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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MFN2
Full Name:
Mitofusin-2
Alias:
Transmembrane GTPase MFN2
Type:
Mass (Da):
86384
Number AA:
757
UniProt ID:
O95140
International Prot ID:
IPI00642329
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005741
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0003924
PhosphoSite+
KinaseNET
Biological Process:
GO:0006605
GO:0006626
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Mitofusin-2 pan-specific antibody AB-NN290-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN290-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
H
M
A
E
V
N
A
S
P
L
K
H
F
V
T
Site 2
T34
S
P
L
K
H
F
V
T
A
K
K
K
I
N
G
Site 3
S53
L
G
A
Y
I
Q
E
S
A
T
F
L
E
D
T
Site 4
T55
A
Y
I
Q
E
S
A
T
F
L
E
D
T
Y
R
Site 5
T60
S
A
T
F
L
E
D
T
Y
R
N
A
E
L
D
Site 6
Y61
A
T
F
L
E
D
T
Y
R
N
A
E
L
D
P
Site 7
T70
N
A
E
L
D
P
V
T
T
E
E
Q
V
L
D
Site 8
S83
L
D
V
K
G
Y
L
S
K
V
R
G
I
S
E
Site 9
S89
L
S
K
V
R
G
I
S
E
V
L
A
R
R
H
Site 10
S110
G
R
T
S
N
G
K
S
T
V
I
N
A
M
L
Site 11
T111
R
T
S
N
G
K
S
T
V
I
N
A
M
L
W
Site 12
S124
L
W
D
K
V
L
P
S
G
I
G
H
T
T
N
Site 13
S151
A
F
L
L
T
E
G
S
E
E
K
R
S
A
K
Site 14
S156
E
G
S
E
E
K
R
S
A
K
T
V
N
Q
L
Site 15
T159
E
E
K
R
S
A
K
T
V
N
Q
L
A
H
A
Site 16
S177
D
K
Q
L
H
A
G
S
L
V
S
V
M
W
P
Site 17
S186
V
S
V
M
W
P
N
S
K
C
P
L
L
K
D
Site 18
T206
D
S
P
G
I
D
V
T
T
E
L
D
S
W
I
Site 19
T207
S
P
G
I
D
V
T
T
E
L
D
S
W
I
D
Site 20
T236
S
E
S
T
L
M
Q
T
E
K
H
F
F
H
K
Site 21
S245
K
H
F
F
H
K
V
S
E
R
L
S
R
P
N
Site 22
S249
H
K
V
S
E
R
L
S
R
P
N
I
F
I
L
Site 23
S263
L
N
N
R
W
D
A
S
A
S
E
P
E
Y
M
Site 24
S265
N
R
W
D
A
S
A
S
E
P
E
Y
M
E
E
Site 25
Y269
A
S
A
S
E
P
E
Y
M
E
E
V
R
R
Q
Site 26
T282
R
Q
H
M
E
R
C
T
S
F
L
V
D
E
L
Site 27
S283
Q
H
M
E
R
C
T
S
F
L
V
D
E
L
G
Site 28
S295
E
L
G
V
V
D
R
S
Q
A
G
D
R
I
F
Site 29
S350
R
R
F
E
E
C
I
S
Q
S
A
V
K
T
K
Site 30
T356
I
S
Q
S
A
V
K
T
K
F
E
Q
H
T
V
Site 31
T362
K
T
K
F
E
Q
H
T
V
R
A
K
Q
I
A
Site 32
Y389
A
A
R
E
Q
Q
V
Y
C
E
E
M
R
E
E
Site 33
Y415
L
E
L
L
A
Q
D
Y
K
L
R
I
K
Q
I
Site 34
T423
K
L
R
I
K
Q
I
T
E
E
V
E
R
Q
V
Site 35
S431
E
E
V
E
R
Q
V
S
T
A
M
A
E
E
I
Site 36
S442
A
E
E
I
R
R
L
S
V
L
V
D
D
Y
Q
Site 37
Y448
L
S
V
L
V
D
D
Y
Q
M
D
F
H
P
S
Site 38
S455
Y
Q
M
D
F
H
P
S
P
V
V
L
K
V
Y
Site 39
S479
E
G
L
G
R
N
M
S
D
R
C
S
T
A
I
Site 40
S483
R
N
M
S
D
R
C
S
T
A
I
T
N
S
L
Site 41
T484
N
M
S
D
R
C
S
T
A
I
T
N
S
L
Q
Site 42
T487
D
R
C
S
T
A
I
T
N
S
L
Q
T
M
Q
Site 43
S562
R
F
L
G
P
K
N
S
R
R
A
L
M
G
Y
Site 44
Y569
S
R
R
A
L
M
G
Y
N
D
Q
V
Q
R
P
Site 45
T580
V
Q
R
P
I
P
L
T
P
A
N
P
S
M
P
Site 46
S585
P
L
T
P
A
N
P
S
M
P
P
L
P
Q
G
Site 47
T595
P
L
P
Q
G
S
L
T
Q
E
E
F
M
V
S
Site 48
S609
S
M
V
T
G
L
A
S
L
T
S
R
T
S
M
Site 49
T651
L
Y
V
Y
E
R
L
T
W
T
T
K
A
K
E
Site 50
S678
E
K
L
Q
L
V
I
S
Y
T
G
S
N
C
S
Site 51
T680
L
Q
L
V
I
S
Y
T
G
S
N
C
S
H
Q
Site 52
S682
L
V
I
S
Y
T
G
S
N
C
S
H
Q
V
Q
Site 53
S685
S
Y
T
G
S
N
C
S
H
Q
V
Q
Q
E
L
Site 54
T695
V
Q
Q
E
L
S
G
T
F
A
H
L
C
Q
Q
Site 55
S726
K
K
I
E
V
L
D
S
L
Q
S
K
A
K
L
Site 56
S729
E
V
L
D
S
L
Q
S
K
A
K
L
L
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation