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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPDEF
Full Name:
SAM pointed domain-containing Ets transcription factor
Alias:
bA375E1.3; PDEF; prostate epithelium-specific Ets transcription factor; prostate-derived Ets factor; prostate-specific Ets; PSE; SAM pointed domain containing ets transcription factor
Type:
Transcription factor; Nuclear receptor co-regulator
Mass (Da):
37518
Number AA:
335
UniProt ID:
O95238
International Prot ID:
IPI00018233
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
G
S
A
S
P
G
L
S
S
V
S
P
S
H
L
Site 2
T22
H
L
L
L
P
P
D
T
V
S
R
T
G
L
E
Site 3
S24
L
L
P
P
D
T
V
S
R
T
G
L
E
K
A
Site 4
S44
G
L
E
R
R
D
W
S
P
S
P
P
A
T
P
Site 5
S46
E
R
R
D
W
S
P
S
P
P
A
T
P
E
Q
Site 6
T50
W
S
P
S
P
P
A
T
P
E
Q
G
L
S
A
Site 7
Y67
L
S
Y
F
D
M
L
Y
P
E
D
S
S
W
A
Site 8
S71
D
M
L
Y
P
E
D
S
S
W
A
A
K
A
P
Site 9
S81
A
A
K
A
P
G
A
S
S
R
E
E
P
P
E
Site 10
S98
E
Q
C
P
V
I
D
S
Q
A
P
A
G
S
L
Site 11
S104
D
S
Q
A
P
A
G
S
L
D
L
V
P
G
G
Site 12
S118
G
L
T
L
E
E
H
S
L
E
Q
V
Q
S
M
Site 13
S124
H
S
L
E
Q
V
Q
S
M
V
V
G
E
V
L
Site 14
Y166
L
L
W
T
E
H
Q
Y
R
L
P
P
M
G
K
Site 15
S187
G
K
E
L
C
A
M
S
E
E
Q
F
R
Q
R
Site 16
S195
E
E
Q
F
R
Q
R
S
P
L
G
G
D
V
L
Site 17
Y226
T
S
P
G
A
I
H
Y
C
A
S
T
S
E
E
Site 18
S229
G
A
I
H
Y
C
A
S
T
S
E
E
S
W
T
Site 19
T230
A
I
H
Y
C
A
S
T
S
E
E
S
W
T
D
Site 20
S231
I
H
Y
C
A
S
T
S
E
E
S
W
T
D
S
Site 21
S234
C
A
S
T
S
E
E
S
W
T
D
S
E
V
D
Site 22
T236
S
T
S
E
E
S
W
T
D
S
E
V
D
S
S
Site 23
S238
S
E
E
S
W
T
D
S
E
V
D
S
S
C
S
Site 24
S242
W
T
D
S
E
V
D
S
S
C
S
G
Q
P
I
Site 25
S243
T
D
S
E
V
D
S
S
C
S
G
Q
P
I
H
Site 26
S245
S
E
V
D
S
S
C
S
G
Q
P
I
H
L
W
Site 27
S264
E
L
L
L
K
P
H
S
Y
G
R
F
I
R
W
Site 28
Y302
K
N
R
P
A
M
N
Y
D
K
L
S
R
S
I
Site 29
S308
N
Y
D
K
L
S
R
S
I
R
Q
Y
Y
K
K
Site 30
Y312
L
S
R
S
I
R
Q
Y
Y
K
K
G
I
I
R
Site 31
Y313
S
R
S
I
R
Q
Y
Y
K
K
G
I
I
R
K
Site 32
S324
I
I
R
K
P
D
I
S
Q
R
L
V
Y
Q
F
Site 33
Y329
D
I
S
Q
R
L
V
Y
Q
F
V
H
P
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation