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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LETM1
Full Name:
LETM1 and EF-hand domain-containing protein 1, mitochondrial
Alias:
Leucine zipper-EF-hand-containing transmembrane protein 1
Type:
Mass (Da):
83336
Number AA:
739
UniProt ID:
O95202
International Prot ID:
IPI00017592
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005743
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005509
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
I
L
L
R
S
C
R
Site 2
S8
M
A
S
I
L
L
R
S
C
R
G
R
A
P
A
Site 3
Y23
R
L
P
P
P
P
R
Y
T
V
P
R
G
S
P
Site 4
T24
L
P
P
P
P
R
Y
T
V
P
R
G
S
P
G
Site 5
S29
R
Y
T
V
P
R
G
S
P
G
D
P
A
H
L
Site 6
S37
P
G
D
P
A
H
L
S
C
A
S
T
L
G
L
Site 7
Y62
C
T
P
I
H
P
V
Y
T
S
S
R
G
D
H
Site 8
S64
P
I
H
P
V
Y
T
S
S
R
G
D
H
L
G
Site 9
S84
P
E
C
L
R
I
V
S
R
A
P
W
T
S
T
Site 10
S110
L
P
V
R
G
W
H
S
S
R
P
V
R
D
D
Site 11
S111
P
V
R
G
W
H
S
S
R
P
V
R
D
D
S
Site 12
S118
S
R
P
V
R
D
D
S
V
V
E
K
S
L
K
Site 13
S123
D
D
S
V
V
E
K
S
L
K
S
L
K
D
K
Site 14
S126
V
V
E
K
S
L
K
S
L
K
D
K
N
K
K
Site 15
Y141
L
E
E
G
G
P
V
Y
S
P
P
A
E
V
V
Site 16
S142
E
E
G
G
P
V
Y
S
P
P
A
E
V
V
V
Site 17
Y164
V
L
D
E
L
K
H
Y
Y
H
G
F
R
L
L
Site 18
Y165
L
D
E
L
K
H
Y
Y
H
G
F
R
L
L
W
Site 19
T175
F
R
L
L
W
I
D
T
K
I
A
A
R
M
L
Site 20
S190
W
R
I
L
N
G
H
S
L
T
R
R
E
R
R
Site 21
T192
I
L
N
G
H
S
L
T
R
R
E
R
R
Q
F
Site 22
T239
F
P
N
M
L
P
S
T
F
E
T
Q
S
L
K
Site 23
T242
M
L
P
S
T
F
E
T
Q
S
L
K
E
E
R
Site 24
S244
P
S
T
F
E
T
Q
S
L
K
E
E
R
L
K
Site 25
T283
K
A
A
K
G
S
A
T
K
D
F
S
V
F
F
Site 26
S287
G
S
A
T
K
D
F
S
V
F
F
Q
K
I
R
Site 27
T296
F
F
Q
K
I
R
E
T
G
E
R
P
S
N
E
Site 28
S301
R
E
T
G
E
R
P
S
N
E
E
I
M
R
F
Site 29
S309
N
E
E
I
M
R
F
S
K
L
F
E
D
E
L
Site 30
T317
K
L
F
E
D
E
L
T
L
D
N
L
T
R
P
Site 31
S337
C
K
L
L
E
L
Q
S
I
G
T
N
N
F
L
Site 32
T349
N
F
L
R
F
Q
L
T
M
R
L
R
S
I
K
Site 33
S354
Q
L
T
M
R
L
R
S
I
K
A
D
D
K
L
Site 34
S369
I
A
E
E
G
V
D
S
L
N
V
K
E
L
Q
Site 35
T390
G
M
R
A
L
G
V
T
E
D
R
L
R
G
Q
Site 36
T426
R
A
M
Y
L
P
D
T
L
S
P
A
D
Q
L
Site 37
S428
M
Y
L
P
D
T
L
S
P
A
D
Q
L
K
S
Site 38
S435
S
P
A
D
Q
L
K
S
T
L
Q
T
L
P
E
Site 39
T436
P
A
D
Q
L
K
S
T
L
Q
T
L
P
E
I
Site 40
T439
Q
L
K
S
T
L
Q
T
L
P
E
I
V
A
K
Site 41
T509
A
A
P
Q
R
P
G
T
E
P
Q
P
E
M
P
Site 42
T518
P
Q
P
E
M
P
D
T
V
L
Q
S
E
T
L
Site 43
T528
Q
S
E
T
L
K
D
T
A
P
V
L
E
G
L
Site 44
T541
G
L
K
E
E
E
I
T
K
E
E
I
D
I
L
Site 45
S549
K
E
E
I
D
I
L
S
D
A
C
S
K
L
Q
Site 46
S553
D
I
L
S
D
A
C
S
K
L
Q
E
Q
K
K
Site 47
S561
K
L
Q
E
Q
K
K
S
L
T
K
E
K
E
E
Site 48
Y579
L
K
E
D
V
Q
D
Y
S
E
D
L
Q
E
I
Site 49
S580
K
E
D
V
Q
D
Y
S
E
D
L
Q
E
I
K
Site 50
S591
Q
E
I
K
K
E
L
S
K
T
G
E
E
K
Y
Site 51
T593
I
K
K
E
L
S
K
T
G
E
E
K
Y
V
E
Site 52
Y598
S
K
T
G
E
E
K
Y
V
E
E
S
K
A
S
Site 53
S605
Y
V
E
E
S
K
A
S
K
R
L
T
K
R
V
Site 54
T609
S
K
A
S
K
R
L
T
K
R
V
Q
Q
M
I
Site 55
S624
G
Q
I
D
G
L
I
S
Q
L
E
M
D
Q
Q
Site 56
S666
Q
V
K
H
I
P
E
S
K
L
T
S
L
A
A
Site 57
S703
D
K
E
D
V
H
I
S
T
S
Q
V
A
E
I
Site 58
T713
Q
V
A
E
I
V
A
T
L
E
K
E
E
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation