
R
M
S
Y
L
L
L
P
L
D
S
Site 39
S773
Y
L
L
L
P
L
D
S
S
K
S
R
L
L
R
Site 40
S774
L
L
L
P
L
D
S
S
K
S
R
L
L
R
E
Site 41
S776
L
P
L
D
S
S
K
S
R
L
L
R
E
R
A
Site 42
S792
L
G
D
L
E
S
A
S
N
S
L
V
T
N
S
Site 43
S794
D
L
E
S
A
S
N
S
L
V
T
N
S
M
A
Site 44
S799
S
N
S
L
V
T
N
S
M
A
G
S
V
A
E
Site 45
S803
V
T
N
S
M
A
G
S
V
A
E
S
Y
D
T
Site 46
S807
M
A
G
S
V
A
E
S
Y
D
T
E
S
G
F
Site 47
Y808
A
G
S
V
A
E
S
Y
D
T
E
S
G
F
E
Site 48
T810
S
V
A
E
S
Y
D
T
E
S
G
F
E
D
A
Site 49
T839
R
F
V
D
K
V
C
T
E
S
G
V
T
S
D
Site 50
S841
V
D
K
V
C
T
E
S
G
V
T
S
D
H
L
Site 51
S845
C
T
E
S
G
V
T
S
D
H
L
K
G
L
H
Site 52
S873
L
E
A
V
Q
R
E
S
R
R
L
P
P
I
Q
Site 53
Y903
V
L
D
G
L
R
V
Y
L
L
P
D
G
R
E
Site 54
S968
L
T
K
E
K
R
I
S
V
Q
T
P
V
D
Q
Site 55
T971
E
K
R
I
S
V
Q
T
P
V
D
Q
L
L
Q
Site 56
S985
Q
D
G
L
Q
L
R
S
C
T
F
Q
L
L
K
Site 57
S1001
A
F
D
E
E
V
G
S
D
S
A
E
L
F
R
Site 58
S1003
D
E
E
V
G
S
D
S
A
E
L
F
R
K
Q
Site 59
Y1016
K
Q
L
H
K
L
R
Y
P
P
D
I
R
A
T
Site 60
S1030
T
F
A
F
T
L
G
S
A
H
T
P
G
R
P
Site 61
T1033
F
T
L
G
S
A
H
T
P
G
R
P
P
R
V
Site 62
T1041
P
G
R
P
P
R
V
T
K
D
K
G
P
S
L
Site 63
S1047
V
T
K
D
K
G
P
S
L
R
T
L
S
R
N
Site 64
T1050
D
K
G
P
S
L
R
T
L
S
R
N
L
V
K
Site 65
S1052
G
P
S
L
R
T
L
S
R
N
L
V
K
N
A
Site 66
Y1073
Q
H
V
T
R
K
K
Y
N
P
P
S
W
E
H
Site 67
S1077
R
K
K
Y
N
P
P
S
W
E
H
R
G
Q
P
Site 68
S1094
E
D
Q
E
D
E
I
S
V
S
E
E
L
E
P
Site 69
S1096
Q
E
D
E
I
S
V
S
E
E
L
E
P
S
T
Site 70
S1102
V
S
E
E
L
E
P
S
T
L
T
P
S
S
A
Site 71
T1103
S
E
E
L
E
P
S
T
L
T
P
S
S
A
L
Site 72
T1105
E
L
E
P
S
T
L
T
P
S
S
A
L
K
P
Site 73
S1107
E
P
S
T
L
T
P
S
S
A
L
K
P
S
D
Site 74
S1108
P
S
T
L
T
P
S
S
A
L
K
P
S
D
R
Site 75
S1113
P
S
S
A
L
K
P
S
D
R
M
T
M
S
S
Site 76
T1117
L
K
P
S
D
R
M
T
M
S
S
L
V
E
R
Site 77
S1119
P
S
D
R
M
T
M
S
S
L
V
E
R
A
C
Site 78
S1120
S
D
R
M
T
M
S
S
L
V
E
R
A
C
C
Site 79
Y1130
E
R
A
C
C
R
D
Y
Q
R
L
G
L
G
T
Site 80
T1137
Y
Q
R
L
G
L
G
T
L
S
S
S
L
S
R
Site 81
S1139
R
L
G
L
G
T
L
S
S
S
L
S
R
A
K
Site 82
S1140
L
G
L
G
T
L
S
S
S
L
S
R
A
K
S
Site 83
S1141
G
L
G
T
L
S
S
S
L
S
R
A
K
S
E
Site 84
S1143
G
T
L
S
S
S
L
S
R
A
K
S
E
P
F
Site 85
S1147
S
S
L
S
R
A
K
S
E
P
F
R
I
S
P
Site 86
S1153
K
S
E
P
F
R
I
S
P
V
N
R
M
Y
A
Site 87
Y1159
I
S
P
V
N
R
M
Y
A
I
C
R
S
Y
P
Site 88
S1184
D
N
A
L
Q
R
V
S
R
C
Y
R
Q
N
R
Site 89
Y1187
L
Q
R
V
S
R
C
Y
R
Q
N
R
F
P
V
Site 90
S1202
V
C
W
R
S
G
R
S
K
A
V
L
L
R
S
Site 91
S1209
S
K
A
V
L
L
R
S
G
G
L
H
G
K
G
Site 92
S1228
F
K
A
Q
N
A
P
S
P
G
Q
S
Q
A
D
Site 93
S1232
N
A
P
S
P
G
Q
S
Q
A
D
S
S
S
L
Site 94
S1236
P
G
Q
S
Q
A
D
S
S
S
L
E
Q
E
K
Site 95
S1237
G
Q
S
Q
A
D
S
S
S
L
E
Q
E
K
Y
Site 96
S1238
Q
S
Q
A
D
S
S
S
L
E
Q
E
K
Y
L
Site 97
Y1244
S
S
L
E
Q
E
K
Y
L
Q
A
V
V
S
S
Site 98
S1250
K
Y
L
Q
A
V
V
S
S
M
P
R
Y
A
D
Site 99
Y1255
V
V
S
S
M
P
R
Y
A
D
A
S
G
R
N
Site 100
S1259
M
P
R
Y
A
D
A
S
G
R
N
T
L
S
G
Site 101
T1263
A
D
A
S
G
R
N
T
L
S
G
F
S
S
A
Site 102
S1265
A
S
G
R
N
T
L
S
G
F
S
S
A
H
M
Site 103
S1269
N
T
L
S
G
F
S
S
A
H
M
G
S
H
G
Site 104
S1274
F
S
S
A
H
M
G
S
H
G
K
W
G
S
V
Site 105
S1280
G
S
H
G
K
W
G
S
V
R
T
S
G
R
S
Site 106
T1283
G
K
W
G
S
V
R
T
S
G
R
S
S
G
L
Site 107
S1284
K
W
G
S
V
R
T
S
G
R
S
S
G
L
G
Site 108
S1287
S
V
R
T
S
G
R
S
S
G
L
G
T
D
V
Site 109
S1288
V
R
T
S
G
R
S
S
G
L
G
T
D
V
G
Site 110
T1292
G
R
S
S
G
L
G
T
D
V
G
S
R
L
A
Site 111
S1296
G
L
G
T
D
V
G
S
R
L
A
G
R
D
A
Site 112
Y1327
R
P
Q
R
A
A
L
Y
I
L
G
D
K
A
Q
Site 113
S1340
A
Q
L
K
G
V
R
S
D
P
L
Q
Q
W
E
Site 114
S1362
E
A
R
Q
V
K
A
S
F
K
K
L
L
K
A
Site 115
S1380
G
C
P
A
A
E
P
S
P
A
S
F
L
R
S
Site 116
S1383
A
A
E
P
S
P
A
S
F
L
R
S
L
E
D
Site 117
S1387
S
P
A
S
F
L
R
S
L
E
D
S
E
W
L
Site 118
S1391
F
L
R
S
L
E
D
S
E
W
L
I
Q
I
H
Site 119
T1429
E
D
G
W
D
I
T
T
Q
V
V
S
L
V
Q
Site 120
Y1443
Q
L
L
S
D
P
F
Y
R
T
L
E
G
F
R
Site 121
T1445
L
S
D
P
F
Y
R
T
L
E
G
F
R
L
L
Site 122
S1459
L
V
E
K
E
W
L
S
F
G
H
R
F
S
H
Site 123
S1465
L
S
F
G
H
R
F
S
H
R
G
A
H
T
L
Site 124
T1471
F
S
H
R
G
A
H
T
L
A
G
Q
S
S
G
Site 125
Y1507
E
F
E
F
S
Q
F
Y
L
K
F
L
G
Y
H
Site 126
Y1513
F
Y
L
K
F
L
G
Y
H
H
V
S
R
R
F
Site 127
T1522
H
V
S
R
R
F
R
T
F
L
L
D
S
D
Y
Site 128
S1527
F
R
T
F
L
L
D
S
D
Y
E
R
I
E
L
Site 129
Y1529
T
F
L
L
D
S
D
Y
E
R
I
E
L
G
L
Site 130
Y1538
R
I
E
L
G
L
L
Y
E
E
K
G
E
R
R
Site 131
Y1556
P
C
R
S
V
W
E
Y
V
D
R
L
S
K
R
Site 132
T1564
V
D
R
L
S
K
R
T
P
V
F
H
N
Y
M
Site 133
Y1570
R
T
P
V
F
H
N
Y
M
Y
A
P
E
D
A
Site 134
Y1583
D
A
E
V
L
R
P
Y
S
N
V
S
N
L
K
Site 135
S1584
A
E
V
L
R
P
Y
S
N
V
S
N
L
K
V
Site 136
Y1595
N
L
K
V
W
D
F
Y
T
E
E
T
L
A
E
Site 137
T1596
L
K
V
W
D
F
Y
T
E
E
T
L
A
E
G
Site 138
Y1606
T
L
A
E
G
P
P
Y
D
W
E
L
A
Q
G
Site 139
S1623
E
P
P
E
E
E
R
S
D
G
G
A
P
Q
S
Site 140
S1630
S
D
G
G
A
P
Q
S
R
R
R
V
V
W
P
Site 141
Y1639
R
R
V
V
W
P
C
Y
D
S
C
P
R
A
Q
Site 142
T1662
E
E
L
Q
R
L
E
T
E
L
G
Q
P
A
E
Site 143
T1674
P
A
E
R
W
K
D
T
W
D
R
V
K
A
A
Site 144
T1693
G
R
P
D
G
R
G
T
P
S
S
L
L
V
S
Site 145
S1695
P
D
G
R
G
T
P
S
S
L
L
V
S
T
A
Site 146
S1696
D
G
R
G
T
P
S
S
L
L
V
S
T
A
P
Site 147
S1700
T
P
S
S
L
L
V
S
T
A
P
H
H
R
R
Site 148
S1708
T
A
P
H
H
R
R
S
L
G
V
Y
L
Q
E
Site 149
Y1712
H
R
R
S
L
G
V
Y
L
Q
E
G
P
V
G
Site 150
T1721
Q
E
G
P
V
G
S
T
L
S
L
S
L
D
S
Site 151
S1723
G
P
V
G
S
T
L
S
L
S
L
D
S
D
Q
Site 152
S1725
V
G
S
T
L
S
L
S
L
D
S
D
Q
S
S
Site 153
S1728
T
L
S
L
S
L
D
S
D
Q
S
S
G
S
T
Site 154
S1731
L
S
L
D
S
D
Q
S
S
G
S
T
T
S
G
Site 155
S1732
S
L
D
S
D
Q
S
S
G
S
T
T
S
G
S
Site 156
S1734
D
S
D
Q
S
S
G
S
T
T
S
G
S
R
Q
Site 157
T1735
S
D
Q
S
S
G
S
T
T
S
G
S
R
Q
A
Site 158
T1736
D
Q
S
S
G
S
T
T
S
G
S
R
Q
A
A
Site 159
S1737
Q
S
S
G
S
T
T
S
G
S
R
Q
A
A
R
Site 160
S1739
S
G
S
T
T
S
G
S
R
Q
A
A
R
R
S
Site 161
S1746
S
R
Q
A
A
R
R
S
T
S
T
L
Y
S
Q
Site 162
T1747
R
Q
A
A
R
R
S
T
S
T
L
Y
S
Q
F
Site 163
S1748
Q
A
A
R
R
S
T
S
T
L
Y
S
Q
F
Q
Site 164
T1749
A
A
R
R
S
T
S
T
L
Y
S
Q
F
Q
T
Site 165
Y1751
R
R
S
T
S
T
L
Y
S
Q
F
Q
T
A
E
Site 166
S1752
R
S
T
S
T
L
Y
S
Q
F
Q
T
A
E
S
Site 167
T1756
T
L
Y
S
Q
F
Q
T
A
E
S
E
N
R
S
Site 168
S1759
S
Q
F
Q
T
A
E
S
E
N
R
S
Y
E
G
Site 169
S1763
T
A
E
S
E
N
R
S
Y
E
G
T
L
Y
K
Site 170
Y1764
A
E
S
E
N
R
S
Y
E
G
T
L
Y
K
K
Site 171
T1767
E
N
R
S
Y
E
G
T
L
Y
K
K
G
A
F
Site 172
Y1769
R
S
Y
E
G
T
L
Y
K
K
G
A
F
M
K
Site 173
Y1795
T
K
H
Q
L
R
Y
Y
D
H
R
V
D
T
E
Site 174
T1801
Y
Y
D
H
R
V
D
T
E
C
K
G
V
I
D
Site 175
T1819
V
E
A
V
A
P
G
T
P
T
M
G
A
P
K
Site 176
T1827
P
T
M
G
A
P
K
T
V
D
E
K
A
F
F
Site 177
T1838
K
A
F
F
D
V
K
T
T
R
R
V
Y
N
F
Site 178
Y1843
V
K
T
T
R
R
V
Y
N
F
C
A
Q
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation