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Updated November 2019
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Protein Info
Short Name:
BZRAP1
Full Name:
Peripheral-type benzodiazepine receptor-associated protein 1
Alias:
Benzodiazapine receptor (peripheral) associated protein 1; KIAA0612; PBR-IP; Peripheral benzodiazepine receptor-interacting; Peripheral benzodiazepine receptor-interacting protein; Peripheral-type benzodiazepine receptor-associated 1; PRAX-1; RBP1; RIMB1; RIM-binding 1; RIMBP1; RIM-BP1; RIMS-binding protein 1
Type:
Adaptor/scaffold
Mass (Da):
200033
Number AA:
1857
UniProt ID:
O95153
International Prot ID:
IPI00006254
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0030156
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
Q
L
T
T
L
P
R
P
G
D
P
Site 2
T28
L
P
T
W
H
S
W
T
P
G
R
G
G
E
P
Site 3
S36
P
G
R
G
G
E
P
S
S
A
A
P
S
I
A
Site 4
S37
G
R
G
G
E
P
S
S
A
A
P
S
I
A
D
Site 5
S41
E
P
S
S
A
A
P
S
I
A
D
T
P
P
A
Site 6
S57
L
Q
L
Q
E
L
R
S
E
E
S
S
K
P
K
Site 7
S60
Q
E
L
R
S
E
E
S
S
K
P
K
G
D
G
Site 8
S61
E
L
R
S
E
E
S
S
K
P
K
G
D
G
S
Site 9
S68
S
K
P
K
G
D
G
S
S
R
P
V
G
G
T
Site 10
S69
K
P
K
G
D
G
S
S
R
P
V
G
G
T
D
Site 11
T75
S
S
R
P
V
G
G
T
D
P
E
G
A
E
A
Site 12
S86
G
A
E
A
C
L
P
S
L
G
Q
Q
A
S
S
Site 13
S92
P
S
L
G
Q
Q
A
S
S
S
G
P
A
C
Q
Site 14
S94
L
G
Q
Q
A
S
S
S
G
P
A
C
Q
R
P
Site 15
S117
L
K
A
K
L
N
M
S
F
G
D
R
P
N
L
Site 16
S150
E
N
Q
M
L
R
K
S
S
F
P
E
T
E
E
Site 17
S151
N
Q
M
L
R
K
S
S
F
P
E
T
E
E
K
Site 18
T155
R
K
S
S
F
P
E
T
E
E
K
V
R
R
L
Site 19
T186
R
A
R
K
L
Q
E
T
N
L
R
V
V
S
A
Site 20
S192
E
T
N
L
R
V
V
S
A
P
L
P
R
P
G
Site 21
T200
A
P
L
P
R
P
G
T
S
L
E
L
C
R
K
Site 22
S201
P
L
P
R
P
G
T
S
L
E
L
C
R
K
A
Site 23
S218
R
Q
R
A
R
D
L
S
E
T
A
S
A
L
L
Site 24
T220
R
A
R
D
L
S
E
T
A
S
A
L
L
A
K
Site 25
S222
R
D
L
S
E
T
A
S
A
L
L
A
K
D
K
Site 26
T246
R
E
L
Q
A
R
L
T
L
V
G
K
E
G
P
Site 27
S268
F
D
R
L
L
R
E
S
Q
R
E
V
L
R
L
Site 28
T287
A
L
R
N
Q
R
E
T
L
P
L
P
P
S
W
Site 29
S293
E
T
L
P
L
P
P
S
W
P
P
G
P
A
L
Site 30
T316
P
G
A
P
G
E
A
T
P
Q
E
D
A
D
N
Site 31
S345
Q
Q
L
E
S
E
L
S
K
K
R
K
K
C
E
Site 32
S353
K
K
R
K
K
C
E
S
L
E
Q
E
A
R
K
Site 33
S390
V
E
E
N
S
R
L
S
G
R
A
T
E
K
E
Site 34
T394
S
R
L
S
G
R
A
T
E
K
E
Q
V
E
W
Site 35
T414
R
G
Q
L
L
G
V
T
Q
E
R
D
S
A
L
Site 36
S419
G
V
T
Q
E
R
D
S
A
L
R
K
S
Q
G
Site 37
S424
R
D
S
A
L
R
K
S
Q
G
L
Q
S
K
L
Site 38
S429
R
K
S
Q
G
L
Q
S
K
L
E
S
L
E
Q
Site 39
S433
G
L
Q
S
K
L
E
S
L
E
Q
V
L
K
H
Site 40
S461
E
H
E
Q
A
R
L
S
L
R
E
K
Q
E
E
Site 41
S496
L
L
E
S
T
L
D
S
M
Q
A
R
V
R
E
Site 42
S510
E
L
E
E
Q
C
R
S
Q
T
E
Q
F
S
L
Site 43
T512
E
E
Q
C
R
S
Q
T
E
Q
F
S
L
L
A
Site 44
S516
R
S
Q
T
E
Q
F
S
L
L
A
Q
E
L
Q
Site 45
S543
T
S
A
L
D
C
G
S
L
G
D
C
P
P
P
Site 46
S563
I
P
Q
P
C
R
G
S
G
P
K
D
L
D
L
Site 47
S574
D
L
D
L
P
P
G
S
P
G
R
C
T
P
K
Site 48
T579
P
G
S
P
G
R
C
T
P
K
S
S
E
P
A
Site 49
S582
P
G
R
C
T
P
K
S
S
E
P
A
P
A
T
Site 50
S583
G
R
C
T
P
K
S
S
E
P
A
P
A
T
L
Site 51
T589
S
S
E
P
A
P
A
T
L
T
G
V
P
R
R
Site 52
T591
E
P
A
P
A
T
L
T
G
V
P
R
R
T
A
Site 53
T597
L
T
G
V
P
R
R
T
A
K
K
A
E
S
L
Site 54
S603
R
T
A
K
K
A
E
S
L
S
N
S
S
H
S
Site 55
S605
A
K
K
A
E
S
L
S
N
S
S
H
S
E
S
Site 56
S607
K
A
E
S
L
S
N
S
S
H
S
E
S
I
H
Site 57
S608
A
E
S
L
S
N
S
S
H
S
E
S
I
H
N
Site 58
S610
S
L
S
N
S
S
H
S
E
S
I
H
N
S
P
Site 59
S612
S
N
S
S
H
S
E
S
I
H
N
S
P
K
S
Site 60
S616
H
S
E
S
I
H
N
S
P
K
S
C
P
T
P
Site 61
S619
S
I
H
N
S
P
K
S
C
P
T
P
E
V
D
Site 62
T622
N
S
P
K
S
C
P
T
P
E
V
D
T
A
S
Site 63
S629
T
P
E
V
D
T
A
S
E
V
E
E
L
E
A
Site 64
S663
Q
V
F
L
A
R
Y
S
Y
N
P
F
E
G
P
Site 65
Y664
V
F
L
A
R
Y
S
Y
N
P
F
E
G
P
N
Site 66
Y689
A
G
E
Y
I
Y
I
Y
G
N
M
D
E
D
G
Site 67
S712
G
R
R
G
L
V
P
S
N
F
V
E
R
V
S
Site 68
S719
S
N
F
V
E
R
V
S
D
D
D
L
L
T
S
Site 69
T725
V
S
D
D
D
L
L
T
S
L
P
P
E
L
A
Site 70
S726
S
D
D
D
L
L
T
S
L
P
P
E
L
A
D
Site 71
S735
P
P
E
L
A
D
L
S
H
S
S
G
P
E
L
Site 72
S737
E
L
A
D
L
S
H
S
S
G
P
E
L
S
F
Site 73
S743
H
S
S
G
P
E
L
S
F
L
S
V
G
G
G
Site 74
S752
L
S
V
G
G
G
G
S
S
S
G
G
Q
S
S
Site 75
S753
S
V
G
G
G
G
S
S
S
G
G
Q
S
S
V
Site 76
S754
V
G
G
G
G
S
S
S
G
G
Q
S
S
V
G
Site 77
S758
G
S
S
S
G
G
Q
S
S
V
G
R
S
Q
P
Site 78
S759
S
S
S
G
G
Q
S
S
V
G
R
S
Q
P
R
Site 79
S763
G
Q
S
S
V
G
R
S
Q
P
R
P
E
E
E
Site 80
S777
E
D
A
G
D
E
L
S
L
S
P
S
P
E
G
Site 81
S779
A
G
D
E
L
S
L
S
P
S
P
E
G
L
G
Site 82
S781
D
E
L
S
L
S
P
S
P
E
G
L
G
E
P
Site 83
T863
H
I
S
V
Q
A
L
T
S
R
G
S
S
D
P
Site 84
S864
I
S
V
Q
A
L
T
S
R
G
S
S
D
P
L
Site 85
S867
Q
A
L
T
S
R
G
S
S
D
P
L
R
C
C
Site 86
S868
A
L
T
S
R
G
S
S
D
P
L
R
C
C
L
Site 87
S886
A
R
A
G
V
V
P
S
Q
L
R
V
H
R
L
Site 88
T894
Q
L
R
V
H
R
L
T
A
T
S
A
E
I
T
Site 89
T901
T
A
T
S
A
E
I
T
W
V
P
G
N
S
N
Site 90
Y914
S
N
L
A
H
A
I
Y
L
N
G
E
E
C
P
Site 91
S924
G
E
E
C
P
P
A
S
P
S
T
Y
W
A
T
Site 92
Y928
P
P
A
S
P
S
T
Y
W
A
T
F
C
H
L
Site 93
T939
F
C
H
L
R
P
G
T
P
Y
Q
A
Q
V
E
Site 94
Y941
H
L
R
P
G
T
P
Y
Q
A
Q
V
E
A
Q
Site 95
T968
R
L
E
Q
R
A
A
T
L
Q
F
T
T
L
P
Site 96
T972
R
A
A
T
L
Q
F
T
T
L
P
A
G
P
P
Site 97
T1017
T
S
N
G
V
R
V
T
G
Y
A
I
Y
A
D
Site 98
Y1019
N
G
V
R
V
T
G
Y
A
I
Y
A
D
G
Q
Site 99
T1059
C
R
E
V
V
V
R
T
M
S
P
H
G
E
S
Site 100
S1061
E
V
V
V
R
T
M
S
P
H
G
E
S
A
D
Site 101
S1066
T
M
S
P
H
G
E
S
A
D
S
I
P
A
P
Site 102
S1069
P
H
G
E
S
A
D
S
I
P
A
P
I
T
P
Site 103
S1088
A
S
L
P
A
R
V
S
C
P
S
P
H
P
S
Site 104
S1091
P
A
R
V
S
C
P
S
P
H
P
S
P
E
A
Site 105
S1095
S
C
P
S
P
H
P
S
P
E
A
R
A
P
L
Site 106
S1104
E
A
R
A
P
L
A
S
A
S
P
G
P
G
D
Site 107
S1106
R
A
P
L
A
S
A
S
P
G
P
G
D
P
S
Site 108
S1113
S
P
G
P
G
D
P
S
S
P
L
Q
H
P
A
Site 109
S1114
P
G
P
G
D
P
S
S
P
L
Q
H
P
A
P
Site 110
T1124
Q
H
P
A
P
L
G
T
Q
E
P
P
G
A
P
Site 111
S1134
P
P
G
A
P
P
A
S
P
S
R
E
M
A
K
Site 112
S1136
G
A
P
P
A
S
P
S
R
E
M
A
K
G
S
Site 113
S1143
S
R
E
M
A
K
G
S
H
E
D
P
P
A
P
Site 114
S1152
E
D
P
P
A
P
C
S
Q
E
E
A
G
A
A
Site 115
T1168
L
G
T
S
E
E
R
T
A
S
T
S
T
L
G
Site 116
S1170
T
S
E
E
R
T
A
S
T
S
T
L
G
E
K
Site 117
S1172
E
E
R
T
A
S
T
S
T
L
G
E
K
D
P
Site 118
S1185
D
P
G
P
A
A
P
S
L
A
K
Q
E
A
E
Site 119
S1202
A
G
E
A
C
P
A
S
S
S
T
Q
G
A
R
Site 120
S1204
E
A
C
P
A
S
S
S
T
Q
G
A
R
A
Q
Site 121
T1216
R
A
Q
Q
A
P
N
T
E
M
C
Q
G
G
D
Site 122
S1226
C
Q
G
G
D
P
G
S
G
L
R
P
R
A
E
Site 123
T1237
P
R
A
E
K
E
D
T
A
E
L
G
V
H
L
Site 124
S1247
L
G
V
H
L
V
N
S
L
V
D
H
G
R
N
Site 125
S1255
L
V
D
H
G
R
N
S
D
L
S
D
I
Q
E
Site 126
S1258
H
G
R
N
S
D
L
S
D
I
Q
E
E
E
E
Site 127
S1277
E
E
E
E
E
L
G
S
R
T
C
S
F
Q
K
Site 128
T1279
E
E
E
L
G
S
R
T
C
S
F
Q
K
Q
V
Site 129
S1281
E
L
G
S
R
T
C
S
F
Q
K
Q
V
A
G
Site 130
S1290
Q
K
Q
V
A
G
N
S
I
R
E
N
G
A
K
Site 131
S1298
I
R
E
N
G
A
K
S
Q
P
D
P
F
C
E
Site 132
S1308
D
P
F
C
E
T
D
S
D
E
E
I
L
E
Q
Site 133
S1348
E
D
E
E
E
E
K
S
G
A
G
C
S
S
R
Site 134
S1353
E
K
S
G
A
G
C
S
S
R
D
P
G
P
P
Site 135
S1354
K
S
G
A
G
C
S
S
R
D
P
G
P
P
E
Site 136
S1371
L
L
G
L
G
C
D
S
G
Q
P
R
R
P
G
Site 137
S1383
R
P
G
Q
C
P
L
S
P
E
S
S
R
A
G
Site 138
S1386
Q
C
P
L
S
P
E
S
S
R
A
G
D
C
L
Site 139
S1387
C
P
L
S
P
E
S
S
R
A
G
D
C
L
E
Site 140
S1403
M
P
G
L
V
G
G
S
S
R
R
R
G
G
G
Site 141
S1404
P
G
L
V
G
G
S
S
R
R
R
G
G
G
S
Site 142
S1411
S
R
R
R
G
G
G
S
P
E
K
P
P
S
R
Site 143
S1417
G
S
P
E
K
P
P
S
R
R
R
P
P
D
P
Site 144
S1429
P
D
P
R
E
H
C
S
R
L
L
S
N
N
G
Site 145
S1433
E
H
C
S
R
L
L
S
N
N
G
P
Q
A
S
Site 146
S1440
S
N
N
G
P
Q
A
S
G
R
L
G
P
T
R
Site 147
T1460
P
V
I
E
G
P
R
T
G
L
E
A
S
G
R
Site 148
S1465
P
R
T
G
L
E
A
S
G
R
G
R
L
G
P
Site 149
S1473
G
R
G
R
L
G
P
S
R
R
C
S
R
G
R
Site 150
S1477
L
G
P
S
R
R
C
S
R
G
R
A
L
E
P
Site 151
S1498
S
P
K
C
L
E
I
S
I
E
Y
D
S
E
D
Site 152
S1503
E
I
S
I
E
Y
D
S
E
D
E
Q
E
A
G
Site 153
S1511
E
D
E
Q
E
A
G
S
G
G
I
S
I
T
S
Site 154
S1515
E
A
G
S
G
G
I
S
I
T
S
S
C
Y
P
Site 155
T1517
G
S
G
G
I
S
I
T
S
S
C
Y
P
G
D
Site 156
S1518
S
G
G
I
S
I
T
S
S
C
Y
P
G
D
G
Site 157
S1519
G
G
I
S
I
T
S
S
C
Y
P
G
D
G
E
Site 158
Y1521
I
S
I
T
S
S
C
Y
P
G
D
G
E
A
W
Site 159
T1530
G
D
G
E
A
W
G
T
A
T
V
G
R
P
R
Site 160
T1532
G
E
A
W
G
T
A
T
V
G
R
P
R
G
P
Site 161
S1544
R
G
P
P
K
A
N
S
G
P
K
P
Y
P
R
Site 162
Y1549
A
N
S
G
P
K
P
Y
P
R
L
P
A
W
E
Site 163
S1566
E
P
E
R
R
G
R
S
A
T
G
R
A
K
E
Site 164
T1568
E
R
R
G
R
S
A
T
G
R
A
K
E
P
L
Site 165
S1576
G
R
A
K
E
P
L
S
R
A
T
E
T
G
E
Site 166
T1579
K
E
P
L
S
R
A
T
E
T
G
E
A
R
G
Site 167
S1590
E
A
R
G
Q
D
G
S
G
R
R
G
P
Q
K
Site 168
S1615
A
E
L
V
P
A
R
S
P
S
E
T
L
A
Y
Site 169
S1617
L
V
P
A
R
S
P
S
E
T
L
A
Y
Q
H
Site 170
T1619
P
A
R
S
P
S
E
T
L
A
Y
Q
H
L
P
Site 171
Y1622
S
P
S
E
T
L
A
Y
Q
H
L
P
V
R
I
Site 172
S1640
L
F
D
Y
D
P
V
S
M
S
P
N
P
D
A
Site 173
S1642
D
Y
D
P
V
S
M
S
P
N
P
D
A
G
E
Site 174
Y1672
D
K
D
A
D
G
F
Y
Q
G
E
G
G
G
R
Site 175
Y1682
E
G
G
G
R
T
G
Y
I
P
C
N
M
V
A
Site 176
S1695
V
A
E
V
A
V
D
S
P
A
G
R
Q
Q
L
Site 177
Y1707
Q
Q
L
L
Q
R
G
Y
L
S
P
D
I
L
L
Site 178
Y1724
S
G
N
G
P
F
V
Y
S
T
A
H
T
T
G
Site 179
S1725
G
N
G
P
F
V
Y
S
T
A
H
T
T
G
P
Site 180
T1726
N
G
P
F
V
Y
S
T
A
H
T
T
G
P
P
Site 181
T1729
F
V
Y
S
T
A
H
T
T
G
P
P
P
K
P
Site 182
S1739
P
P
P
K
P
R
R
S
K
K
A
E
S
E
G
Site 183
S1760
G
P
P
K
L
V
P
S
A
D
L
K
A
P
H
Site 184
Y1775
S
M
V
A
A
F
D
Y
N
P
Q
E
S
S
P
Site 185
S1781
D
Y
N
P
Q
E
S
S
P
N
M
D
V
E
A
Site 186
Y1810
G
M
D
D
D
G
F
Y
Y
G
E
L
N
G
Q
Site 187
Y1811
M
D
D
D
G
F
Y
Y
G
E
L
N
G
Q
R
Site 188
S1823
G
Q
R
G
L
V
P
S
N
F
L
E
G
P
G
Site 189
T1842
G
L
D
R
E
P
R
T
P
Q
A
E
S
Q
R
Site 190
S1847
P
R
T
P
Q
A
E
S
Q
R
T
R
R
R
R
Site 191
T1850
P
Q
A
E
S
Q
R
T
R
R
R
R
V
Q
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation